2008

Anderson CA, Zhu G, Falchi M, van den Berg SM, Treloar SA, Spector TD, Martin NG, Boomsma DI, Visscher PM, Montgomery GW. A genome-wide linkage scan for age-at-menarche in three populations of European descent. J Clin Endocrinol Metab. 2008 October; 93 (10):3965-3970 

Andrew T, Maniatis N, Carbonaro F, Liew SH, Lau W, Spector TD, Hammond CJ. Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping. PLoS Genet. 2008 Oct;4(10):e1000220 

Bataille V, de Vries E. Melanoma-Part 1: epidemiology, risk factors, and prevention. BMJ. 2008 Nov 20;337:a2249 

Bruyere O, Delferriere D, Roux C, Wark JD, Spector T, Devogelaer JP, Brixen K, Adami S, Fechtenbaum J, Kolta S, Reginster JY. Effects of strontium ranelate on spinal osteoarthritis progression. Ann Rheum Dis. 2008 Mar;67(3):335-9. 

Burri AV, Spector TD. The genetics of female sexual behaviour. Sexuality, Reproduction and Menopause 2008; 8:23-27 

Carbonaro F, Andrew T, Mackey DA, Spector TD, Hammond CJ. Heritability of intraocular pressure: a classical twin study. Br J Ophthalmol. 2008 Aug;92(8):1125-8

Cherkas LF, Hunkin JL, Kato B, Richards B, Gardner JP, Surdulescu GL, Kimura M, Lu X, Spector TD, Aviv A. The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med 2008; 168 (2):154-158 

Chinappen-Horsley U, Blake GM, Fogelman I, Kato B, Ahmadi KR, Spector TD. Quantitative trait loci for bone lengths on chromosome 5 using dual energy X ray absorptiometry imaging in the twins UK cohort. PLOS One 2008; 3 (3):e1752 

Dalageorgou C, Ge D, Jamshidi Y, Nolte IM, Riese H, Savelieva I, Carter ND, Spector TD, Snieder H. Heritability of QT Interval: How Much Is Explained by Genes for Resting Heart Rate? J Cardiovasc Electrophysiol. 2008; 19 (4):386-91 

Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, Mychaleckyj JC, Todd JA, Bonella P, Fear AL, Lavant E, Louey A, Moonsamy P; Type 1 Diabetes Genetics Consortium. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes. 2008 Apr;57(4):1084-92

Falchi M. Analysis of quantitative trait loci. Methods Mol Biol. 2008;453:297-326.PMID: 18712311

Falchi M, Wilson SG, Paximadas D, Swaminathan R, Spector TD. Quantitative Linkage Analysis for Pancreatic B-cell Function and Insulin Resistance in a Large Twin Cohort. Diabetes. 2008;57 (4):1120-4 

Falchi M, Fuchsberger C. Jenti: An efficient tool for mining complex inbred genealogies.Bioinformatics. 2008 Mar 1;24(5):724-6 

Fogelman I, Fordham JN, Fraser WD, Spector TD, Christiansen C, Morris SA, Fox J. Parathyroid hormone(1-84) treatment of postmenopausal women with low bone mass receiving hormone replacement therapy. Calcif Tissue Int. 2008 Aug;83(2):85-92 

Fuchsberger C, Falchi M, Forer L, Pramstaller PP. PedVizApi: a Java API for the interactive, visual analysis of extended pedigrees.Bioinformatics. 2008 Jan 15;24(2):279-81 

Ge D, Gooljar SB, Kyriakou T, Collins LJ, Swaminathan R, Snieder H, Spector TD, O’Dell SD. Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile. Obesity Research 2008 Feb; 16 (2):492-6 

Goyenechea E, Collins LJ, Parra D, Liu G, Snieder H, Swaminathan R, Spector TD, Martínez JA, and O’Dell SD CD36 gene promoter polymorphisms are associated with low density lipoprotein-cholesterol in normal twins and after a low-calorie diet in obese subjects. Twin Research and Human Genetics 2008 Dec;11(6):621-8 

Harris JM, Cherkas LF, Kato BS, Spector TD, Heiman JR. Normal Variations in Personality are Associated with Coital Orgasmic Infrequency in Heterosexual Women: A Population-Based Study. J Sex Med. 2008 May;5(5):1177-83 

Healey P, Carbonaro F, Taylor B, Spector TD, Mitchell P, Hammond CJ. The heritability of optic disc parameters: a classic twin study. Invest Ophthalmol Vis Sci. 2008 Jan;49(1):77-80 

Healy DG, Falchi M, O’Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S, Ferreira JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Schapira AH, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW; International LRRK2. Consortium. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson’s disease: a case-control study. Lancet Neurol. 2008 Jul;7(7):583-90 

Kerkhof JM, Uitterlinden AG, Valdes AM, Hart DJ, Rivadeneira F, Jhamai M, Hofman A, Pols HA, Bierma-Zeinstra SM, Spector TD, van Meurs JB. Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. Osteoarthritis Cartilage. 2008 Oct;16(10):1141-9 

Keskitalo K, Tuorila H, Spector TD, Cherkas LF, Knaapila A, Kaprio J, Silventoinen K, Perola M. Three-factor eating questionnaire, body mass index, and responses to sweet and salty fatty foods: a twin study of genetic and environmental associations. American Journal of Clinical Nutrition 2008; 88:263-271 

Kimura M, Cherkas LF, Kato BS, Demissie S, Hjelmborg JB, Brimacombe M, Cupples A, Hunkin JL, Gardner JP, Lu X, Cao X, Sastrasinh M, Province MA, Hunt SC, Christensen K, Levy D, Spector TD, Aviv A. Offspring’s leukocyte telomere length, pPaternal age, and telomere elongation in sperm. PLoS Genet. 2008 Feb 15;4(2):e37 

Kyriakou T, Collins LJ, Spencer-Jones NJ, Malcolm C, Wang X, Snieder H, Swaminathan R, Burling KA, Hart DJ, Spector TD, O’Dell SD. Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity. J Hum Genet. 2008;53:718-727 

Liu YZ, Wilson SG, Wang L, Liu XG, Guo YF, Li J, Yan H, Deloukas P, Soranzo N, Chinnapen-Horsley U, Cervino A, Williams FM, Xiong DH, Zhang YP, Jin TB, Levy S, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Spector TD, Deng HW. Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. PLoS ONE. 2008 Sep 8;3(9):e3160.  PMCID: PMC2522269

Lundmark PE, Liljedahl U, Boomsma DI, Mannila H, Martin NG, Palotie A, Peltonen L, Perola M, Spector TD, Syvänen C. Evaluation of HapMap data in six populations of European Descent. European Journal of Human Genetics 2008 Sep;16(9):1142-50 

Lux S, Keller S, Mackay C, Ebers G, Marshall JC, Cherkas L, Rezaie R, Roberts N, Fink GR, Gurd JM.   Crossed cerebral lateralization  for verbal and visuo-spatial function in a pair of handedness discordantmonozygotic twins: MRI and fMRI brain imaging.  J Anat. 2008 Mar;212(3):235-48. PMCID:PMC2408986 

Mullin BH, Prince RL, Dick IM, Islam FM, Hart DJ, Spector TD, Devine A, Dudbridge F, Wilson SG. Bone structural effects of variation in the TNFRSF1B gene encoding the tumor necrosis factor receptor 2. Osteoporos Int. 2008 Jul; 19 (7):961-8 

Mullin BH, Prince RL, Dick IM, Hart DJ, Spector TD, Dudbridge F, Wilson SG. Identification of a Role for the ARHGEF3 Gene in Postmenopausal Osteoporosis.Am J Hum Genet. 2008 June; 82 (6):1262-9 

Nicolaou N, Shane S, Cherkas L, Hunkin J, Spector TD. Is the tendency to engage in entrepreneurship genetic? Management Science 2008;54 (1):167-179 

Nicolau N, Shane S, Cherkas L, Spector TD. The influence of sensation seeking in the heritability of entrepreneurship. Strat. Entrepreneurship J 2008; 2: 7-21

Olano-Martin E, Abraham EC, Gill-Garrison R, Valdes AM, Grimaldi K, Tang F, Jackson KG, Williams CM, Minihane AM. Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender. J Lipid Res. 2008 May;49(5):945-53 

Panicker V, Wilson SG, Spector TD, Brown SJ, Falchi M, Richards JB, Surdulescu GL, Lim EM, Fletcher SJ, Walsh JP. Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort. Clin Endocrinol (Oxf). 2008;68(4):652-9 

Panicker V, Wilson SG, Spector TD, Brown SJ, Kato BS, Reed PW, Falchi M, Richards JB, Surdulescu GL, Lim EM, Fletcher SJ, Walsh JP. Genetic Loci linked to pituitary-thyroid axis set points: a genome-wide scan of a large twin cohort. J Clin Endocrinol Metab. 2008 Sep;93(9):3519-2 

Prainsack B., Reardon J. and etc. Misdirected precaution. Nature Vol456|6 2008 Nov 6;456(7218):34-5 

Reginster JY, Felsenberg D, Boonen S, Diez-Perez A, Rizzoli R, Brandi ML, Spector TD, Brixen K, Goemaere S, Cormier C, Balogh A, Delmas PD, Meunier PJ. Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial. Arthritis Rheum. 2008 May 31;58(6):1687-1695 

Richards JB, Rivadeneira F, Inouye M, Pastinen TM, Soranzo N, Wilson SG, Andrew T, Falchi M, Gwilliam R, Ahmadi KR, Valdes AM, Arp P, Whittaker P, Verlaan DJ, Jhamai M, Kumanduri V, Moorhouse M, van Meurs JB, Hofman A, Pols HAP, Hart D, Zhai G, Kato BS, Mullin BH, Zhang F, Deloukas P, Uitterlinden AG, Spector TD. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. The Lancet 2008 May 3; 371(9623):1505-12 [PDF File] [Suppl PDF]

Richards JB, Valdes AM, Gardner JP, Kato BS, Siva A, Kimura M, Lu X, Brown MJ, Aviv A, Spector TD. Homocysteine levels and leukocyte telomere length. Atherosclerosis 2008 Oct; 200(2):271-7 

Richards JB, Yuan X, Geller F, Waterworth D, Bataille V, Glass D, Song K, Waeber G, Vollenweider P, Aben KK, Kiemeney LA, Walters B, Soranzo N, Thorsteinsdottir U, Kong A, Rafnar T, Deloukas P, Sulem P, Stefansson H, Stefansson K, Spector TD, Mooser V.Male-pattern baldness susceptibility locus at 20p11. Nature Genetics 2008, Nov; 40(11): 1282-1284 

Rodriguez-Lopez J, Pombo-Suarez M, Loughlin J, Tsezou A, Blanco FJ, Meulenbelt I, Slagboom PE, Valdes AM, Spector TD, Gomez-Reino JJ, Gonzalez A. Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. Osteoarthritis Cartilage. 2008 2009 Mar;17(3):321-7 

Seeman E, Devogelaer JP, Lorenc R, Spector T, Brixen K, Balogh A, Stucki G, Reginster JY. Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia. J Bone Miner Res. 2008 Mar;23(3):433-8 

Skidmore PM, Cassidy A, Swaminathan R, Richards JB, Spector TD, Macgregor AJ. Relation of birth weight, BMI and change in size from birth to adulthood to insulin resistance in a female twin cohort. J Clin Endocrinol Metab. 2008; 93(2):516-20 

Snieder H, Wang X, Shiri-Sverdlov R, van Vliet-Ostaptchouk JV, Hofker MH, Perks U, Spector TD, O’Dell SD. TUB is a candidate gene for late-onset obesity in women. Diabetologia. 2008 Jan;51(1):54-61 

Spector TD, Calomme MR, Anderson SH, Clement G, Bevan L, Demeester N, Swaminathan R, Jugdaohsingh R, Vanden Berghe DA, Powell JJ. Choline-stabilized orthosilicic acid supplementation as an adjunct to Calcium/Vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. BMC Musculoskelet Disord. 2008 Jun 11;9(1):85 

Thomson G, Barcellos LF, Valdes AM. Searching for additional disease loci in a genomic region. Adv Genet. 2008;60:253-92.

Valdes AM, Doherty M, Spector TD. The additive effect of individual genes in predicting risk of knee osteoarthritis. Annals of Rheumatic Diseas 2008 Jan; 67 (1):124-7 

Valdes AM, Loughlin J, Timms KM, van Meurs JJB, Southam L, Wilson SG, Doherty S, Lories RJ, Luyten FP, Gutin A, Abkevich V, Dongliang G, Hofman A, Uitterlinden AG, Hart DJ, Zhang F, Zhai G, Egli RJ, Doherty M, Lanchbury J, Spector TD. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. The American Journal of Human Genetics 2008; 82:1-10

Valdes AM, Spector TD, Doherty S, Wheeler M, Hart DJ, Doherty M. Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. Ann Rheum Dis. 2008 Dec 3 

Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Rheum Dis Clin North Am. 2008 Aug;34(3):581-603 

Vernon PA, Martin RA, Schermer JA, Cherkas LF, Spector TD. Genetic and environmental contributions to humor replication study. Twin Research and Human Genetics 2008; 11 (1): 44-47 

Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, Ahmadi KR et al. Genome-wide association study identifies novel genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. American Journal of Human Genetics 2008 Jan 10;82(1):139-149 

Whitehouse AJ, Spector TD, Cherkas LF. No clear genetic influences on the association between dyslexia and anxiety in a population-based sample of female twins. Dyslexia. 2008 Nov 24. 

Williams F, Cherkas L, Bertolaccini M, Murru V, Surdulescu G, Hughes G, Khamashta M, Spector T, Macgregor A. Migraine and antiphospholipid antibodies: no association found in migraine-discordant monozygotic twins. Cephalalgia. 2008 Oct; 28(10): 1048-52 

Williams FM, Kato BS, Livshits G, Sambrook PN, Spector TD, Macgregor AJ. Lumbar disc disease shows linkage to chromosome 19 overlapping with a QTL for hand OA. Ann Rheum Dis. 2008 Jan; 67 (1):117-9 

Williams FM, Spector TD. Biomarkers in osteoarthritis. Arthritis Res Ther. 2008 Jan 16;10(1):101 

Williams FM, Spector TD. Are intra-articular injections of hylan more effective than injections of hyaluronic acid for knee osteoarthritis? Nat Clin Pract Rheumatol. 2008 Aug;4(8):400-1 

Zhai G, Andrew T, Kato BS, Blake GM, Spector TD. Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin study. Osteoporos Int. 2009 Jun;20(6):949-53 

Zhai G, Hart DJ, Valdes AM, Kato BS, Richards JB, Hakim A , Spector TD. Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population based study. Osteoporosis International 2008 Aug;19(8):1211-7