The Genetic Epidemiology of Degenerative Disc Disease


This fellowship aims to use a number of different approaches to unravel the genetic epidemiology of intervertebral disc degeneration. In particular, we use twin spine MR scans and imaging from other cohorts to meta-analyse a variable derived in each imaging system. We are also contributing spine phenotypes to other consortia. In our own data we will also examine the regions under existing linkage peaks and candidate genes to further the understanding of the genetic variants involved in this common cause of low back pain.


The Wellcome Trust