2006

De Lange M, Andrew T, Snieder H, Ge D, Futers TS, Standeven K, Spector TD, Grant PJ, Ariens RAS. Joint linkage and association of 6 single nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus . Arterioscler Thromb Vasc Biol 2006 Aug; 26 (8):1914-9

Reavley CM, Golding JF, Cherkas LF, Spector TD, MacGregor AJ. Genetic influences on motion sickness susceptibility in adult women: a classical twin study. Aviat Space Environ Med 2006 Nov; 77 (11): 1148-52

Spector TD, Williams FM.The UK Adult Twin Registry (TwinsUK). Twin Reserch and Human Genetics 2006; 9 (6): 899-906 

Majava M, Bishop PN, Hagg P, Scott PG, Rice A, Inglehearn C, Hammond CJ, Spector TD, Ala -Kokko L, Mannikko M. Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopia . Hum Mutat 2006 Nov 20; 28 (4):336-344

Harding B, Curley AJ, Hannan FM, Christie PT, Bowl MR, Turner JJO, Barber M, Gillham-Nasenya I, Hampson G, Spector TD, Thakker RV. Functional characterization of calcium sensing receptor polymorphisms and absence of association with indices of calcium homeostasis and bone mineral density. Clinical Endocrinology 2006;65:598-605 

Williams FMK, Spector TD. Osteoarthritis. Medicine 2006; 34 (9): 364-368 

Falchi M, Spector TD, Perks U, Kato BS, Bataille V. Genome-wide search for nevus density shows linkage to two melanoma loci on chromosome 9 and identifies a new QTL on 5q31 in an adult twin cohort. Human Molecular Genetics 2006; 15 (20):2975-9 

Zhai G, Aviv A, Hunter DJ, Hart DJ, Gardner JP, Kimura M, Lu X, Valdes AM, Spector TD. Reduction of leukocyte telomere length in radiographic hand osteoarthritis: a population based study. Ann Rheum Disease 2006; 65 (11):1444-1448 

Skidmore PML, Cassidy A, Swaminathan R, Falchi M, Spector TD, MacGregor AJ. Intrauterine, environmental, and genetic influences in the relationship between birth weight and lipids in a female twin cohort. Arterioscler. Thromb. Vasc. Biol 2006; 26(10):2373-9 

Camplejohn RS, Hodgson S, Carter N, Kao BS, Spector TD. Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins. British Journal of Cancer 2006; 95:520-524.

Aviv A, Valdes A, Spector TD. Human telomere biology: pitfalls of moving from the laboratory to epidemiology. International Journal of Epidemiology 2006 Dec; 35:1424-1429 

Bingham CO, Buckland-Wright JC, Garnero P, Cohen SB, Dougados M, Adami S, Clauw DJ, Spector TD, Pelletier JP, Raynauld JP, Strand V, Simon LS, Meyer JM, Cline GA, Beary JF. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow x-ray progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee OA structural arthritis (KOSTAR) study. Arthritis & Rheumatism 2006 Nov; 54(11):3494-507 

Jamshidi Y, Snieder H, Wang X, Pavitt MJ, Spector TD, Carter ND, O’Dell SD. Phosphatidylinositol 3-kinase p85 alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population. Diabetology 2006 Nov;49 (11):2659-2667 

Spencer-Jones NJ, Ge D, Snieder H, Perks U, Swaminathan R, Spector TD, Carter ND, O’Dell SD. AMP-Kinase ALPHA2 subunit gene PRKAA2 variants are associated with total LDL and HDL-cholesterol normal females. J Med Genet 2006; 43 (12): 936-42 

Cherkas LF, Aviv A, Valdes AM, Hunkin JL, Gardner JP, Surdulescu GL, Kimura M, Spector TD. The effects of social status on biological ageing as measured by white cell telomere length. Aging Cell 2006; 5 (5): 361-365 

Prainsack B, Spector TD, Cherkas L. The cloning experience: twins and human reproductive cloning. Social Science and Medicine 2006;63:2739-2752 

Williams FM, Spector TD. Recent advances in the genetics of osteoporosis. J Musculoskelet Neuronal Interact 2006; 6(1): 27-35 

Need AC, Ahmadi KR, Spector TD, Goldstein DB. Obesity is associated with genetic variants that alter dopamine availability . Ann Hum Genet 2006;70 (Pt3): 293-303

Hasset G, Hart DJ, Doyle D, March L, Spector TD. The relationship of progressive osteoarthritis of the knee and long-term progression of osteoarthritis of the hand, hip and lumbar spine. Ann Rheum Dis 2006;65(5): 623-8. 

Jiang J, Best S, Menzel S, Silver N, Lai MI, Surdulescu Gl, Spector TD, Thein SL. cMYB is involved in the regulation of fetal hemoglobin production in adults. Blood 2006; 108 (3):1077-1083. 

De Lange M, Andrew T, Snieder H, Ge D, Futers TS, Standeven K, Spector TD, Grant PJ, Ariens RAS. Joint linkage and association of 6 single nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus. Arterioscler Thromb Vasc Biol 2006; 26: 1914-1919. 

Spector TD, Ahmadi KR, Valdes AM. When is a replication not a replication? Or how to spot a good genetic association study. Arthritis & Rheumatism 2006; 54 (4): 1051-1054.

Paul SN, Kato BS, Cherkas LF, Andrew T, Spector TD. Heritability of the second to fourth digit ratio (2d:4d): A twin study. Twin Research and Human Genetics 2006; 9 (2): 215-219 

Valdes A, Van Oene M, Hart DJ, Surdulescu GL, Loughlin J, Doherty M, Spector TD. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis & Rheumatism 2006; 54 (2): 533-539 

Wilson S, Adam G, Langdown M, Reneland R, Braun A, Andrew T, Surdulescu GL, Norberg M, Dudbridge F, Reed PW, Sambrook P, Kleyn PW, Spector TD. Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in female dizygous twin cohort. European Journal of Human Genetics 2006; 14: 340-348. 

Garner C, Best S, Menzel S, Rooks H, Spector TD, Thein SL. Two candidate genes for low platelet count identified in an Asian indian kindred by genome-wide linkage analysis: glycoprotein IX and thrombopoietin. European Journal of Human Genetics 2006 ; 14 (1): 101-8.

Andrew T, Aviv A, Falchi M, Surdulescu GL, Gardner JP, LU X, Kimura M, Kato BS, Valdes AM, Spector TD. Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sib-pairs. American Journal of Human Genetics. January 2006; 78 (3):480-6. 

Sutcliffe A, Spoudeas HA, Devaki N, Bouloux P, Oliver T, Sambrook P, Bannister W, Lambalk CB, Spector TD. Comparison of serum FSH and inhibin B levels between adult male dizygotic and monozygotic twins. Human Reproduction 2006; 21: 447-450.

Jamshidi Y, Snieder H, Wang X, Spector TD. Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins. Diabetologia 2006; 49 (2): 306-310. 

Singer JJ, MacGregor AJ, Cherkas LF, Spector TD. Genetic influences on cognitive function using The Cambridge Neuropsychological Test Automated Battery. Intelligence 2006; 34:421-428 

Liew SH, Gilbert CE, Spector TD, Mellerio M, Kuijk FJ, Beatty S, Fitzke F, Marshall J, Hammond CJ. Central retinal thickness is positively correlated with macular pigment optical density. Exp Eye Res. 2006; 82 (5): 915-20. 

Aviv A, Valdes AM, Gardner JP, Swaminatahan R, Kimura M, Spector TD. Menopause modifies the association of telomere length in white blood cells with insulin resistance in normal females. The Journal of Clinical Endocrinology & Metabolism 2006; 91 (2): 635-40. 

Spector TD. Doxycycline and osteoarthritis: what does it show us? Nature Clinical Practice Rheumatology 2006; 2 (2):66-7 

Spector TD, Reneland RH, Mah S, Valdes AM, Hart DJ, Kammerer S, Langdown M, Hoyal CR, Atienza J, Doherty M, Rahman P, Nelson MR, Braun A. Association between a variation in LRCH1 and knee osteoarthritis: A genome-wide SNP association study using DVA pooling. Arthritis & Rheumatism 2006; 54 (2): 524-32. 

Stubbe JH, Boomsma DI, Vink JM, Cornes BK, Martin NG, Skytthe A, Kyvik KO, Rose RJ, Kujala UM, Kaprio J, Harris JR, Pedersen NL, Hunkin J, Spector TD, de Geus EJ. Genetic influences on exercise participation in 37,051 twin pairs from seven countries. PLoS ONE. 2006 Dec 20;1:e22. 

Blake GM, Knapp KM, Spector TD, Fogelman I. Predicting the risk of fracture at any site in the skeleton: are all bone mineral density measurement sites equally effective? Calcif Tissue Int. 2006; 78 (1): 9-17. 

Williams FMK, Andrew T, Saxne T, Heinegard D, Spector TD, MacGregor AJ. The heritable determinants of cartilage oligomeric matrix protein (COMP). Arthritis & Rheumatism 2006;54 (7):2147-51 

Maheu E, Altman RD, Bloch DA, Doherty M, Hochberg M, Mannoni A, Punzi L, Spector TD, Verbruggen G, Carr A, Cicuttini F, Dreiser RL, Haraoui BP, Hart D, Pelletier JP, Ramonda R, Rovati L. Design and conduct of clinical trials in patients with osteoarthritis of the hand: recommendations from a task force of the Osteoarthritis Research Society International. Osteoarthritis & Cartilage 2006; 14: 303-322. 

Paul SN, Kato BS, Hunkin JL, Vivekanandan S, Spector TD. The big finger: the second to fourth digit ratio is a predictor of sporting ability in women. British Journal of Sports Medicine 2006 Dec; 40 (12):981-3 

Cohen RM, Snieder H, Lindsell CJ, Beyan H, Hawa MI, Blinko S, Edwards R, Spector TD, Leslie RDG. Evidence for independent heritability of the glycation gap (glycosylation gap) fraction of HbA1c in nondiabetic twins. Diabetes Care 2006; 29 (8):1739-1743 

Singer JJ, Falchi M, MacGregor AJ, Cherkas LF, Spector TD. Genome-wide scan for prospective memory suggests linkage to chromosome 12q22. Behav Genet 2006 Jan; 36 (1):18-28.