Postdoctoral Research Associate /Research Fellow
closing date August 28th 2018
We are recruiting a postdoc to lead analysis of a MRC funded study investigating genetic and environmental regulation of Chromosome X in female twins.
The project will:
- Investigate both environmental and genetic influences on skewed X-inactivation in the deeply-phenotyped TwinsUK cohort, including the longitudinal relationship between skewed X-inactivation and whole-genome sequences, healthy ageing, common disease and electronic health records.
- Identify genes escaping from X-inactivation and characterize how escape varies between individuals (including identical twin pairs), across cell-types, and over time in the same individual using both existing TwinsUK multi-omic datasets and new deep RNAseq generated in this project in immune cells from targeted twins.
- Explore local and distal genetic regulation of gene expression on chromosome X (eQTLs and splice-QTLs).
The successful candidate will have either experience in analysis of transcriptomes or other omic data or a strong foundation the genetic epidemiology of complex traits.
Full details are here: