Publications
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2011
Amin N, Byrne E, Johnson J, Chenevix-Trench G, Walter S, Nolte IM; kConFab Investigators, Vink JM, Rawal R, Mangino M, Teumer A, Keers JC, Verwoert G, Baumeister S, Biffar R, Petersmann A, Dahmen N, Doering A, Isaacs A, Broer L, Wray NR, Montgomery GW, Levy D, Psaty BM, Gudnason V, Chakravarti A, Sulem P, Gudbjartsson DF, Kiemeney LA, Thorsteinsdottir U, Stefansson K, van Rooij FJ, Aulchenko YS, Hottenga JJ, Rivadeneira FR, Hofman A, Uitterlinden AG, Hammond CJ, Shin SY, Ikram A, Witteman JC, Janssens AC, Snieder H, Tiemeier H, Wolfenbuttel BH, Oostra BA, Heath AC, Wichmann E, Spector TD, Grabe HJ, Boomsma DI, Martin NG, van Duijn CM. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Mol Psychiatry. 2011 Aug 30. [PDF File]
Andrew T, Calloway CD, Stuart S, Lee SH, Gill R, Clement G, Chowienczyk P, Spector TD, Valdes AM. A Twin Study of Mitochondrial DNA Polymorphisms Shows that Heteroplasmy at Multiple Sites Is Associated with mtDNA Variant 16093 but Not with Zygosity. PLoS One. 2011;6(8):e22332. Epub 2011 Aug 3 [PDF File]
Arora P, Garcia-Bailo B, Dastani Z, Brenner D, Villegas A, Malek S, Spector TD, Richards B, El-Sohemy A, Karmali M, Badawi A. Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes. BMC Med Genet. 2011 Jul 14;12(1):95 [PDF File]
Artigas MS, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV, Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez LM, Johnson T, Aldrich MC, Aspelund T, Barroso I, Campbell H, Cassano PA, Couper DJ, Eiriksdottir G, Franceschini N, Garcia M, Gieger C, Gislason GK, Grkovic I, Hammond CJ, Hancock DB, Harris TB, Ramasamy A, Heckbert SR, Heliövaara M, Homuth G, Hysi PG, James AL, Jankovic S, Joubert BR, Karrasch S, Klopp N, Koch B, Kritchevsky SB, Launer LJ, Liu Y, Loehr LR, Lohman K, Loos RJ, Lumley T, Al Balushi KA, Ang WQ, Barr RG, Beilby J, Blakey JD, Boban M, Boraska V, Brisman J, Britton JR, Brusselle GG, Cooper C, Curjuric I, Dahgam S, Deary IJ, Ebrahim S, Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson JL, Hardy R, Harris SE, Henderson J, Henry A, Hingorani AD, Hofman A, Holt PG, Hui J, Hunter ML, Imboden M, Jameson KA, Kerr SM, Kolcic I, Kronenberg F, Liu JZ, Marchini J, McKeever T, Morris AD, Olin AC, Porteous DJ, Postma DS, Rich SS, Ring SM, Rivadeneira F, Rochat T, Sayer AA, Sayers I, Sly PD, Smith GD, Sood A, Starr JM, Uitterlinden AG, Vonk JM, Wannamethee SG, Whincup PH, Wijmenga C, Williams OD, Wong A, Mangino M, Marciante KD, McArdle WL, Meibohm B, Morrison AC, North KE, Omenaas E, Palmer LJ, Pietiläinen KH, Pin I, Pola Sbreve Ek O, Pouta A, Psaty BM, Hartikainen AL, Rantanen T, Ripatti S, Rotter JI, Rudan I, Rudnicka AR, Schulz H, Shin SY, Spector TD, Surakka I, Vitart V, Völzke H, Wareham NJ, Warrington NM, Wichmann HE, Wild SH, Wilk JB, Wjst M, Wright AF, Zgaga L, Zemunik T, Pennell CE, Nyberg F, Kuh D, Holloway JW, Boezen HM, Lawlor DA, Morris RW, Probst-Hensch N; The International Lung Cancer Consortium; GIANT consortium, Kaprio J, Wilson JF, Hayward C, Kähönen M, Heinrich J, Musk AW, Jarvis DL, Gläser S, Järvelin MR, Ch Stricker BH, Elliott P, O'Connor GT, Strachan DP, London SJ, Hall IP, Gudnason V, Tobin MD. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet. 2011 Sep 25;43(11):1082-1090
Bell JT, Spector TD. A twin approach to unraveling epigenetics. Trends in Genetics. March 2011, 27 (3): 116-125 [PDF File]
Burri A, Cherkas L, Spector T, Rahman Q.Genetic and environmental influences on female sexual orientation, childhood gender typicality and adult gender identity. PLoS One. 2011;6(7):e21982. Epub 2011 Jul 7. [PDF File]
Burri A, Rahman Q, Spector T. Genetic and environmental risk factors for sexual distress and its association with female sexual dysfunction. Psychol Med. 2011 Jun 14:1-11 [PDF File]
Burri AV, Spector TD. An Epidemiological Survey of Post-Coital Psychological Symptoms in a UK Population Sample of Female Twins. Twin Res Hum Genet. 2011 Jun;14(3):240-8 [PDF File]
Burri A, Spector T. Recent and lifelong sexual dysfunction in a female UK population sample: prevalence and risk factors. J Sex Med. 2011 Sep;8(9):2420-30. [PDF File]
Cecelja M, Jiang B, Bevan L, Frost ML, Spector TD, Chowienczyk PJ. Arterial stiffening relates to arterial calcification but not to noncalcified atheroma in women a twin study. J Am Coll Cardiol. 2011 Mar 29;57(13):1480-6 [PDF File]
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Leach IM, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM; Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner JS. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.Nat Genet. 2011 Oct 16. [Epub ahead of print] [PDF File]
Chew S, Mullin BH, Lewis JR, Spector TD, Prince RL, Wilson SG. Homozygous deletion of the UGT2B17 gene is not associated with osteoporosis risk in elderly Caucasian women. Osteoporos Int 2011 Jun;22(6):1981-6. [PDF File]
Cooper JD, Smyth DJ, Walker NM, Stevens H, Burren OS, Wallace C, Greissl C, Ramos-Lopez E, Hypponen E, Dunger DB, Spector TD, Ouwehand WH, Wang TJ, Badenhoop K, Todd JA. Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes. Diabetes. 2011 May;60(5):1624-31 [PDF File]
Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Kerkhof HJ, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Loughlin J, McCaskie A, Ollier WE, Ralston SH, Spector TD, Wallis GA, Wilkinson JM, Aslam N, Birell F, Carluke I, Joseph J, Rai A, Reed M, Walker K; arcOGEN Consortium, Doherty SA, Jonsdottir I, Maciewicz RA, Muir KR, Metspalu A, Rivadeneira F, Stefansson K, Styrkarsdottir U, Uitterlinden AG, van Meurs JB, Zhang W, Valdes AM, Doherty M, Zeggini E. A Variant in MCF2L Is Associated with Osteoarthritis. Am J Hum Genet. 2011 Sep 9;89(3):446-50
Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, Pellikka N, Wallaschofski H, Kettunen J, Henneman P, Baumert J, Strachan DP, Fuchsberger C, Vitart V, Wilson JF, Paré G, Naitza S, Rudock ME, Surakka I, de Geus EJ, Alizadeh BZ, Guralnik J, Shuldiner A, Tanaka T, Zee RY, Schnabel RB, Nambi V, Kavousi M, Ripatti S, Nauck M, Smith NL, Smith AV, Sundvall J, Scheet P, Liu Y, Ruokonen A, Rose LM, Larson MG, Hoogeveen RC, Freimer NB, Teumer A, Tracy RP, Launer LJ, Buring JE, Yamamoto JF, Folsom AR, Sijbrands EJ, Pankow J, Elliott P, Keaney JF, Sun W, Sarin AP, Fontes JD, Badola S, Astor BC, Hofman A, Pouta A, Werdan K, Greiser KH, Kuss O, Meyer Zu Schwabedissen HE, Thiery J, Jamshidi Y, Nolte IM, Soranzo N, Spector TD, Völzke H, Parker AN, Aspelund T, Bates D, Young L, Tsui K, Siscovick DS, Guo X, Rotter JI, Uda M, Schlessinger D, Rudan I, Hicks AA, Penninx BW, Thorand B, Gieger C, Coresh J, Willemsen G, Harris TB, Uitterlinden AG, Järvelin MR, Rice K, Radke D, Salomaa V, Willems van Dijk K, Boerwinkle E, Vasan RS, Ferrucci L, Gibson QD, Bandinelli S, Snieder H, Boomsma DI, Xiao X, Campbell H, Hayward C, Pramstaller PP, van Duijn CM, Peltonen L, Psaty BM, Gudnason V, Ridker PM, Homuth G, Koenig W, Ballantyne CM, Witteman JC, Benjamin EJ, Perola M, Chasman DI. Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels. Circulation. 2011 Feb 22;123(7):731-8 [PDF File]
Demirkan A, Amin N, Isaacs A, Jarvelin MR, Whitfield JB, Wichmann HE, Kyvik KO, Rudan I, Gieger C, Hicks AA, Johansson A, Hottenga JJ, Smith JJ, Wild SH, Pedersen NL, Willemsen G, Mangino M, Hayward C, Uitterlinden AG, Hofman A, Witteman J, Montgomery GW, Pietiläinen KH, Rantanen T, Kaprio J, Döring A, Pramstaller PP, Gyllensten U, de Geus EJ, Penninx BW, Wilson JF, Rivadeneria F, Magnusson PK, Boomsma DI, Spector T, Campbell H, Hoehne B, Martin NG, Oostra BA, McCarthy M, Peltonen-Palotie L, Aulchenko Y, Visscher PM, Ripatti S, Janssens AC, van Duijn CM. Genetic architecture of circulating lipid levels. Eur J Hum Genet. 2011 Jul;19(7):813-9. [PDF File]
Duncan EL, Danoy P, Kemp JP, Leo PJ, McCloskey E, Nicholson GC, Eastell R, Prince RL, Eisman JA, Jones G, Sambrook PN, Reid IR, Dennison EM, Wark J, Richards JB, Uitterlinden AG, Spector TD, Esapa C, Cox RD, Brown SD, Thakker RV, Addison KA, Bradbury LA, Center JR, Cooper C, Cremin C, Estrada K, Felsenberg D, Glüer CC, Hadler J, Henry MJ, Hofman A, Kotowicz MA, Makovey J, Nguyen SC, Nguyen TV, Pasco JA, Pryce K, Reid DM, Rivadeneira F, Roux C, Stefansson K, Styrkarsdottir U, Thorleifsson G, Tichawangana R, Evans DM, Brown MA. Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet. 2011 Apr;7(4):e1001372. [PDF File]
Eastell R, Nagase S, Ohyama M, Small M, Sawyer J, Boonen S, Spector T, Kuwayama T, Deacon S. Safety and efficacy of the Cathepsin K inhibitor, ONO-5334, in postmenopausal osteoporosis - the OCEAN study. J Bone Miner Res. 2011 Jun;26(6):1303-12. [Published online]
Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Hua Zhao J, Aulchenko Y, Heath S, Sõber S, Parsa A, Luan J, Arora P, Dehghan A, Zhang F, Lucas G, Hicks AA, Jackson AU, Peden JF, Tanaka T, Wild SH, Rudan I, Igl W, Milaneschi Y, Parker AN, Fava C, Chambers JC, Fox ER, Kumari M, Jin Go M, van der Harst P, Hong Linda Kao W, Sjögren M, Vinay DG, Alexander M, Tabara Y, Shaw-Hawkins S, Whincup PH, Liu Y, Shi G, Kuusisto J, Tayo B, Seielstad M, Sim X, Hoang Nguyen KD, Lehtimäki T, Matullo G, Wu Y, Gaunt TR, Charlotte Onland-Moret N, Cooper MN, Platou CG, Org E, Hardy R, Dahgam S, Palmen J, Vitart V, Braund PS, Kuznetsova T, Uiterwaal CS, Adeyemo A, Palmas W, Campbell H, Ludwig B, Tomaszewski M, Tzoulaki I, Palmer ND, Aspelund T, Garcia M, Chang YP, O'Connell JR, Steinle NI, Grobbee DE, Arking DE, Kardia SL, Morrison AC, Hernandez D, Najjar S, McArdle WL, Hadley D, Brown MJ, Connell JM, Hingorani AD, Day IN, Lawlor DA, Beilby JP, Lawrence RW, Clarke R, Hopewell JC, Ongen H, Dreisbach AW, Li Y, Hunter Young J, Bis JC, Kähönen M, Viikari J, Adair LS, Lee NR, Chen MH, Olden M, Pattaro C, Hoffman Bolton JA, Köttgen A, Bergmann S, Mooser V, Chaturvedi N, Frayling TM, Islam M, Jafar TH, Erdmann J, Kulkarni SR, Bornstein SR, Grässler J, Groop L, Voight BF, Kettunen J, Howard P, Taylor A, Guarrera S, Ricceri F, Emilsson V, Plump A, Barroso I, Khaw KT, Weder AB, Hunt SC, Sun YV, Bergman RN, Collins FS, Bonnycastle LL, Scott LJ, Stringham HM, Peltonen L, Perola M, Vartiainen E, Brand SM, Staessen JA, Wang TJ, Burton PR, Soler Artigas M, Dong Y, Snieder H, Wang X, Zhu H, Lohman KK, Rudock ME, Heckbert SR, Smith NL, Wiggins KL, Doumatey A, Shriner D, Veldre G, Viigimaa M, Kinra S, Prabhakaran D, Tripathy V, Langefeld CD, Rosengren A, Thelle DS, Maria Corsi A, Singleton A, Forrester T, Hilton G, McKenzie CA, Salako T, Iwai N, Kita Y, Ogihara T, Ohkubo T, Okamura T, Ueshima H, Umemura S, Eyheramendy S, Meitinger T, Wichmann HE, Shin Cho Y, Kim HL, Lee JY, Scott J, Sehmi JS, Zhang W, Hedblad B, Nilsson P, Davey Smith G, Wong A, Narisu N, Stančáková A, Raffel LJ, Yao J, Kathiresan S, O'Donnell CJ, Schwartz SM, Arfan Ikram M, Longstreth Jr WT, Mosley TH, Seshadri S, Shrine NR, Wain LV, Morken MA, Swift AJ, Laitinen J, Prokopenko I, Zitting P, Cooper JA, Humphries SE, Danesh J, Rasheed A, Goel A, Hamsten A, Watkins H, Bakker SJ, van Gilst WH, Janipalli CS, Radha Mani K, Yajnik CS, Hofman A, Mattace-Raso FU, Oostra BA, Demirkan A, Isaacs A, Rivadeneira F, Lakatta EG, Orru M, Scuteri A, Ala-Korpela M, Kangas AJ, Lyytikäinen LP, Soininen P, Tukiainen T, Würtz P, Twee-Hee Ong R, Dörr M, Kroemer HK, Völker U, Völzke H, Galan P, Hercberg S, Lathrop M, Zelenika D, Deloukas P, Mangino M, Spector TD, Zhai G, Meschia JF, Nalls MA, Sharma P, Terzic J, Kranthi Kumar MV, Denniff M, Zukowska-Szczechowska E, Wagenknecht LE, Gerald R Fowkes F, Charchar FJ, Schwarz PE, Hayward C, Guo X, Rotimi C, Bots ML, Brand E, Samani NJ, Polasek O, Talmud PJ, Nyberg F, Kuh D, Laan M, Hveem K, Palmer LJ, van der Schouw YT, Casas JP, Mohlke KL, Vineis P, Raitakari O, Ganesh SK, Wong TY, Shyong Tai E, Cooper RS, Laakso M, Rao DC, Harris TB, Morris RW, Dominiczak AF, Kivimaki M, Marmot MG, Miki T, Saleheen D, Chandak GR, Coresh J, Navis G, Salomaa V, Han BG, Zhu X, Kooner JS, Melander O, Ridker PM, Bandinelli S, Gyllensten UB, Wright AF, Wilson JF, Ferrucci L, Farrall M, Tuomilehto J, Pramstaller PP, Elosua R, Soranzo N, Sijbrands EJ, Altshuler D, Loos RJ, Shuldiner AR, Gieger C, Meneton P, Uitterlinden AG, Wareham NJ, Gudnason V, Rotter JI, Rettig R, Uda M, Strachan DP, Witteman JC, Hartikainen AL, Beckmann JS, Boerwinkle E, Vasan RS, Boehnke M, Larson MG, Järvelin MR, Psaty BM, Abecasis GR, Chakravarti A, Elliott P, van Duijn CM, Newton-Cheh C, Levy D, Caulfield MJ, Johnson T. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. The International Consortium for Blood Pressure Genome-Wide Association Studies, Nature. 2011 Sep 11;478(7367):103-9. [PDF File]
Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories RJ, Karassa FB, Tylzanowski P, Bos SD; arcOGEN Consortium, Akune T, Arden NK, Carr A, Chapman K, Cupples LA, Dai J, Deloukas P, Doherty M, Doherty S, Engstrom G, Gonzalez A, Halldorsson BV, Hammond CL, Hart DJ, Helgadottir H, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Kaprio J, Kawaguchi H, Kisand K, Kloppenburg M, Kujala UM, Lohmander LS, Loughlin J, Luyten FP, Mabuchi A, McCaskie A, Nakajima M, Nilsson PM, Nishida N, Ollier WE, Panoutsopoulou K, van de Putte T, Ralston SH, Rivadeneira F, Saarela J, Schulte-Merker S, Shi D, Slagboom PE, Sudo A, Tamm A, Tamm A, Thorleifsson G, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Yoshimura N, Zeggini E, Zhai G, Zhang F, Jonsdottir I, Uitterlinden AG, Felson DT, van Meurs JB, Stefansson K, Ioannidis JP, Spector TD; Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA). Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis. 2011 Feb;70(2):349-55 [PDF File]
Fahy SJ, Sun C, Zhu G, Healey PR, Spector TD, Martin NG, Mitchell P, Wong TY, Mackey DA, Hammond CJ, Andrew T. The relationship between retinal arteriolar and venular calibers is genetically mediated and each is associated with risk of cardiovascular disease. Invest Ophthalmol Vis Sci 2011 Feb 23;52(2):975-81. [PDF File]
Fairweather-Tait SJ, Skinner J, Guile GR, Cassidy A, Spector TD, Macgregor AJ. Diet and bone mineral density study in postmenopausal women from the TwinsUK registry shows a negative association with a traditional English dietary pattern and a positive association with wine. Am J Clin Nutr. 2011 Nov; 94(5):1371-5 [PDF File]
Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP, Tayo BO, Mosley TH Jr, Lyon HN, Kang SJ, Rotimi CN, Cooper RS, Franceschini N, Curb JD, Martin LW, Eaton CB, Kardia SL, Taylor HA, Caulfield MJ, Ehret GB, Johnson T; The International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS); CARDIoGRAM consortium; CKDGen consortium; KidneyGen consortium; EchoGen consortium; CHARGE-HF consortium, Chakravarti A, Zhu X, Levy D. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011 Jun 1;20(11):2273-2284 [PDF File]
Ghebre MA, Hart DJ, Hakim AJ, Kato BS, Thompson V, Arden NK, Spector TD, Zhai G. Association between DHEAS and Bone Loss in Postmenopausal Women: A 15-Year Longitudinal Population-Based Study. Calcif Tissue Int. 2011 Oct;89(4):295-302. [PDF File]
Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y, Lopez LM, Mägi R, Meacham S, Okada Y, Pirastu N, Sorice R, Teumer A, Voss K, Zhang W, Ramirez-Solis R, Bis JC, Ellinghaus D, Gögele M, Hottenga JJ, Langenberg C, Kovacs P, O'Reilly PF, Shin SY, Esko T, Hartiala J, Kanoni S, Murgia F, Parsa A, Stephens J, van der Harst P, Ellen van der Schoot C, Allayee H, Attwood A, Balkau B, Bastardot F, Basu S, Baumeister SE, Biino G, Bomba L, Bonnefond A, Cambien F, Chambers JC, Cucca F, D'Adamo P, Davies G, de Boer RA, de Geus EJ, Döring A, Elliott P, Erdmann J, Evans DM, Falchi M, Feng W, Folsom AR, Frazer IH, Gibson QD, Glazer NL, Hammond C, Hartikainen AL, Heckbert SR, Hengstenberg C, Hersch M, Illig T, Loos RJ, Jolley J, Tee Khaw K, Kühnel B, Kyrtsonis MC, Lagou V, Lloyd-Jones H, Lumley T, Mangino M, Maschio A, Mateo Leach I, McKnight B, Memari Y, Mitchell BD, Montgomery GW, Nakamura Y, Nauck M, Navis G, Nöthlings U, Nolte IM, Porteous DJ, Pouta A, Pramstaller PP, Pullat J, Ring SM, Rotter JI, Ruggiero D, Ruokonen A, Sala C, Samani NJ, Sambrook J, Schlessinger D, Schreiber S, Schunkert H, Scott J, Smith NL, Snieder H, Starr JM, Stumvoll M, Takahashi A, Wilson Tang WH, Taylor K, Tenesa A, Lay Thein S, Tönjes A, Uda M, Ulivi S, van Veldhuisen DJ, Visscher PM, Völker U, Wichmann HE, Wiggins KL, Willemsen G, Yang TP, Hua Zhao J, Zitting P, Bradley JR, Dedoussis GV, Gasparini P, Hazen SL, Metspalu A, Pirastu M, Shuldiner AR, Joost van Pelt L, Zwaginga JJ, Boomsma DI, Deary IJ, Franke A, Froguel P, Ganesh SK, Jarvelin MR, Martin NG, Meisinger C, Psaty BM, Spector TD, Wareham NJ, Akkerman JW, Ciullo M, Deloukas P, Greinacher A, Jupe S, Kamatani N, Khadake J, Kooner JS, Penninger J, Prokopenko I, Stemple D, Toniolo D, Wernisch L, Sanna S, Hicks AA, Rendon A, Ferreira MA, Ouwehand WH, Soranzo N. New gene functions in megakaryopoiesis and platelet formation. Nature. 2011 Nov 30. doi: 10.1038/nature10659. [Epub ahead of print] [PDF File]
Goulston LM, Kiran A, Javaid MK, Soni A, White KM, Hart DJ, Spector TD, Arden NK. Obesity predicts knee pain over 14 years in women, independent of radiographic changes. Arthritis Care Res (Hoboken) 2011 Oct;63(10):1398-406. [Published online]
Jordan JM, Sowers MF, Messier SP, Bradley J, Arangio G, Katz JN, Losina E, Rovati L, Bachtell N, Cooper C, Spector T, Zhang W, Gardiner J, Wahba M. Methodologic Issues in Clinical Trials for Prevention or Risk Reduction in Osteoarthritis. Osteoarthritis Cartilage. 2011 May;19(5):500-8. [PDF File]
Iervolino AC, Rijsdijk FV, Cherkas L, Fullana MA, Mataix-Cols D. A multivariate twin study of obsessive-compulsive symptom dimensions. Arch Gen Psychiatry. 2011 Jun;68(6):637-44 [PDF File]
Kato BS, Nicholson G, Neiman M, Rantalainen M, Holmes CC, Barrett A, Uhlen M, Nilsson P, Spector TD, Schwenk JM. Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. Proteome Sci. 2011 Nov 17;9(1):73. [Epub ahead of print]
Kerkhof HJ, Doherty M, Arden NK, Abramson SB, Attur M, Bos SD, Cooper C, Dennison EM, Doherty SA, Evangelou E, Hart DJ, Hofman A, Javaid K, Kerna I, Kisand K, Kloppenburg M, Krasnokutsky S, Maciewicz RA, Meulenbelt I, Muir KR, Rivadeneira F, Samuels J, Sezgin M, Slagboom E, Smith AJ, Spector TD, Tamm A, Tamm A, Uitterlinden AG, Wheeler M, Zhai G, Zhang W, van Meurs JB, Valdes AM. Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis. Osteoarthritis Cartilage. 2011 Mar;19(3):265-71 [PDF File]
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Livshits G, Popham M, Malkin I, Sambrook PN, Macgregor AJ, Spector T, Williams FM. Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study. Ann Rheum Dis. 2011 Oct;70(10):1740-5. [PDF File]
Marzi C, Albrecht E, Hysi PG, Lagou V, Waldenberger M, Tönjes A, Prokopenko I, Heim K, Blackburn H, Ried JS, Kleber ME, Mangino M, Thorand B, Peters A, Hammond CJ, Grallert H, Boehm BO, Kovacs P, Geistlinger L, Prokisch H, Winkelmann BR, Spector TD, Wichmann HE, Stumvoll M, Soranzo N, März W, Koenig W, Illig T, Gieger C. Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A. PLoS Genet. 2010 Nov 18;6(11):e1001213 [PDF File]
Min JL, Taylor JM, Richards JB, Watts T, Pettersson FH, Broxholme J, Ahmadi KR, Surdulescu GL, Lowy E, Gieger C, Newton-Cheh C, Perola M, Soranzo N, Surakka I, Lindgren CM, Ragoussis J, Morris AP, Cardon LR, Spector TD, Zondervan KT. The Use of Genome-Wide eQTL Associations in Lymphoblastoid Cell Lines to Identify Novel Genetic Pathways Involved in Complex Traits. PLoS One. 2011;6(7):e22070. Epub 2011 Jul 15 [Published online]. [PDF File]
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Nicholls AS, Kiran A, Pollard TC, Hart D, Arden CP, Spector T, Gill HS, Murray DW, Carr AJ, Arden NK. The association between hip morphology parameters and 19-year risk of end-stage osteoarthritis in the hip: A nested case-control study. Arthritis Rheum. 2011 Nov;63(11):3392-400. [PDF File]
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Obeidat M, Wain LV, Shrine N, Kalsheker N, Artigas MS, Repapi E, Burton PR, Johnson T, Ramasamy A, Zhao JH, Zhai G, Huffman JE, Vitart V, Albrecht E, Igl W, Hartikainen AL, Pouta A, Cadby G, Hui J, Palmer LJ, Hadley D, McArdle WL, Rudnicka AR, Barroso I, Loos RJ, Wareham NJ, Mangino M, Soranzo N, Spector TD, Gläser S, Homuth G, Völzke H, Deloukas P, Granell R, Henderson J, Grkovic I, Jankovic S, Zgaga L, Polašek O, Rudan I, Wright AF, Campbell H, Wild SH, Wilson JF, Heinrich J, Imboden M, Probst-Hensch NM, Gyllensten U, Johansson A, Zaboli G, Mustelin L, Rantanen T, Surakka I, Kaprio J, Jarvelin MR, Hayward C, Evans DM, Koch B, Musk AW, Elliott P, Strachan DP, Tobin MD, Sayers I, Hall IP, Consortium S. A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample. PLoS One. 2011;6(5):e19382. [PDF File]
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Perroud N, Guipponi M, Pertusa A, Fullana MA, Iervolino AC, Cherkas L, Spector T, Collier D, Mataix-Cols D. Genome-wide association study of hoarding traits. Am J Med Genet B Neuropsychiatr Genet. 2011 Mar;156(2):240-2 [PDF File]
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Southam L, Panoutsopoulou K, Rayner NW, Chapman K, Durrant C, Ferreira T, Arden N, Carr A, Deloukas P, Doherty M, Loughlin J, McCaskie A, Ollier WE, Ralston S, Spector TD, Valdes AM, Wallis GA, Wilkinson JM; the arcOGEN consortium, Marchini J, Zeggini E. The effect of genome-wide association scan quality control on imputation outcome for common variants. Eur J Hum Genet 2011 May;19(5):610-4. [PDF File]
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Valdes AM, De Wilde G, Doherty SA, Lories RJ, Vaughn FL, Laslett LL, Maciewicz RA, Soni A, Hart DJ, Zhang W, Muir KR, Dennison EM, Wheeler M, Leaverton P, Cooper C, Spector TD, Cicuttini FM, Chapman V, Jones G, Arden NK, Doherty M. The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis. Ann Rheum Dis. 2011 Sep;70(9):1556-61. [PDF File]
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Valdes AM, Spector TD. Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol. 2011 Jan;7(1):23-32 [PDF File]
Valdes AM, Styrkarsdottir U, Doherty M, Morris DL, Mangino M, Tamm A, Doherty SA, Kisand K, Kerna I, Tamm A, Wheeler M, Maciewicz RA, Zhang W, Muir KR, Dennison EM, Hart DJ, Metrustry S, Jonsdottir I, Jonsson GF, Jonsson H, Ingvarsson T, Cooper C, Vyse TJ, Spector TD, Stefansson K, Arden NK. Large Scale Replication Study of the Association between HLA Class II/BTNL2 Variants and Osteoarthritis of the Knee in European-Descent Populations. PLoS One. 2011;6(8):e23371 [PDF File]
Vink JM, Boomsma DI, Medland SE, de Moor MH, Stubbe JH, Cornes BK, Martin NG, Skytthea A, Kyvik KO, Rose RJ, Kujala UM, Kaprio J, Harris JR, Pedersen NL, Cherkas L, Spector TD, de Geus EJ. Variance components models for physical activity with age as modifier: a comparative twin study in seven countries. Twin Res Hum Genet. 2011 Feb;14(1):25-34
Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM, Henneman P, Smith AV, Ehret GB, Amin N, Larson MG, Mooser V, Hadley D, Dörr M, Bis JC, Aspelund T, Esko T, Janssens AC, Zhao JH, Heath S, Laan M, Fu J, Pistis G, Luan J, Arora P, Lucas G, Pirastu N, Pichler I, Jackson AU, Webster RJ, Zhang F, Peden JF, Schmidt H, Tanaka T, Campbell H, Igl W, Milaneschi Y, Hottenga JJ, Vitart V, Chasman DI, Trompet S, Bragg-Gresham JL, Alizadeh BZ, Chambers JC, Guo X, Lehtimäki T, Kühnel B, Lopez LM, Polašek O, Boban M, Nelson CP, Morrison AC, Pihur V, Ganesh SK, Hofman A, Kundu S, Mattace-Raso FU, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Hwang SJ, Vasan RS, Wang TJ, Bergmann S, Vollenweider P, Waeber G, Laitinen J, Pouta A, Zitting P, McArdle WL, Kroemer HK, Völker U, Völzke H, Glazer NL, Taylor KD, Harris TB, Alavere H, Haller T, Keis A, Tammesoo ML, Aulchenko Y, Barroso I, Khaw KT, Galan P, Hercberg S, Lathrop M, Eyheramendy S, Org E, Sõber S, Lu X, Nolte IM, Penninx BW, Corre T, Masciullo C, Sala C, Groop L, Voight BF, Melander O, O'Donnell CJ, Salomaa V, d'Adamo AP, Fabretto A, Faletra F, Ulivi S, Del Greco M F, Facheris M, Collins FS, Bergman RN, Beilby JP, Hung J, Musk AW, Mangino M, Shin SY, Soranzo N, Watkins H, Goel A, Hamsten A, Gider P, Loitfelder M, Zeginigg M, Hernandez D, Najjar SS, Navarro P, Wild SH, Corsi AM, Singleton A, de Geus EJ, Willemsen G, Parker AN, Rose LM, Buckley B, Stott D, Orru M, Uda M; LifeLines Cohort Study, van der Klauw MM, Zhang W, Li X, Scott J, Chen YD, Burke GL, Kähönen M, Viikari J, Döring A, Meitinger T, Davies G, Starr JM, Emilsson V, Plump A, Lindeman JH, Hoen PA, König IR; EchoGen consortium, Felix JF, Clarke R, Hopewell JC, Ongen H, Breteler M, Debette S, Destefano AL, Fornage M; AortaGen Consortium, Mitchell GF; CHARGE Consortium Heart Failure Working Group, Smith NL; KidneyGen consortium, Holm H, Stefansson K, Thorleifsson G, Thorsteinsdottir U; CKDGen consortium; Cardiogenics consortium; CardioGram, Samani NJ, Preuss M, Rudan I, Hayward C, Deary IJ, Wichmann HE, Raitakari OT, Palmas W, Kooner JS, Stolk RP, Jukema JW, Wright AF, Boomsma DI, Bandinelli S, Gyllensten UB, Wilson JF, Ferrucci L, Schmidt R, Farrall M, Spector TD, Palmer LJ, Tuomilehto J, Pfeufer A, Gasparini P, Siscovick D, Altshuler D, Loos RJ, Toniolo D, Snieder H, Gieger C, Meneton P, Wareham NJ, Oostra BA, Metspalu A, Launer L, Rettig R, Strachan DP, Beckmann JS, Witteman JC, Erdmann J, van Dijk KW, Boerwinkle E, Boehnke M, Ridker PM, Jarvelin MR, Chakravarti A, Abecasis GR, Gudnason V, Newton-Cheh C, Levy D, Munroe PB, Psaty BM, Caulfield MJ, Rao DC, Tobin MD, Elliott P, van Duijn CM. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet. Nat Genet. 2011 Sep 11;43(10):1005-11 [PDF File]
Williams FM, Popham M, Hart DJ, de Schepper E, Bierma-Zeinstra S, Hofman A, Uitterlinden AG, Arden NK, Cooper C, Spector TD, Valdes AM, van Meurs J. GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women. Arthritis Rheum. 2011 Mar;63(3):708-12 [PDF File]
Williams FM, Popham M, Sambrook PN, Jones AF, Spector TD, Macgregor AJ. Progression of lumbar disc degeneration over a decade: a heritability study. Ann Rheum Dis. 2011 Jul;70(7):1203-7. [PDF File]
Zhai G, Teumer A, Stolk L, Perry JR, Vandenput L, Coviello AD, Koster A, Bell JT, Bhasin S, Eriksson J, Eriksson A, Ernst F, Ferrucci L, Frayling TM, Glass D, Grundberg E, Haring R, Hedman AK, Hofman A, Kiel DP, Kroemer HK, Liu Y, Lunetta KL, Maggio M, Lorentzon M, Mangino M, Melzer D, Miljkovic I; MuTHER Consortium, Nica A, Penninx BW, Vasan RS, Rivadeneira F, Small KS, Soranzo N, Uitterlinden AG, Völzke H, Wilson SG, Xi L, Zhuang WV, Harris TB, Murabito JM, Ohlsson C, Murray A, de Jong FH, Spector TD, Wallaschofski H. Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms. PLoS Genet. 2011 Apr;7(4):e1002025. Epub 2011 Apr 14. PubMed PMID: 21533175; PubMed Central PMCID: PMC3077384. [PDF File]
Zheng HF, Spector TD, Richards JB. Insights into the genetics of osteoporosis from recent genome-wide association studies. Expert Rev Mol Med. 2011 Aug 26;13:e28. [PDF File]
2010
Burri AV, Cherkas L, Spector TD. Genetic and Environmental Influences on self-reported G-Spots in Women: A Twin Study. J Sex Med. 2010 May;7(5):1842-52. [PDF File]
Burri AV, Cherkas L, Spector TD. Exploring genetic and environmental influences on miscarriage rates: a twin study.Twin Res Hum Genet. 2010 Apr;13(2):201-6. [PDF File]
Burri A, Cherkas L, Spector T. Replication of Psychometric Properties of the FSFI and Validation of a Modified Version (FSFI-LL) Assessing Lifelong Sexual Function in an Unselected Sample of Females. J Sex Med. 2010 Dec;7(12):3929-39.
Carbonaro F, Andrew T, Mackey DA, Spector TD, Hammond CJ. Comparison of 3 methods of Intraocular Pressure measurement and their relation to Central Corneal Thickness. Eye (Lond). 2010 Jul;24(7):1165-70 [PDF File]
Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJL, Beckmann J, Bilo HJG, Bochud M, Brown MJ, Caulfield MJ, Connell JMC, Cook HT, Cotlarciuc I, Smith GD, de Silva R, Deng G, Devuyst O, Dikkeschei LD, Dimkovic N, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Ferrucci L, Floege J, Forouhi NG, Gansevoort RT, Han X, Hedblad B, van der Heide JJH, Hepkema BG, Hernandez-Fuentes M, Hypponen E, Toby Johnson33, de Jong PE, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos RJF, Luan J, Luttropp K, Maréchal C, Melander O, Munroe PB, Nordfors L, Parsa A, Peltonen L, Penninx BW, Perucha E, Pouta A, Prokopenko I, Roderick PJ, Ruokonen A, Samani NJ, Sanna S, Schalling M, Schlessinger D, Schlieper G, Seelen MAJ, Shuldiner AR, Sjögren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg MJE, Swaminathan R, Tanaka T, Ubink-Veltmaat LJ, Uda M, Vollenweider P, Wallace C, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin M, Mooser V, Abecasis GR, Lightstone L, Scott J, Navis G, Elliott P, Kooner JS. Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics 2010 May;42(5):373-5 [PDF File]
Cherkas LF, Harris JM, Levinson E, Spector TD, Prainsack B. A survey of UK public interest in internet-based personal genome testing. PLoS One. 2010 Oct 19;5(10):e13473. [PDF File]
Codd V, Mangino M, van der Harst P, Braund PS, Kaiser M, Beveridge AJ, Rafelt S, Moore J, Nelson C, Soranzo N, Zhai G, Valdes AM, Blackburn H, Leach IM, de Boer RA; Wellcome Trust Case Control Consortium, Goodall AH, Ouwehand W, van Veldhuisen DJ, van Gilst WH, Navis G, Burton PR, Tobin MD, Hall AS, Thompson JR, Spector T, Samani NJ. Common variants near TERC are associated with mean telomere length. Nat Genet. 2010 Mar;42(3):197-9 [PDF File]
Collette J, Bruyère O, Kaufman JM, Lorenc R, Felsenberg D, Spector TD, Diaz-Curiel M, Boonen S, Reginster JY. Vertebral anti-fracture efficacy of strontium ranelate according to pre-treatment bone turnover. Osteoporos Int. 2010 Feb;21(2):233-41 [PDF File]
Duffy DL, Iles MM, Glass D, Zhu G, Barrett JH, Höiom V, Zhao ZZ, Sturm RA, Soranzo N, Hammond C, Kvaskoff M, Whiteman DC, Mangino M, Hansson J, Newton-Bishop JA; GenoMEL, Bataille V, Hayward NK, Martin NG, Bishop DT, Spector TD, Montgomery GW. IRF4 variants have age-specific effects on nevus count and predispose to melanoma. Am J Hum Genet. 2010 Jul 9;87(1):6-16. [PDF File]
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, Elliott P, Rybin D, Thorleifsson G, Steinthorsdottir V, Henneman P, Grallert H, Dehghan A, Hottenga JJ, Franklin CS, Navarro P, Song K, Goel A, Perry JRB, Egan JM, Lajunen T, Grarup N, Sparsø T, Doney A, Voight BF, Stringham HM, Li M, Kanoni S, Shrader P, Cavalcanti-Proença C, Kumari M, Qi L, Timpson NJ, Gieger C, Zabena C, Rocheleau G, Ingelsson E, An P, O’Connell J, Luan J, Elliott A, McCarroll SA, Payne F, Roccasecca RM, Pattou F, Sethupathy P, Ardlie K, Ariyurek Y, Balkau B, Barter P, Beilby JP, Ben-Shlomo Y, Benediktsson R, Bennett AJ, Bergmann S, Bochud M, Boerwinkle E, Bonnefond A, Bonnycastle LL, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Charpentier G, Chen Y, Chines P, Clarke R, Coin LJM, Cooper MN, Cornelis M, Crawford G, Crisponi L, Day INM, de Geus Eco, D, Dina C, Erdos MR, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Fox CS, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Groves CJ, Grundy S, Gwilliam R, Gyllensten U, Hadjadj S, Hallmans G, Hammond N, Han X, Hartikainen A, Hassanali N, Hayward C, Heath SC, Hercberg S, Herder C, Hicks AA, Hillman DR, Hingorani AD, Hofman A, Hui J, Hung J, Isomaa B, Johnson PRV, Jørgensen T, Jula A, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Bacquer OL, Lecoeur C, Li Y, Lyssenko V, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McCulloch LJ, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Morken MA, Mukherjee S, Naitza S, Narisu N, Neville MJ, Oostra BA, Orrù M, Pakyz R, Palmer CNA, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Perola M, Pfeiffer AFH, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Psaty BM, Rathmann W, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Roden M, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Scott LJ, Seedorf U, Sharp SJ, Shields B, Sigurðsson G, Sijbrands EJG, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen A, Tanaka T, Thorand B, Tichet J, Tönjes A, Tuomi T, Uitterlinden AG, van Dijk KW, van Hoek M, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Walters GB, Ward KL, Watkins H, Weedon MN, Wild SH, Willemsen G, Witteman JCM, Yarnell JWG, Zeggini E, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, DIAGRAM Consortium, GIANT Consortium, Global BPGen Consortium, Borecki IB, Loos RJF, Meneton P, Magnusson PKE, Nathan DM, Williams GH, Hattersley AT, Silander K, Salomaa V, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Dedoussis GV, Serrano-Ríos M, Morris AD, Lind L, Palmer LJ, Hu FB, Franks PW, Ebrahim S, Marmot M, Kao WHL, Pankow JS, Sampson MJ, Kuusisto J, Laakso M, Hansen T, Pedersen O, Pramstaller PP, Wichmann HE, Illig T, Rudan I, Wright AF, Stumvoll M, Campbell H, Wilson JF, Hamsten A on behalf of Procardis consortium, Bergman RN, Buchanan TA, Collins FS, Mohlke KL, Tuomilehto J, Valle TT, Altshuler D, Rotter JI, Siscovick DS, J BW, Penninx H, Boomsma D, Deloukas P, Spector TD, Frayling TM, Ferrucci L, Kong A, Thorsteinsdottir U, Stefansson K, van Duijn CM, Aulchenko YS, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin M, Waterworth DM, Vollenweider P, Peltonen L, Mooser V, Abecasis GR, Wareham NJ, Sladek R, Froguel P, Watanabe RM, Meigs JB, Groop L, Boehnke M, McCarthy M, Florez JC and Barroso I for the MAGIC investigators. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010 Feb;42(2):105-16 [PDF File]
Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, de Bakker PI, Müller M, Morrison AC, Smith AV, Isaacs A, Sanna S, Dörr M, Navarro P, Fuchsberger C, Nolte IM, de Geus EJ, Estrada K, Hwang SJ, Bis JC, Rückert IM, Alonso A, Launer LJ, Hottenga JJ, Rivadeneira F, Noseworthy PA, Rice KM, Perz S, Arking DE, Spector TD, Kors JA, Aulchenko YS, Tarasov KV, Homuth G, Wild SH, Marroni F, Gieger C, Licht CM, Prineas RJ, Hofman A, Rotter JI, Hicks AA, Ernst F, Najjar SS, Wright AF, Peters A, Fox ER, Oostra BA, Kroemer HK, Couper D, Völzke H, Campbell H, Meitinger T, Uda M, Witteman JC, Psaty BM, Wichmann HE, Harris TB, Kääb S, Siscovick DS, Jamshidi Y, Uitterlinden AG, Folsom AR, Larson MG, Wilson JF, Penninx BW, Snieder H, Pramstaller PP, van Duijn CM, Lakatta EG, Felix SB, Gudnason V, Pfeufer A, Heckbert SR, Stricker BH, Boerwinkle E, O'Donnell CJ. Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet. 2010 Oct 1;19(19):3885-94 [PDF File]
Elks CE, Perry JR, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, Gudbjartsson DF, Esko T, Feenstra B, Hottenga JJ, Koller DL, Kutalik Z, Lin P, Mangino M, Marongiu M, McArdle PF, Smith AV, Stolk L, van Wingerden SH, Zhao JH, Albrecht E, Corre T, Ingelsson E, Hayward C, Magnusson PK, Smith EN, Ulivi S, Warrington NM, Zgaga L, Alavere H, Amin N, Aspelund T, Bandinelli S, Barroso I, Berenson GS, Bergmann S, Blackburn H, Boerwinkle E, Buring JE, Busonero F, Campbell H, Chanock SJ, Chen W, Cornelis MC, Couper D, Coviello AD, d'Adamo P, de Faire U, de Geus EJ, Deloukas P, Döring A, Smith GD, Easton DF, Eiriksdottir G, Emilsson V, Eriksson J, Ferrucci L, Folsom AR, Foroud T, Garcia M, Gasparini P, Geller F, Gieger C, Consortium TG, Gudnason V, Hall P, Hankinson SE, Ferreli L, Heath AC, Hernandez DG, Hofman A, Hu FB, Illig T, Järvelin MR, Johnson AD, Karasik D, Khaw KT, Kiel DP, Kilpeläinen TO, Kolcic I, Kraft P, Launer LJ, Laven JS, Li S, Liu J, Levy D, Martin NG, McArdle WL, Melbye M, Mooser V, Murray JC, Murray SS, Nalls MA, Navarro P, Nelis M, Ness AR, Northstone K, Oostra BA, Peacock M, Palmer LJ, Palotie A, Paré G, Parker AN, Pedersen NL, Peltonen L, Pennell CE, Pharoah P, Polasek O, Plump AS, Pouta A, Porcu E, Rafnar T, Rice JP, Ring SM, Rivadeneira F, Rudan I, Sala C, Salomaa V, Sanna S, Schlessinger D, Schork NJ, Scuteri A, Segrè AV, Shuldiner AR, Soranzo N, Sovio U, Srinivasan SR, Strachan DP, Tammesoo ML, Tikkanen E, Toniolo D, Tsui K, Tryggvadottir L, Tyrer J, Uda M, van Dam RM, van Meurs JB, Vollenweider P, Waeber G, Wareham NJ, Waterworth DM, Weedon MN, Wichmann HE, Willemsen G, Wilson JF, Wright AF, Young L, Zhai G, Zhuang WV, Bierut LJ, Boomsma DI, Boyd HA, Crisponi L, Demerath EW, van Duijn CM, Econs MJ, Harris TB, Hunter DJ, Loos RJ, Metspalu A, Montgomery GW, Ridker PM, Spector TD, Streeten EA, Stefansson K, Thorsteinsdottir U, Uitterlinden AG, Widen E, Murabito JM, Ong KK, Murray A. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet. 2010 Dec;42(12):1077-85 [PDF File]
Ferreira MA, Mangino M, Brumme CJ, Zhao ZZ, Medland SE, Wright MJ, Nyholt DR, Gordon S, Campbell M, McEvoy BP, Henders A, Evans DM, Lanchbury JS, Pereyra F; International HIV Controllers Study, Walker BD, Haas DW, Soranzo N, Spector TD, de Bakker PI, Frazer IH, Montgomery GW, Martin NG. Quantitative Trait Loci for CD4:CD8 Lymphocyte Ratio Are Associated with Risk of Type 1 Diabetes and HIV-1 Immune Control. Am J Hum Genet.2010 Jan;86(1):88-92 [PDF File]
Glass D, Parts L, Knowles D, Aviv A, Spector TD. No Correlation Between Childhood Maltreatment and Telomere Length. Biol Psychiatry. 2010 Sep 15;68(6):e21-2 [PDF File]
Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpeläinen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Holmes CC, Kaplan LM, Liang L, Min JL, Moffatt MF, Molony C, Nicholson G, Schadt EE, Zondervan KT, Feitosa MF, Ferreira T, Allen HL, Weyant RJ, Wheeler E, Wood AR; MAGIC, Estrada K, Goddard ME, Lettre G, Mangino M, Nyholt DR, Purcell S, Smith AV, Visscher PM, Yang J, McCarroll SA, Nemesh J, Voight BF, Absher D, Amin N, Aspelund T, Coin L, Glazer NL, Hayward C, Heard-Costa NL, Hottenga JJ, Johansson A, Johnson T, Kaakinen M, Kapur K, Ketkar S, Knowles JW, Kraft P, Kraja AT, Lamina C, Leitzmann MF, McKnight B, Morris AP, Ong KK, Perry JR, Peters MJ, Polasek O, Prokopenko I, Rayner NW, Ripatti S, Rivadeneira F, Robertson NR, Sanna S, Sovio U, Surakka I, Teumer A, van Wingerden S, Vitart V, Zhao JH, Cavalcanti-Proença C, Chines PS, Fisher E, Kulzer JR, Lecoeur C, Narisu N, Sandholt C, Scott LJ, Silander K, Stark K, Tammesoo ML, Teslovich TM, Timpson NJ, Watanabe RM, Welch R, Chasman DI, Cooper MN, Jansson JO, Kettunen J, Lawrence RW, Pellikka N, Perola M, Vandenput L, Alavere H, Almgren P, Atwood LD, Bennett AJ, Biffar R, Bonnycastle LL, Bornstein SR, Buchanan TA, Campbell H, Day IN, Dei M, Dörr M, Elliott P, Erdos MR, Eriksson JG, Freimer NB, Fu M, Gaget S, Geus EJ, Gjesing AP, Grallert H, Gräßler J, Groves CJ, Guiducci C, Hartikainen AL, Hassanali N, Havulinna AS, Herzig KH, Hicks AA, Hui J, Igl W, Jousilahti P, Jula A, Kajantie E, Kinnunen L, Kolcic I, Koskinen S, Kovacs P, Kroemer HK, Krzelj V, Kuusisto J, Kvaloy K, Laitinen J, Lantieri O, Lathrop GM, Lokki ML, Luben RN, Ludwig B, McArdle WL, McCarthy A, Morken MA, Nelis M, Neville MJ, Paré G, Parker AN, Peden JF, Pichler I, Pietiläinen KH, Platou CG, Pouta A, Ridderstråle M, Samani NJ, Saramies J, Sinisalo J, Smit JH, Strawbridge RJ, Stringham HM, Swift AJ, Teder-Laving M, Thomson B, Usala G, van Meurs JB, van Ommen GJ, Vatin V, Volpato CB, Wallaschofski H, Walters GB, Widen E, Wild SH, Willemsen G, Witte DR, Zgaga L, Zitting P, Beilby JP, James AL, Kähönen M, Lehtimäki T, Nieminen MS, Ohlsson C, Palmer LJ, Raitakari O, Ridker PM, Stumvoll M, Tönjes A, Viikari J, Balkau B, Ben-Shlomo Y, Bergman RN, Boeing H, Smith GD, Ebrahim S, Froguel P, Hansen T, Hengstenberg C, Hveem K, Isomaa B, Jørgensen T, Karpe F, Khaw KT, Laakso M, Lawlor DA, Marre M, Meitinger T, Metspalu A, Midthjell K, Pedersen O, Salomaa V, Schwarz PE, Tuomi T, Tuomilehto J, Valle TT, Wareham NJ, Arnold AM, Beckmann JS, Bergmann S, Boerwinkle E, Boomsma DI, Caulfield MJ, Collins FS, Eiriksdottir G, Gudnason V, Gyllensten U, Hamsten A, Hattersley AT, Hofman A, Hu FB, Illig T, Iribarren C, Jarvelin MR, Kao WH, Kaprio J, Launer LJ, Munroe PB, Oostra B, Penninx BW, Pramstaller PP, Psaty BM, Quertermous T, Rissanen A, Rudan I, Shuldiner AR, Soranzo N, Spector TD, Syvanen AC, Uda M, Uitterlinden A, Völzke H, Vollenweider P, Wilson JF, Witteman JC, Wright AF, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, Frayling TM, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, North KE, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, Hirschhorn JN, Assimes TL, Wichmann HE, Thorsteinsdottir U, van Duijn CM, Stefansson K, Cupples LA, Loos RJ, Barroso I, McCarthy MI, Fox CS, Mohlke KL, Lindgren CM. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010 Nov;42(11):949-960 [PDF File]
Hsu YH, Zillikens MC, Wilson SG, Farber CR, Demissie S, Soranzo N, Bianchi EN, Grundberg E, Liang L, Richards JB, Estrada K, Zhou Y, van Nas A, Moffatt MF, Zhai G, Hofman A, van Meurs JB, Pols HA, Price RI, Nilsson O, Pastinen T, Cupples LA, Lusis AJ, Schadt EE, Ferrari S, Uitterlinden AG, Rivadeneira F, Spector TD, Karasik D, Kiel DP. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet. 2010 Jun 10;6(6):e1000977. [PDF File]
Hysi PG, Young TL, Fernandez-Medarde A, Mackey DA, Andrew T, Solouki AM, Hewitt AW, Macgregor S, Vingerling JR, Li Y-J, Ikram MK, Lee YF, Sham PC, Manyes L, Porteros A, Lopes ML, Carbonaro F, Fahy FJ, Martin NG, van Duijn CM, Spector TD, Rahi JS, Santos E, Klaver CCW, Hammond CJ. A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25. Nature Genetics 2010 ct;42(10):902-5 [PDF File]
Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, Wang JJ, Klein R, Klein BE, Breteler MM, Cheung N, Liew G, Mitchell P, Uitterlinden AG, Rivadeneira F, Hofman A, de Jong PT, van Duijn CM, Kao L, Cheng CY, Smith AV, Glazer NL, Lumley T, McKnight B, Psaty BM, Jonasson F, Eiriksdottir G, Aspelund T; Global BPgen Consortium, Harris TB, Launer LJ, Taylor KD, Li X, Iyengar SK, Xi Q, Sivakumaran TA, Mackey DA, Macgregor S, Martin NG, Young TL, Bis JC, Wiggins KL, Heckbert SR, Hammond CJ, Andrew T, Fahy S, Attia J, Holliday EG, Scott RJ, Islam FM, Rotter JI, McAuley AK, Boerwinkle E, Tai ES, Gudnason V, Siscovick DS, Vingerling JR, Wong TY. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. PLoS Genet. 2010 Oct 28;6(10):e1001184 [PDF File]
Illig T, Gieger C, Zhai G, Römisch-Margl W, Wang-Sattler R, Prehn C, Altmaier E, Kastenmüller G, Kato BS, Mewes HW, Meitinger T, de Angelis MH, Kronenberg F, Soranzo N, Wichmann HE, Spector TD, Adamski J, Suhre K. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010 Feb;42(2):137-41 [PDF File]
Jamshidi Y, Nolte IM, Spector TD, Snieder H. Novel genes for QTc interval. How much heritability is explained, and how much is left to find? Genome Med. 2010 May 27;2(5):35. [PDF File]
Kerkhof HJ, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P, Ingvarsson T, Jhamai M, Jonsson H, Stolk L, Thorleifsson G, Zhai G, Zhang F, Zhu Y, van der Breggen R, Carr A, Doherty M, Doherty S, Felson DT, Gonzalez A, Halldorsson BV, Hart DJ, Hauksson VB, Hofman A, Ioannidis JP, Kloppenburg M, Lane NE, Loughlin J, Luyten FP, Nevitt MC, Parimi N, Pols HA, Rivadeneira F, Slagboom EP, Styrkársdóttir U, Tsezou A, van de Putte T, Zmuda J, Spector TD, Stefansson K, Uitterlinden AG, van Meurs JB. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum. 2010 Jan 7;62(2):499-510. [PDF File]
Kerkhof HJ, Meulenbelt I, Carr A, Gonzalez A, Hart D, Hofman A, Kloppenburg M, Lane NE, Loughlin J, Nevitt MC, Pols HA, Rivadeneira F, Slagboom EP, Spector TD, Stolk L, Tsezou A, Uitterlinden AG, Valdes AM, van Meurs JB. Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis. BMC Med Genet. 2010 Nov 16;11:164. [PDF File]
Kung AW, Xiao SM, Cherny S, Li GH, Gao Y, Tso G, Lau KS, Luk KD, Liu JM, Cui B, Zhang MJ, Zhang ZL, He JW, Yue H, Xia WB, Luo LM, He SL, Kiel DP, Karasik D, Hsu YH, Cupples LA, Demissie S, Styrkarsdottir U, Halldorsson BV, Sigurdsson G, Thorsteinsdottir U, Stefansson K, Richards JB, Zhai G, Soranzo N, Valdes A, Spector TD, Sham PC. Association of JAG1 with Bone Mineral Density and Osteoporotic Fractures: A Genome-wide Association Study and Follow-up Replication Studies. Am J Hum Genet. 2010 Feb 12;86(2):229-39.[PDF File]
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segrè AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Vernon Smith A, Mägi R, Pastinen T, Liang L, Heid IM, Luan J, Thorleifsson G, Winkler TW, Goddard ME, Sin Lo K, Palmer C, Workalemahu T, Aulchenko YS, Johansson A, Carola Zillikens M, Feitosa MF, Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I, Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ, Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M, Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF, Wiklund F, Xu J, Hua Zhao J, Nyholt DR, Pellikka N, Perola M, Perry JR, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T, Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon AL, Gibson Q, Grundberg E, Hao K, Juhani Junttila M, Kaplan LM, Kettunen J, König IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon M, McKnight B, Morris AP, Müller M, Suh Ngwa J, Purcell S, Rafelt S, Salem RM, Salvi E, Sanna S, Shi J, Sovio U, Thompson JR, Turchin MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren P, Balmforth AJ, Campbell H, Citterio L, De Grandi A, Dominiczak A, Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJ, Glorioso N, Haiqing S, Hartikainen AL, Havulinna AS, Hicks AA, Hui J, Igl W, Illig T, Jula A, Kajantie E, Kilpeläinen TO, Koiranen M, Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu J, Lokki ML, Marusic A, Maschio A, Meitinger T, Mulas A, Paré G, Parker AN, Peden JF, Petersmann A, Pichler I, Pietiläinen KH, Pouta A, Ridderstråle M, Rotter JI, Sambrook JG, Sanders AR, Oliver Schmidt C, Sinisalo J, Smit JH, Stringham HM, Bragi Walters G, Widen E, Wild SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall M, McArdle WL, Nelis M, Peters MJ, Ripatti S, van Meurs JB, Aben KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S, Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hall AS, Hamsten A, Huikuri HV, Iribarren C, Kähönen M, Kaprio J, Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtimäki T, Melander O, Mosley TH Jr, Musk AW, Nieminen MS, O'Donnell CJ, Ohlsson C, Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD, Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS, Stumvoll M, Tönjes A, Tuomilehto J, van Ommen GJ, Viikari J, Heath AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM, Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Grönberg H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Mark Lathrop G, Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL, Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Adrienne Cupples L, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes RB, Jarvelin MR, Mooser V, Munroe PB, Ouwehand WH, Penninx BW, Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD, Völzke H, Watkins H, Wilson JF, Groop LC, Haritunians T, Hu FB, Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter DJ, O'Connell JR, Strachan DP, Wichmann HE, Borecki IB, van Duijn CM, Schadt EE, Thorsteinsdottir U, Peltonen L, Uitterlinden AG, Visscher PM, Chatterjee N, Loos RJ, Boehnke M, McCarthy MI, Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM, Hirschhorn JN. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010 Oct 14;467(7317):832-8. Epub 2010 Sep 29 [PDF File]
Levy D, Neuhausen SL, Hunt SC, Kimura M, Hwang SJ, Chen W, Bis JC, Fitzpatrick AL, Smith E, Johnson AD, Gardner JP, Srinivasan SR, Schork N, Rotter JI, Herbig U, Psaty BM, Sastrasinh M, Murray SS, Vasan RS, Province MA, Glazer NL, Lu X, Cao X, Kronmal R, Mangino M, Soranzo N, Spector TD, Berenson GS, Aviv A. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9293-8. [PDF File]
Liu F, Wollstein A, Hysi P, Ankra-Badu G, Spector TD, Park D, Zhu G, Larsson M, Duffy D, Montgomery GW, Mackey DA, Walsh S, Lao O, Hofman A, Rivadeneira F, Vingerling JR, Uitterlinden Ag, Martin NG, Hammond CJ, Kayser M. Digital quantification of human eye color highlights genetic association of three new loci. PLoS Genetics 2010 May 6;6(5) [PDF File]
Livshits G, Ermakov S, Popham M, Macgregor AJ, Sambrook PN, Spector TD, Williams FM. Evidence that bone mineral density plays a role in degenerative disc disease: the UK Twin Spine Study. 2010 Dec;69(12):2102-6 [PDF File]
Lu Y, Dimasi DP, Hysi PG, Hewitt AW, Burdon KP, Toh TY, Ruddle JB, Li YJ, Mitchell P, Healey PR, Montgomery GW, Hansell N, Spector TD, Martin NG, Young TL, Hammond CJ, Macgregor S, Craig JE, Mackey DA. Common Genetic Variants near the Brittle Cornea Syndrome Locus ZNF469 Influence the Blinding Disease Risk Factor Central Corneal Thickness. PLoS Genetics 2010 May 13;6(5):e1000947 [PDF File]
Macgregor S, Hewitt AW, Hysi PG, Ruddle JB, Medland SE, Henders AK, Gordon SD, Andrew T, McEvoy B, Sanfilippo PG, Carbonaro F, Tah V, Li YJ, Bennett SL, Craig JE, Montgomery GW, Tran-Viet KN, Brown NL, Spector TD, Martin NG, Young TL, Hammond CJ, Mackey DA. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. Hum Mol Genet. 2010 Jul 1;19(13):2716-24. [PDF File]
Marzi C, Albrecht E, Hysi PG, Lagou V, Waldenberger M, Tönjes A, Prokopenko I, Heim K, Blackburn H, Ried JS, Kleber ME, Mangino M, Thorand B, Peters A, Hammond CJ, Grallert H, Boehm BO, Kovacs P, Geistlinger L, Prokisch H, Winkelmann BR, Spector TD, Wichmann HE, Stumvoll M, Soranzo N, März W, Koenig W, Illig T, Gieger C. Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A. PLoS Genet. 2010 Nov 18;6(11):e1001213. [PDF File]
Njajou OT, Blackburn EH, Pawlikowska L, Mangino M, Damcott CM, Kwok PY, Spector TD, Newman AB, Harris TB, Cummings SR, Cawthon RM, Shuldiner AR, Valdes AM, Hsueh WC. A common variant in the telomerase RNA component is associated with short telomere length. PLoS One. 2010 Sep 27;5(9):e13048 [PDF File]
Noon E, Singh S, Cuzick J, Spector TD, Williams FM, Frost ML, Howell A, Harvie M, Eastell R, Coleman RE, Fogelman I, Blake GM; for the IBIS-II Bone Substudy. Significant differences in UK and US female bone density reference ranges. Osteoporos Int. 2010 Nov;21(11):1871-80. [PDF File]
Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Lee WK, Gentilini D, Hastie CE, Menni C, Monti MC, Delles C, Laing S, Corso B, Navis G, Kwakernaak AJ, van der Harst P, Bochud M, Maillard M, Burnier M, Hedner T, Kjeldsen S, Wahlstrand B, Sjögren M, Fava C, Montagnana M, Danese E, Torffvit O, Hedblad B, Snieder H, Connell JM, Brown M, Samani NJ, Farrall M, Cesana G, Mancia G, Signorini S, Grassi G, Eyheramendy S, Wichmann HE, Laan M, Strachan DP, Sever P, Shields DC, Stanton A, Vollenweider P, Teumer A, Völzke H, Rettig R, Newton-Cheh C, Arora P, Zhang F, Soranzo N, Spector TD, Lucas G, Kathiresan S, Siscovick DS, Luan J, Loos RJ, Wareham NJ, Penninx BW, Nolte IM, McBride M, Miller WH, Nicklin SA, Baker AH, Graham D, McDonald RA, Pell JP, Sattar N, Welsh P; Global BPgen Consortium, Munroe P, Caulfield MJ, Zanchetti A, Dominiczak AF. Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet. 2010 Oct 28;6(10):e1001177 [PDF File]
Panicker V, Wilson SG, Walsh JP, Richards JB, Brown SJ, Beilby JP, Bremner AP, Surdulescu GL, Qweitin E, Gillham-Nasenya I, Soranzo N, Lim EM, Fletcher SJ, Spector TD. A locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study. Am J Hum Genet. 2010 Sep 10;87(3):430-5 [PDF File]
Rakyan VK, Down TA, Maslau S, Andrew T, Yang TP, Beyan H, Whittaker P, McCann OT, Finer S, Valdes AM, Leslie RD, Deloukas P, Spector TD. Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res. 2010 Apr;20(4):434-9 [PDF File]
Ramdas WD, van Koolwijk LME, Ikram MK, Jansonius NM, de Jong PTVM, Bergen AAB, Isaacs A, Amin N, Aulchenko YS, Wolfs RCW, Hofman A, Rivadeneira F, Oostra BA, Uitterlinden AG, Hysi P, Hammond CJ, Lemij HJ, Vingerling JR, Klaver CCW, van Duijn CM. A genome-wide association study of optic disc parameters. PLoS Genetics 2010 Jun 10;6(6):e1000978. [PDF File]
Shane S, Nicolaou N, Cherkas L, Spector TD. Genetics, the Big Five, and the tendency to be self-employed. J Appl Psychol. 2010 Nov;95(6):1154-62
Smith NL, Chen MH, Dehghan A, Strachan DP, Basu S, Soranzo N, Hayward C, Rudan I, Sabater-Lleal M, Bis JC, de Maat MP, Rumley A, Kong X, Yang Q, Williams FM, Vitart V, Campbell H, Mälarstig A, Wiggins KL, Van Duijn CM, McArdle WL, Pankow JS, Johnson AD, Silveira A, McKnight B, Uitterlinden AG; Wellcome Trust Case Control Consortium, Aleksic N, Meigs JB, Peters A, Koenig W, Cushman M, Kathiresan S, Rotter JI, Bovill EG, Hofman A, Boerwinkle E, Tofler GH, Peden JF, Psaty BM, Leebeek F, Folsom AR, Larson MG, Spector TD, Wright AF, Wilson JF, Hamsten A, Lumley T, Witteman JC, Tang W, O'Donnell CJ. Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor. The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation. 2010 15 Mar 30;121(12):1382-92 [PDF File]
Solouki AM, Verhoeven VJM, van Duijn CM, Verkerk AJMH, Ikram MK, Hysi PG, Despriet DDG, van Koolwijk LM, Ho L, Ramdas W, Czudowska M, Amin N, Struchalin M, Aulchenko YS, van Rij G, Isaacs A, Kuijpers RWAM, Young TL, Mackey DA, Spector TD, Swagemakers SMA, van Oosterhout AALJ, Oostra BA, Rivadeneira F, Uitterlinden AG, Hofman A, de Jong PTVM, Hammond CJ, Vingerling JR, Klaver CCW. A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. Nature Genetics 2010 Oct;42(10):897-901. [PDF File]
Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS, Heeney MM, Devaney JM, Reilly MP, Ricketts SL, Stewart AF, Voight BF, Willenborg C, Wright B, Altshuler D, Arking D, Balkau B, Barnes D, Boerwinkle E, Böhm B, Bonnefond A, Bonnycastle LL, Boomsma DI, Bornstein SR, Böttcher Y, Bumpstead S, Burnett-Miller MS, Campbell H, Cao A, Chambers J, Clark R, Collins FS, Coresh J, de Geus EJ, Dei M, Deloukas P, Döring A, Egan JM, Elosua R, Ferrucci L, Forouhi N, Fox CS, Franklin C, Franzosi MG, Gallina S, Goel A, Graessler J, Grallert H, Greinacher A, Hadley D, Hall A, Hamsten A; on behalf of Procardis Consortium, Hayward C, Heath S, Herder C, Homuth G, Hottenga JJ, Hunter-Merrill R, Illig T, Jackson AU, Jula A, Kleber M, Knouff CW, Kong A, Kooner J, Köttgen A, Kovacs P, Krohn K, Kühnel B, Kuusisto J, Laakso M, Lathrop M, Lecoeur C, Li M, Li M, Loos RJ, Luan J, Lyssenko V, Mägi R, Magnusson PK, Mälarstig A, Mangino M, Martínez-Larrad MT, März W, McArdle WL, McPherson R, Meisinger C, Meitinger T, Melander O, Mohlke KL, Mooser VE, Morken MA, Narisu N, Nathan DM, Nauck M, O'Donnell C, Oexle K, Olla N, Pankow JS, Payne F, Peden JF, Pedersen NL, Peltonen L, Perola M, Polasek O, Porcu E, Rader DJ, Rathmann W, Ripatti S, Rocheleau G, Roden M, Rudan I, Salomaa V, Saxena R, Schlessinger D, Schunkert H, Schwarz P, Seedorf U, Selvin E, Serrano-Ríos M, Shrader P, Silveira A, Siscovick D, Song K, Spector TD, Stefansson K, Steinthorsdottir V, Strachan DP, Strawbridge R, Stumvoll M, Surakka I, Swift AJ, Tanaka T, Teumer A, Thorleifsson G, Thorsteinsdottir U, Tönjes A, Usala G, Vitart V, Völzke H, Wallaschofski H, Waterworth DM, Watkins H, Wichmann HE, Wild SH, Willemsen G, Williams GH, Wilson JF, Winkelmann J, Wright AF; WTCCC, Zabena C, Zhao JH, Epstein SE, Erdmann J, Hakonarson HH, Kathiresan S, Khaw KT, Roberts R, Samani NJ, Fleming MD, Sladek R, Abecasis G, Boehnke M, Froguel P, Groop L, McCarthy MI, Kao WH, Florez JC, Uda M, Wareham NJ, Barroso I, Meigs JB. Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways. Diabetes. 2010 Dec;59(12):3229-39. [PDF File]
Sotoodehnia N, Isaacs A, de Bakker PI, Dörr M, Newton-Cheh C, Nolte IM, van der Harst P, Müller M, Eijgelsheim M, Alonso A, Hicks AA, Padmanabhan S, Hayward C, Smith AV, Polasek O, Giovannone S, Fu J, Magnani JW, Marciante KD, Pfeufer A, Gharib SA, Teumer A, Li M, Bis JC, Rivadeneira F, Aspelund T, Köttgen A, Johnson T, Rice K, Sie MP, Wang YA, Klopp N, Fuchsberger C, Wild SH, Mateo Leach I, Estrada K, Völker U, Wright AF, Asselbergs FW, Qu J, Chakravarti A, Sinner MF, Kors JA, Petersmann A, Harris TB, Soliman EZ, Munroe PB, Psaty BM, Oostra BA, Cupples LA, Perz S, de Boer RA, Uitterlinden AG, Völzke H, Spector TD, Liu FY, Boerwinkle E, Dominiczak AF, Rotter JI, van Herpen G, Levy D, Wichmann HE, van Gilst WH, Witteman JC, Kroemer HK, Kao WH, Heckbert SR, Meitinger T, Hofman A, Campbell H, Folsom AR, van Veldhuisen DJ, Schwienbacher C, O'Donnell CJ, Volpato CB, Caulfield MJ, Connell JM, Launer L, Lu X, Franke L, Fehrmann RS, te Meerman G, Groen HJ, Weersma RK, van den Berg LH, Wijmenga C, Ophoff RA, Navis G, Rudan I, Snieder H, Wilson JF, Pramstaller PP, Siscovick DS, Wang TJ, Gudnason V, van Duijn CM, Felix SB, Fishman GI, Jamshidi Y, Stricker BH, Samani NJ, Kääb S, Arking DE. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet. 2010 Dec;42(12):1068-76 [PDF File]
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ, Segrè AV, Estrada K, Liang L, Nemesh J, Park JH, Gustafsson S, Kilpeläinen TO, Yang J, Bouatia-Naji N, Esko T, Feitosa MF, Kutalik Z, Mangino M, Raychaudhuri S, Scherag A, Smith AV, Welch R, Zhao JH, Aben KK, Absher DM, Amin N, Dixon AL, Fisher E, Glazer NL, Goddard ME, Heard-Costa NL, Hoesel V, Hottenga JJ, Johansson A, Johnson T, Ketkar S, Lamina C, Li S, Moffatt MF, Myers RH, Narisu N, Perry JR, Peters MJ, Preuss M, Ripatti S, Rivadeneira F, Sandholt C, Scott LJ, Timpson NJ, Tyrer JP, van Wingerden S, Watanabe RM, White CC, Wiklund F, Barlassina C, Chasman DI, Cooper MN, Jansson JO, Lawrence RW, Pellikka N, Prokopenko I, Shi J, Thiering E, Alavere H, Alibrandi MT, Almgren P, Arnold AM, Aspelund T, Atwood LD, Balkau B, Balmforth AJ, Bennett AJ, Ben-Shlomo Y, Bergman RN, Bergmann S, Biebermann H, Blakemore AI, Boes T, Bonnycastle LL, Bornstein SR, Brown MJ, Buchanan TA, Busonero F, Campbell H, Cappuccio FP, Cavalcanti-Proença C, Chen YD, Chen CM, Chines PS, Clarke R, Coin L, Connell J, Day IN, Heijer MD, Duan J, Ebrahim S, Elliott P, Elosua R, Eiriksdottir G, Erdos MR, Eriksson JG, Facheris MF, Felix SB, Fischer-Posovszky P, Folsom AR, Friedrich N, Freimer NB, Fu M, Gaget S, Gejman PV, Geus EJ, Gieger C, Gjesing AP, Goel A, Goyette P, Grallert H, Gräßler J, Greenawalt DM, Groves CJ, Gudnason V, Guiducci C, Hartikainen AL, Hassanali N, Hall AS, Havulinna AS, Hayward C, Heath AC, Hengstenberg C, Hicks AA, Hinney A, Hofman A, Homuth G, Hui J, Igl W, Iribarren C, Isomaa B, Jacobs KB, Jarick I, Jewell E, John U, Jørgensen T, Jousilahti P, Jula A, Kaakinen M, Kajantie E, Kaplan LM, Kathiresan S, Kettunen J, Kinnunen L, Knowles JW, Kolcic I, König IR, Koskinen S, Kovacs P, Kuusisto J, Kraft P, Kvaløy K, Laitinen J, Lantieri O, Lanzani C, Launer LJ, Lecoeur C, Lehtimäki T, Lettre G, Liu J, Lokki ML, Lorentzon M, Luben RN, Ludwig B; MAGIC, Manunta P, Marek D, Marre M, Martin NG, McArdle WL, McCarthy A, McKnight B, Meitinger T, Melander O, Meyre D, Midthjell K, Montgomery GW, Morken MA, Morris AP, Mulic R, Ngwa JS, Nelis M, Neville MJ, Nyholt DR, O'Donnell CJ, O'Rahilly S, Ong KK, Oostra B, Paré G, Parker AN, Perola M, Pichler I, Pietiläinen KH, Platou CG, Polasek O, Pouta A, Rafelt S, Raitakari O, Rayner NW, Ridderstråle M, Rief W, Ruokonen A, Robertson NR, Rzehak P, Salomaa V, Sanders AR, Sandhu MS, Sanna S, Saramies J, Savolainen MJ, Scherag S, Schipf S, Schreiber S, Schunkert H, Silander K, Sinisalo J, Siscovick DS, Smit JH, Soranzo N, Sovio U, Stephens J, Surakka I, Swift AJ, Tammesoo ML, Tardif JC, Teder-Laving M, Teslovich TM, Thompson JR, Thomson B, Tönjes A, Tuomi T, van Meurs JB, van Ommen GJ, Vatin V, Viikari J, Visvikis-Siest S, Vitart V, Vogel CI, Voight BF, Waite LL, Wallaschofski H, Walters GB, Widen E, Wiegand S, Wild SH, Willemsen G, Witte DR, Witteman JC, Xu J, Zhang Q, Zgaga L, Ziegler A, Zitting P, Beilby JP, Farooqi IS, Hebebrand J, Huikuri HV, James AL, Kähönen M, Levinson DF, Macciardi F, Nieminen MS, Ohlsson C, Palmer LJ, Ridker PM, Stumvoll M, Beckmann JS, Boeing H, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ, Collins FS, Cupples LA, Smith GD, Erdmann J, Froguel P, Grönberg H, Gyllensten U, Hall P, Hansen T, Harris TB, Hattersley AT, Hayes RB, Heinrich J, Hu FB, Hveem K, Illig T, Jarvelin MR, Kaprio J, Karpe F, Khaw KT, Kiemeney LA, Krude H, Laakso M, Lawlor DA, Metspalu A, Munroe PB, Ouwehand WH, Pedersen O, Penninx BW, Peters A, Pramstaller PP, Quertermous T, Reinehr T, Rissanen A, Rudan I, Samani NJ, Schwarz PE, Shuldiner AR, Spector TD, Tuomilehto J, Uda M, Uitterlinden A, Valle TT, Wabitsch M, Waeber G, Wareham NJ, Watkins H; on behalf of Procardis Consortium, Wilson JF, Wright AF, Zillikens MC, Chatterjee N, McCarroll SA, Purcell S, Schadt EE, Visscher PM, Assimes TL, Borecki IB, Deloukas P, Fox CS, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, Mohlke KL, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, van Duijn CM, Wichmann HE, Frayling TM, Thorsteinsdottir U, Abecasis GR, Barroso I, Boehnke M, Stefansson K, North KE, I McCarthy M, Hirschhorn JN, Ingelsson E, Loos RJ. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010 Nov;42(11):937-948. Epub 2010 Oct 10 [PDF File]
Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K, Johnson T, Caulfield M, Munroe P; Global Blood Pressure Genetics Consortium, Umemura S, Ueshima H, Miki T. Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project. Hypertension. 2010 Nov;56(5):973-80 [PDF File]
Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Aulchenko YS, Thorleifsson G, Feitosa MF, Chambers J, Orho-Melander M, Melander O, Johnson T, Li X, Guo X, Li M, Shin Cho Y, Jin Go M, Jin Kim Y, Lee JY, Park T, Kim K, Sim X, Twee-Hee Ong R, Croteau-Chonka DC, Lange LA, Smith JD, Song K, Hua Zhao J, Yuan X, Luan J, Lamina C, Ziegler A, Zhang W, Zee RY, Wright AF, Witteman JC, Wilson JF, Willemsen G, Wichmann HE, Whitfield JB, Waterworth DM, Wareham NJ, Waeber G, Vollenweider P, Voight BF, Vitart V, Uitterlinden AG, Uda M, Tuomilehto J, Thompson JR, Tanaka T, Surakka I, Stringham HM, Spector TD, Soranzo N, Smit JH, Sinisalo J, Silander K, Sijbrands EJ, Scuteri A, Scott J, Schlessinger D, Sanna S, Salomaa V, Saharinen J, Sabatti C, Ruokonen A, Rudan I, Rose LM, Roberts R, Rieder M, Psaty BM, Pramstaller PP, Pichler I, Perola M, Penninx BW, Pedersen NL, Pattaro C, Parker AN, Pare G, Oostra BA, O'Donnell CJ, Nieminen MS, Nickerson DA, Montgomery GW, Meitinger T, McPherson R, McCarthy MI, McArdle W, Masson D, Martin NG, Marroni F, Mangino M, Magnusson PK, Lucas G, Luben R, Loos RJ, Lokki ML, Lettre G, Langenberg C, Launer LJ, Lakatta EG, Laaksonen R, Kyvik KO, Kronenberg F, König IR, Khaw KT, Kaprio J, Kaplan LM, Johansson A, Jarvelin MR, Cecile J W Janssens A, Ingelsson E, Igl W, Kees Hovingh G, Hottenga JJ, Hofman A, Hicks AA, Hengstenberg C, Heid IM, Hayward C, Havulinna AS, Hastie ND, Harris TB, Haritunians T, Hall AS, Gyllensten U, Guiducci C, Groop LC, Gonzalez E, Gieger C, Freimer NB, Ferrucci L, Erdmann J, Elliott P, Ejebe KG, Döring A, Dominiczak AF, Demissie S, Deloukas P, de Geus EJ, de Faire U, Crawford G, Collins FS, Chen YD, Caulfield MJ, Campbell H, Burtt NP, Bonnycastle LL, Boomsma DI, Boekholdt SM, Bergman RN, Barroso I, Bandinelli S, Ballantyne CM, Assimes TL, Quertermous T, Altshuler D, Seielstad M, Wong TY, Tai ES, Feranil AB, Kuzawa CW, Adair LS, Taylor HA Jr, Borecki IB, Gabriel SB, Wilson JG, Holm H, Thorsteinsdottir U, Gudnason V, Krauss RM, Mohlke KL, Ordovas JM, Munroe PB, Kooner JS, Tall AR, Hegele RA, Kastelein JJ, Schadt EE, Rotter JI, Boerwinkle E, Strachan DP, Mooser V, Stefansson K, Reilly MP, Samani NJ, Schunkert H, Cupples LA, Sandhu MS, Ridker PM, Rader DJ, van Duijn CM, Peltonen L, Abecasis GR, Boehnke M, Kathiresan S. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 Aug 5;466(7307):703-4 [PDF File]
Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F, Sulem P, Rafnar T, Esko T, Walter S, Gieger C, Rawal R, Mangino M, Prokopenko I, Mägi R, Keskitalo K, Gudjonsdottir IH, Gretarsdottir S, Stefansson H, Thompson JR, Aulchenko YS, Nelis M, Aben KK, den Heijer M, Dirksen A, Ashraf H, Soranzo N, Valdes AM, Steves C, Uitterlinden AG, Hofman A, Tönjes A, Kovacs P, Hottenga JJ, Willemsen G, Vogelzangs N, Döring A, Dahmen N, Nitz B, Pergadia ML, Saez B, De Diego V, Lezcano V, Garcia-Prats MD, Ripatti S, Perola M, Kettunen J, Hartikainen AL, Pouta A, Laitinen J, Isohanni M, Huei-Yi S, Allen M, Krestyaninova M, Hall AS, Jones GT, van Rij AM, Mueller T, Dieplinger B, Haltmayer M, Jonsson S, Matthiasson SE, Oskarsson H, Tyrfingsson T, Kiemeney LA, Mayordomo JI, Lindholt JS, Pedersen JH, Franklin WA, Wolf H, Montgomery GW, Heath AC, Martin NG, Madden PA, Giegling I, Rujescu D, Järvelin MR, Salomaa V, Stumvoll M, Spector TD, Wichmann HE, Metspalu A, Samani NJ, Penninx BW, Oostra BA, Boomsma DI, Tiemeier H, van Duijn CM, Kaprio J, Gulcher JR; The ENGAGE Consortium, McCarthy MI, Peltonen L, Thorsteinsdottir U, Stefansson K. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet.2010 May;42(5):448-53. [PDF File]
Thorleifsson G, Walters GB, Hewitt AW, Masson G, Helgason A, DeWan A, Sigurdsson A, Jonasdottir A, Gudjonsson SA, Kristinn P. Magnusson KP, Stefansson H, Lam DSC, Tam POS, Gudmundsdottir GJ, Southgate L, Burdon KP, Gottfredsdottir MS, Aldred MA, Mitchell P, St Clair D, Collier DA, Tang N, Sveinsson O, Macgregor S, Martin NG, Cree AJ, Gibson J, MacLeod A, Jacob A, Ennis S, Young TL, Chan JCN, Karwatowski WSS, Hammond CJ, Thordarson K, Zhang M, Wadelius C, Lotery AJ, Trembath RC, Pang CP, Hoh J, Craig JE, Kong A, Mackey DA, Jonasson F, Thorsteinsdottir U, Stefansson K. Common variants near CAV1 and CAV2 are associated with primary open angle glaucoma. Nature Genetics 2010 Oct;42(10):906-9. [PDF File]
Valdes AM, Arden NK, Tamm A, Kisand K, Doherty S, Pola E, Cooper C, Tamm A, Muir K, Kerna I, Hart D, O'Neil F, Zhang W, Spector TD, Maciewicz RA, Doherty M. A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis. Osteoarthritis Cartilage. 2010 May;18(5):699-704 [PDF File]
Valdes AM, Arden NK, Vaughn FL, Doherty SA, Leaverton PE, Zhang W, Muir KR, Rampersaud E, Dennison EM, Edwards MH, Jameson KA, Javaid MK, Spector TD, Cooper C, Maciewicz RA, Doherty M. Role of the Na(V)1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain. Arthritis Care Res (Hoboken). 2010 Oct 28. [PDF File]
Valdes AM, Deary IJ, Gardner J, Kimura M, Lu X, Spector TD, Aviv A, Cherkas LF. Leukocyte telomere length is associated with cognitive performance in healthy women. Neurobiol Aging. 2010 Jun;31(6):986-92. [PDF File]
Valdes AM, Spector TD. The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol. 2010 Mar;22(2):139-43
Valdes AM, Spector TD. The clinical relevance of genetic susceptibility to osteoarthritis. Best Practice & Research Clinical Rheumatology. 2010 Feb;24(1):3-14 [PDF File]
Valdes AM, Spector TD, Tamm A, Kisand K, Doherty SA, Dennison EM, Mangino M, Tamm A, Kerna I, Hart DJ, Wheeler M, Cooper C, Lories RJ, Arden NK, Doherty M. Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis Rheum. 2010 Aug;62(8):2347-52 [PDF File]
Veselka L, Petrides KV, Schermer JA, Cherkas LF, Spector TD, Vernon PA. Phenotypic and Genetic Relations Between the HEXACO Dimensions and Trait Emotional Intelligence. Twin Res Hum Genet. 2010 Feb;13(1):66-71.
Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, Peltonen L, Cooper JD, O'Reilly PF, Houston DK, Glazer NL, Vandenput L, Peacock M, Shi J, Rivadeneira F, McCarthy MI, Anneli P, de Boer IH, Mangino M, Kato B, Smyth DJ, Booth SL, Jacques PF, Burke GL, Goodarzi M, Cheung CL, Wolf M, Rice K, Goltzman D, Hidiroglou N, Ladouceur M, Wareham NJ, Hocking LJ, Hart D, Arden NK, Cooper C, Malik S, Fraser WD, Hartikainen AL, Zhai G, Macdonald HM, Forouhi NG, Loos RJ, Reid DM, Hakim A, Dennison E, Liu Y, Power C, Stevens HE, Jaana L, Vasan RS, Soranzo N, Bojunga J, Psaty BM, Lorentzon M, Foroud T, Harris TB, Hofman A, Jansson JO, Cauley JA, Uitterlinden AG, Gibson Q, Järvelin MR, Karasik D, Siscovick DS, Econs MJ, Kritchevsky SB, Florez JC, Todd JA, Dupuis J, Hyppönen E, Spector TD. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010 Jul 17;376(9736):180-8 [PDF File]
Williams FM, Popham M, Livshits G, Sambrook PN, Spector TD, Macgregor AJ. A response to Videman et al., Challenging the cumulative injury model: positive effects of greater body mass on disc degeneration. Spine J. 2010 Jun;10(6):571-2. [PDF File]
Williams FM, Skinner J, Spector TD, Cassidy A, Clark IM, Davidson RM, Macgregor AJ. Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action. BMC Musculoskelet Disord. 2010 Dec 8;11:280. [PDF File]
Williams FMK, Spector TD, MacGregor AJ. Pain reporting at different body sites is explained by a single underlying genetic factor. Rheumatology (Oxford) 2010 Sep;49(9):1753-5 [PDF File]
Zhai G, Wang-Sattler R, Hart DJ, Arden NK, Hakim AJ, Illig T, Spector TD. Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis. Ann Rheum Dis. 2010 Jun;69(6):1227-31 [PDF File]
2009
Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T, Martin NG, Pedersen NL, Kyvik KO, Kaprio J, Hofman A, Freimer NB, Jarvelin MR, Gyllensten U, Campbell H, Rudan I, Johansson A, Marroni F, Hayward C, Vitart V, Jonasson I, Pattaro C, Wright A, Hastie N, Pichler I, Hicks AA, Falchi M, Willemsen G, Hottenga JJ, de Geus EJ, Montgomery GW, Whitfield J, Magnusson P, Saharinen J, Perola M, Silander K, Isaacs A, Sijbrands EJ, Uitterlinden AG, Witteman JC, Oostra BA, Elliott P, Ruokonen A, Sabatti C, Gieger C, Meitinger T, Kronenberg F, Döring A, Wichmann HE, Smit JH, McCarthy MI, van Duijn CM, Peltonen L; for the ENGAGE Consortium. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet. 2009 Jan;41 (1):47-55 [PDF File]
Burri AV, Cherkas LM, Spector TD. The Genetics and Epidemiology of Female Sexual Dysfunction: A Review. J Sex Med. 2009; 6:646-657 [PDF File]
Burri AV, Cherkas LM, Spector TD. Emotional intelligence and its association with orgasmic frequency in women. Journal of Sexual Medicine 2009 Jul;6(7):1930-7 [PDF File]
Carbonaro F, Andrew T, Mackey D, Young TL, Spector T, Hammond CJ. Repeated measures of intraocular pressure result in a higher heritability and greater power in genetic linkage studies. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5115-9. [PDF File]
Cassidy A, Skidmore P, Rimm EB, Welch A, Fairweather-Tait S, Skinner J, Burling K, Richards JB, Spector TD, MacGregor AJ. Plasma adiponectin concentrations are associated with body composition and plant-based dietary factors in female twins. J Nutr. 2009 Feb;139(2):353-8 [PDF File]
Cecelja M, Jiang B, McNeill K, Kato B, Ritter J, Spector T, Chowienczyk P. Increased wave reflection rather than central arterial stiffness is the main determinant of raised pulse pressure in women and relates to mismatch in arterial dimensions: a twin study. J Am Coll Cardiol. 2009 Aug 18;54(8):695-703.[PDF File]
Colebatch AN, Hart DJ, Zhai G, Williams FM, Spector TD, Arden NK. Effective measurement of knee alignment using AP knee radiographs. Knee. 2009 Jan;16(1):42-45 [PDF File]
Creary LE, McKenzie CA, Menzel S, Hanchard NA, Taylor V, Hambleton I, Spector TD, Forrester TE, Thein SL. Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic loci controlling fetal haemoglobin. Br J Haematol. 2009 Mar; 144(6):954-60 [PDF File]
DeBruine LM, Smith FG, Jones BC, Roberts SC, Petrie M, Spector TD. Kin recognition signals in adult faces. Vision Res. 2009 Jan;49(1):38-43 [PDF File]
Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gómez-Reino JJ, Gonzalez A, Halldorsson BV, Hauksson VB, Hofman A, Hart DJ, Ikegawa S, Ingvarsson T, Jiang Q, Jonsdottir I, Jonsson H, Kerkhof HJ, Kloppenburg M, Lane NE, Li J, Lories RJ, van Meurs JB, Näkki A, Nevitt MC, Rodriguez-Lopez J, Shi D, Slagboom PE, Stefansson K, Tsezou A, Wallis GA, Watson CM, Spector TD, Uitterlinden AG, Valdes AM, Ioannidis JP. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum. 2009 May 28;60(6):1710-1721 [PDF File]
Falchi M, Bataille V, Hayward NK, Duffy DL, Newton Bishop JA, Pastinen T, Cervino A, Zhao ZZ, Deloukas P, Soranzo N, Elder DE, Barrett JH, Martin NG, Bishop TD, Montgomery GW, Spector TD. Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi. Nature Genetics 2009 Aug;41(8):915-9 [PDF File]
Ganesh SK, Zakai NA, van Rooij FJ, Soranzo N, Smith AV, Nalls MA, Chen MH, Kottgen A, Glazer NL, Dehghan A, Kuhnel B, Aspelund T, Yang Q, Tanaka T, Jaffe A, Bis JC, Verwoert GC, Teumer A, Fox CS, Guralnik JM, Ehret GB, Rice K, Felix JF, Rendon A, Eiriksdottir G, Levy D, Patel KV, Boerwinkle E, Rotter JI, Hofman A, Sambrook JG, Hernandez DG, Zheng G, Bandinelli S, Singleton AB, Coresh J, Lumley T, Uitterlinden AG, Vangils JM, Launer LJ, Cupples LA, Oostra BA, Zwaginga JJ, Ouwehand WH, Thein SL, Meisinger C, Deloukas P, Nauck M, Spector TD, Gieger C, Gudnason V, van Duijn CM, Psaty BM, Ferrucci L, Chakravarti A, Greinacher A, O'Donnell CJ, Witteman JC, Furth S, Cushman M, Harris TB, Lin JP. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet. 2009 Nov;41(11):1191-8. Epub 2009 Oct 11. [PDF File]
Glass D, Lens M, Swaminathan R, Spector TD, Bataille V. Pigmentation and vitamin D metabolism in Caucasians: low vitamin D serum levels in fair skin types in the UK. PLoS One. 2009 Aug 3;4(8):e6477. [PDF File]
Jun G, Guo H, Klein BE, Klein R, Wang JJ, Mitchell P, Miao H, Lee KE, Joshi T, Buck M, Chugha P, Bardenstein D, Klein AP, Bailey-Wilson JE, Gong X, Spector TD, Andrew T, Hammond CJ, Elston RC, Iyengar SK, Wang B. EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet. 2009 Jul;5(7):e1000584. Epub 2009 Jul 31. [PDF File]
Iervolino AC, Perroud N, Fullana MA, Guipponi M, Cherkas L, Collier DA, Mataix-Cols D. Prevalence and heritability of compulsive hoarding: a twin study. Am J Psychiatry. 2009 Oct;166(10):1156-61. Epub 2009 Aug 17. [PDF File]
Illig T, Gieger C, Zhai G, Römisch-Margl W, Wang-Sattler R, Prehn C, Altmaier E, Kastenmüller G, Kato BS, Mewes HW, Meitinger T, de Angelis MH, Kronenberg F, Soranzo N, Wichmann HE, Spector TD, Adamski J, Suhre K. A genome-wide perspective of genetic variation in human metabolism. Nat Genet 2010 Feb;42(2):137-41 [PDF File]
Kettunen J, Perola M, Martin NG, Cornes BK, Wilson SG, Montgomery GW, Benyamin B, Harris JR, Boomsma D, Willemsen G, Hottenga JJ, Slagboom PE, Christensen K, Kyvik KO, Sørensen TI, Pedersen NL, Magnusson PK, Andrew T, Spector TD, Widen E, Silventoinen K, Kaprio J, Palotie A, Peltonen L. Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci. Int J Obes (Lond). 2009 Nov;33(11):1235-42 [PDF File]
Khoo BC, Wilson SG, Worth GK, Perks U, Qweitin E, Spector TD, Price RI. A comparative study between corresponding structural geometric variables using 2 commonly implemented hip structural analysis algorithms applied to dual-energy x-ray absorptiometry images. J Clin Densitom. 2009 Oct-Dec;12(4):461-7.
Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, Johansson A, Nyholt DR, Aulchenko Y, Beckmann JS, Bergmann S, Bochud M, Brown M, Campbell H; EUROSPAN Consortium, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy MI; ENGAGE Consortium, Meitinger T, Mooser V, Munroe P, Nauck M, Peden J, Prokisch H, Salo P, Salomaa V, Samani NJ, Schlessinger D, Uda M, Völker U, Waeber G, Waterworth D, Wang-Sattler R, Wright AF, Adamski J, Whitfield JB, Gyllensten U, Wilson JF, Rudan I, Pramstaller P, Watkins H; PROCARDIS Consortium, Doering A, Wichmann HE; KORA Study, Spector TD, Peltonen L, Völzke H, Nagaraja R, Vollenweider P, Caulfield M; WTCCC, Illig T, Gieger C. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 2009 Jun;5(6):e1000504 [PDF File]
Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan J, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC, Zhao JH, Almgren P, Bandinelli S, Bennett AJ, Bergman RN, Bonnycastle LL, Bumpstead SJ, Chanock SJ, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney AS, Ebrahim S, Elliott P, Erdos MR, Estrada K, Ferrucci L, Fischer G, Forouhi NG, Gieger C, Grallert H, Groves CJ, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna AS, Hofman A, Holle R, Holloway JW, Illig T, Isomaa B, Jacobs LC, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop GM, Lawlor DA, Mangino M, McArdle WL, Meitinger T, Morken MA, Morris AP, Munroe P, Narisu N, Nordström A, Nordström P, Oostra BA, Palmer CN, Payne F, Peden JF, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu MS, Scott LJ, Scuteri A, Silander K, Song K, Yuan X, Stringham HM, Swift AJ, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters GB, Weedon MN; Wellcome Trust Case Control Consortium, Witteman JC, Zhang C, Zhang W, Caulfield MJ, Collins FS, Davey Smith G, Day IN, Franks PW, Hattersley AT, Hu FB, Jarvelin MR, Kong A, Kooner JS, Laakso M, Lakatta E, Mooser V, Morris AD, Peltonen L, Samani NJ, Spector TD, Strachan DP, Tanaka T, Tuomilehto J, Uitterlinden AG, van Duijn CM, Wareham NJ, Hugh Watkins; Procardis Consortia, Waterworth DM, Boehnke M, Deloukas P, Groop L, Hunter DJ, Thorsteinsdottir U, Schlessinger D, Wichmann HE, Frayling TM, Abecasis GR, Hirschhorn JN, Loos RJ, Stefansson K, Mohlke KL, Barroso I, McCarthy MI; Giant Consortium. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet. 2009 Jun;5(6):e1000508. [PDF File]
Liu GF, Riese H, Spector TD, Mangino M, O'Dell SD, Stolk RP, Snieder H. Bivariate genetic modelling of the response to an oral glucose tolerance challenge: A gene x environment interaction approach. Diabetologia. 2009 Jun;52(6):1048-55 [PDF File]
Livshits G, Zhai G, Hart DJ, Kato BS, Wang H, Williams FM, Spector TD. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study. Arthritis Rheum. 2009 Jun 29;60(7):2037-2045 [PDF File]
Lopes MC, Andrew T, Carbonaro F, Spector T, Hammond CJ. Estimating heritability and shared environmental effects for refractive error in twin and family studies.Invest Ophthalmol Vis Sci. 2009 Jan;50(1):126-31. [PDF File]
Macgregor AJ, Li Q, Spector TD, Williams FM. The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee. Rheumatology (Oxford). 2009 Mar;48(3):277-80 [PDF File]
Mackey DA, Mackinnon JR, Brown SA, Kearns LS, Ruddle JB, Sanfilippo PG, Sun C, Hammond CJ, Young TL, Martin NG, Hewitt AW. Twins Eye Study in Tasmania (TEST): Rationale and Methodology to Recruit and Examine Twins. Twin Res Hum Genet. 2009 Oct;12(5):441-54. [PDF File]
Makovey J, Chen JS, Hayward C, Williams FMK, Sambrook PN. Association between serum cholesterol and bone mineral density. Bone 2009; 44:208-213 [PDF File]
Mangino M, Richards BJ, Soranzo N, Zhai G, Aviv A, Valdes AM, Samani NJ, Deloukas P, Spector TD. A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length. J Med Genet. 2009 Jul;46(7):451-4. [PDF File]
McEvoy BP, Montgomery GW, McRae AF, Ripatti S, Perola M, Spector TD, Cherkas L, Ahmadi KR, Boomsma D, Willemsen G, Hottenga JJ, Peterson NL, Magnusson PK, Ohm Kyvik K, Christensen K, Kaprio J, Heikkila K, Palotie A, Widen E, Muilu J, Syvanen AC, Liljedahl U, Hardiman O, Cronin S, Peltonen L, Martin NG, Visscher PM. Geographical structure and differential natural selection amongst North European populations. Genome Res. 2009 May;19(5):804-14 [PDF File]
Mullin BH, Prince RL, Mamotte C, Spector TD, Hart DJ, Dudbridge F, Wilson SG. Further genetic evidence suggesting a role for the RhoGTPase-RhoGEF pathway in osteoporosis. Bone. 2009 Aug;45(2):387-91. [PDF File]
Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KL, Hunt P, Ge D, Heinzen EL, Maia JM, Shianna KV, Weale ME, Cherkas LF, Clement G, Spector TD, Gibson G, Goldstein DB. A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery. Hum Mol Genet. 2009 Dec 1;18(23):4650-61. [PDF File]
Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL; Wellcome Trust Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Döring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst WH, Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syvänen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dörr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Völker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, Völzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan DP, Laan M, Meneton P, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 2009 Jun; 41(6):666-76. [PDF File]
Nicolau N, Shane S, Cherkas L, Spector TD. Opportunity recognition and the tendency to be an entrepreneur: a bivariate genetics perspective. Org Behav & Hum Dec Proc 2009; 108-117 [PDF File]
Nolte IM, Wallace C, Newhouse SJ, Waggott D, Fu J, Soranzo N, Gwilliam R, Deloukas P, Savelieva I, Zheng D, Dalageorgou C, Farrall M, Samani NJ, Connell J, Brown M, Dominiczak A, Lathrop M, Zeggini E, Wain LV; Wellcome Trust Case Control Consortium; DCCT/EDIC Research Group, Newton-Cheh C, Eijgelsheim M, Rice K, de Bakker PI; QTGEN consortium, Pfeufer A, Sanna S, Arking DE; QTSCD consortium, Asselbergs FW, Spector TD, Carter ND, Jeffery S, Tobin M, Caulfield M, Snieder H, Paterson AD, Munroe PB, Jamshidi Y. Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS One. 2009 Jul 9;4(7):e6138 [PDF File]
Ornetti P, Brandt K, Hellio-le Graverand MP, Hochberg M, Hunter DJ, Kloppenburg M, Lane N, Maillefert JF, Mazzuca SA, Spector T, Utard-Wlerick G, Vignon E, Dougados M. OARSI-OMERACT definition of relevant radiological progression in hip/knee osteoarthritis. Osteoarthritis Cartilage. 2009 2009 Jul;17(7):842-9 [PDF File]
Perry JR, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, Cherkas L, Eiriksdottir G, Estrada K, Ferrucci L, Folsom AR, Garcia M, Gudnason V, Hofman A, Karasik D, Kiel DP, Launer LJ, van Meurs J, Nalls MA, Rivadeneira F, Shuldiner AR, Singleton A, Soranzo N, Tanaka T, Visser JA, Weedon MN, Wilson SG, Zhuang V, Streeten EA, Harris TB, Murray A, Spector TD, Demerath EW, Uitterlinden AG, Murabito JM. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet. 2009 May 17. [Epub ahead of print] PubMed PMID: 19448620. [PDF File]
Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, Cervino A, Coin L, Collins FS, Crisponi L, de Geus EJ, Dehghan A, Deloukas P, Doney AS, Elliott P, Freimer N, Gateva V, Herder C, Hofman A, Hughes TE, Hunt S, Illig T, Inouye M, Isomaa B, Johnson T, Kong A, Krestyaninova M, Kuusisto J, Laakso M, Lim N, Lindblad U, Lindgren CM, McCann OT, Mohlke KL, Morris AD, Naitza S, Orrù M, Palmer CN, Pouta A, Randall J, Rathmann W, Saramies J, Scheet P, Scott LJ, Scuteri A, Sharp S, Sijbrands E, Smit JH, Song K, Steinthorsdottir V, Stringham HM, Tuomi T, Tuomilehto J, Uitterlinden AG, Voight BF, Waterworth D, Wichmann HE, Willemsen G, Witteman JC, Yuan X, Zhao JH, Zeggini E, Schlessinger D, Sandhu M, Boomsma DI, Uda M, Spector TD, Penninx BW, Altshuler D, Vollenweider P, Jarvelin MR, Lakatta E, Waeber G, Fox CS, Peltonen L, Groop LC, Mooser V, Cupples LA, Thorsteinsdottir U, Boehnke M, Barroso I, Van Duijn C, Dupuis J, Watanabe RM, Stefansson K, McCarthy MI, Wareham NJ, Meigs JB, Abecasis GR. Variants in MTNR1B influence fasting glucose levels. Nat Genet. 2009 Jan;41(1):77-81.[PDF File]
Rahmioglu N, Andrew T, Cherkas L, Surdulescu G, Swaminathan R, Spector T, Ahmadi KR. Epidemiology and Genetic Epidemiology of the Liver Function Test Proteins. PLoS ONE. 2009;4(2):e4435 [PDF File]
Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M, Zhao JH, Ramasamy A, Zhai G, Vitart V, Huffman JE, Igl W, Albrecht E, Deloukas P, Henderson J, Granell R, McArdle WL, Rudnicka AR; Wellcome Trust Case Control Consortium, Barroso I, Loos RJ, Wareham NJ, Mustelin L, Rantanen T, Surakka I, Imboden M, Wichmann HE, Grkovic I, Jankovic S, Zgaga L, Hartikainen AL, Peltonen L, Gyllensten U, Johansson A, Zaboli G, Campbell H, Wild SH, Wilson JF, Gläser S, Homuth G, Völzke H, Mangino M, Soranzo N, Spector TD, Polašek O, Rudan I, Wright AF, Heliövaara M, Ripatti S, Pouta A, Naluai AT, Olin AC, Torén K, Cooper MN, James AL, Palmer LJ, Hingorani AD, Wannamethee SG, Whincup PH, Smith GD, Ebrahim S, McKeever TM, Pavord ID, Macleod AK, Morris AD, Porteous DJ, Cooper C, Dennison E, Shaheen S, Karrasch S, Schnabel E, Schulz H, Grallert H, Bouatia-Naji N, Delplanque J, Froguel P, Blakey JD; The NSHD Respiratory Study Team, Britton JR, Morris RW, Holloway JW, Lawlor DA, Hui J, Nyberg F, Jarvelin MR, Jackson C, Kähönen M, Kaprio J, Probst-Hensch NM, Koch B, Hayward C, Evans DM, Elliott P, Strachan DP, Hall IP, Tobin MD. Genome-wide association study identifies five loci associated with lung function. Nat Genet. 2010 Jan;42(1):36-44. Epub 2009 Dec 13. [PDF File]
Richards JB, Kavvoura FK, Rivadeneira F, Styrkársdóttir U, Estrada K, Halldórsson BV, Hsu YH, Zillikens MC, Wilson SG, Mullin BH, Amin N, Aulchenko YS, Cupples LA, Deloukas P, Demissie S, Hofman A, Kong A, Karasik D, van Meurs JB, Oostra BA, Pols HA, Sigurdsson G, Thorsteinsdottir U, Soranzo N, Williams FM, Zhou Y, Ralston SH, Thorleifsson G, van Duijn CM, Kiel DP, Stefansson K, Uitterlinden AG, Ioannidis JP, Spector TD; Genetic Factors for Osteoporosis Consortium. Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med. 2009 Oct 20;151(8):528-37 [PDF File]
Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, Perry JR, Tanaka T, Timpson NJ, Semple RK, Soranzo N, Song K, Rocha N, Grundberg E, Dupuis J, Florez JC, Langenberg C, Prokopenko I, Saxena R, Sladek R, Aulchenko Y, Evans D, Waeber G, Erdmann J, Burnett MS, Sattar N, Devaney J, Willenborg C, Hingorani A, Witteman JC, Vollenweider P, Glaser B, Hengstenberg C, Ferrucci L, Melzer D, Stark K, Deanfield J, Winogradow J, Grassl M, Hall AS, Egan JM, Thompson JR, Ricketts SL, König IR, Reinhard W, Grundy S, Wichmann HE, Barter P, Mahley R, Kesaniemi YA, Rader DJ, Reilly MP, Epstein SE, Stewart AF, Van Duijn CM, Schunkert H, Burling K, Deloukas P, Pastinen T, Samani NJ, McPherson R, Davey Smith G, Frayling TM, Wareham NJ, Meigs JB, Mooser V, Spector TD; GIANT Consortium. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 2009 Dec;5(12):e1000768. Epub [PDF File]
Rivadeneira F, Styrkársdottir U, Estrada K, Halldórsson BV, Hsu YH, Richards JB, Zillikens MC, Kavvoura FK, Amin N, Aulchenko YS, Cupples LA, Deloukas P, Demissie S, Grundberg E, Hofman A, Kong A, Karasik D, van Meurs JB, Oostra B, Pastinen T, Pols HA, Sigurdsson G, Soranzo N, Thorleifsson G, Thorsteinsdottir U, Williams FM, Wilson SG, Zhou Y, Ralston SH, van Duijn CM, Spector T, Kiel DP, Stefansson K, Ioannidis JP, Uitterlinden AG. The Genetic Factors for Osteoporosis (GEFOS) Consortium. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet. 2009 Nov;41(11):1199-206 [PDF File]
Soranzo N, Rendon A, Gieger C, Jones CI, Watkins NA, Menzel S, Doring A, Stephens J, Prokisch H, Erber W, Potter SC, Bray SL, Burns P, Jolley J, Falchi M, Kuhnel B, Erdmann J, Schunkert H, Samani N, Illig T, Garner SF, Rankin A, Meisinger C, Bradley JR, Thein SL, Goodall AH, Spector TD, Deloukas P, Ouwehand WH. A novel variant on chromosome 7Q22.3 associated with mean platelet volume, counts and function. Blood. 2009 Apr 16;113(16):3831-7 [PDF File]
Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M, Salo P, Voight BF, Burns P, Laskowski RA, Xue Y, Menzel S, Altshuler D, Bradley JR, Bumpstead S, Burnett MS, Devaney J, Döring A, Elosua R, Epstein SE, Erber W, Falchi M, Garner SF, Ghori MJ, Goodall AH, Gwilliam R, Hakonarson HH, Hall AS, Hammond N, Hengstenberg C, Illig T, König IR, Knouff CW, McPherson R, Melander O, Mooser V, Nauck M, Nieminen MS, O'Donnell CJ, Peltonen L, Potter SC, Prokisch H, Rader DJ, Rice CM, Roberts R, Salomaa V, Sambrook J, Schreiber S, Schunkert H, Schwartz SM, Serbanovic-Canic J, Sinisalo J, Siscovick DS, Stark K, Surakka I, Stephens J, Thompson JR, Völker U, Völzke H, Watkins NA, Wells GA, Wichmann HE, Van Heel DA, Tyler-Smith C, Thein SL, Kathiresan S, Perola M, Reilly MP, Stewart AF, Erdmann J, Samani NJ, Meisinger C, Greinacher A, Deloukas P, Ouwehand WH, Gieger C. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet. 2009 Nov;41(11):1182-90 [PDF File]
Skidmore PM, Cassidy A, Swaminathan R, Richards JB, Mangino M, Spector TD, Macgregor AJ. An obesogenic postnatal environment is more important than the fetal environment for the development of adult adiposity: a study of female twins. Am J Clin Nutr. 2009 Aug;90(2):401-6 [PDF File]
Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB, Hammond N, Stolk L, Nica A, Inouye M, Hofman A, Stephens J, Wheeler E, Arp P, Gwilliam R, Jhamai PM, Potter S, Chaney A, Ghori MJ, Ravindrarajah R, Ermakov S, Estrada K, Pols HA, Williams FM, McArdle WL, van Meurs JB, Loos RJ, Dermitzakis ET, Ahmadi KR, Hart DJ, Ouwehand WH, Wareham NJ, Barroso I, Sandhu MS, Strachan DP, Livshits G, Spector TD, Uitterlinden AG, Deloukas P. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. PLoS Genet. 2009 Apr;5(4):e1000445 [PDF File]
Stolk L, Zhai G, van Meurs JB, Verbiest MM, Visser JA, Estrada K, Rivadeneira F, Williams FM, Cherkas L, Deloukas P, Soranzo N, de Keyzer JJ, Pop VJ, Lips P, Lebrun CE, van der Schouw YT, Grobbee DE, Witteman J, Hofman A, Pols HA, Laven JS, Spector TD, Uitterlinden AG. Loci at chromosomes 13, 19 and 20 influence age at natural menopause. Nat Genet. 2009 May 17. [Epub ahead of print] PubMed PMID: 19448619. [PDF File]
Sun C, Zhu G, Wong TY, Hewitt AW, Ruddle JB, Hodgson L, Montgomery GW, Young TL, Hammond CJ, Craig JE, Martin NG, He M, Mackey DA. Quantitative genetic analysis of the retinal vascular caliber: the Australian Twins Eye Study. Hypertension 2009 Oct;54(4):788-95. [PDF File]
Timpson NJ, Tobias JH, Richards JB, Soranzo N, Duncan EL, Sims AM, Whittaker P, Kumanduri V, Zhai G, Glaser B, Eisman J, Jones G, Nicholson G, Prince R, Seeman E, Spector T, Brown MA, Peltonen L, Smith GD, Deloukas P, Evans DM. Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Hum Mol Genet. 2009 Apr 15;18(8):1510-7 [PDF File]
Valdes AM, Lories RJ, van Meurs JB, Kerkhof H, Doherty S, Hofman A, Hart DJ, Zhang F, Luyten FP, Uitterlinden AG, Doherty M, Spector TD. Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women. Arthritis Rheum. 2009 Jun 29;60(7):2046-2054. [PDF File]
Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Med Clin North Am. 2009 Jan;93(1):45-66 (no pdf available at present)
Vink JM, Smit AB, de Geus EJ, Sullivan P, Willemsen G, Hottenga JJ, Smit JH, Hoogendijk WJ, Zitman FG, Peltonen L, Kaprio J, Pedersen NL, Magnusson PK, Spector TD, Kyvik KO, Morley KI, Heath AC, Martin NG, Westendorp RG, Slagboom PE, Tiemeier H, Hofman A, Uitterlinden AG, Aulchenko YS, Amin N, van Duijn C, Penninx BW, Boomsma DI. Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet. 2009 Mar;84(3):367-79 [PDF File]
Veselka L, Schermer JA, Petrides KV, Cherkas LF, Spector TD, Vernon PA. A General Factor of Personality: Evidence from the HEXACO Model and a Measure of Trait Emotional Intelligence. Twin Res Hum Genet. 2009 Oct;12(5):420-4
Wang X, Ding X, Su S, Spector TD, Mangino M, Iliadou A, Snieder H. Heritability of insulin sensitivity and lipid profile depend on BMI: evidence for gene-obesity interaction. Diabetologia 2009 Dec;52(12):2578-84 [PDF File]
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of ANthropometric Traits Consortium. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009 Jan;41(1):25-34.[PDF File]
Williams FM, Carter AM, Kato B, Falchi M, Bathum L, Surdulescu G, Kyvik KO, Palotie A, Spector TD, Grant PJ; on Behalf of the EuroCLOT Investigators. Identification of Quantitative Trait Loci for Fibrin Clot Phenotypes. The EuroCLOT Study. Arterioscler Thromb Vasc Biol. 2009;29: 600-605 [PDF File]
Williams FM, Spector TD. A new 5-lipoxygenase inhibitor seems to be safe and effective for the treatment of osteoarthritis. Nat Clin Pract Rheumatol. 2009 Mar;5(3):132-3 [PDF File]
Wilson SG, Jones MR, Mullin BH, Dick IM, Richards JB, Pastinen TM, Grundberg E, Ljunggren O, Surdulescu GL, Dudbridge F, Elliott KS, Cervino AC, Spector TD, Prince RL. Common Sequence Variation in FLNB Regulates Bone Structure in Women in the General Population and FLNB mRNA Expression in Osteoblasts in Vitro. J Bone Miner Res. 2009 Dec;24(12):1989-97.
Zhai G, van Meurs JB, Livshits G, Meulenbelt I, Valdes AM, Soranzo N, Hart D, Zhang F, Kato BS, Richards B, Williams FM, Inouye M, Kloppenburg M, Deloukas P, Slagboom E, Uitterlinden A, Spector TD. A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium. J Med Genet. 2009 Sep;46(9):614-6. [PDF File]
2008
Anderson CA, Zhu G, Falchi M, van den Berg SM, Treloar SA, Spector TD, Martin NG, Boomsma DI, Visscher PM, Montgomery GW. A genome-wide linkage scan for age-at-menarche in three populations of European descent. J Clin Endocrinol Metab. 2008 October; 93 (10):3965-3970 [PDF File]
Andrew T, Maniatis N, Carbonaro F, Liew SH, Lau W, Spector TD, Hammond CJ. Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping. PLoS Genet. 2008 Oct;4(10):e1000220 [PDF File]
Bataille V, de Vries E. Melanoma-Part 1: epidemiology, risk factors, and prevention. BMJ. 2008 Nov 20;337:a2249 [PDF File]
Bruyere O, Delferriere D, Roux C, Wark JD, Spector T, Devogelaer JP, Brixen K, Adami S, Fechtenbaum J, Kolta S, Reginster JY. Effects of strontium ranelate on spinal osteoarthritis progression. Ann Rheum Dis. 2008 Mar;67(3):335-9. [PDF File]
Burri AV, Spector TD. The genetics of female sexual behaviour. Sexuality, Reproduction and Menopause 2008; 8:23-27 [PDF File]
Carbonaro F, Andrew T, Mackey DA, Spector TD, Hammond CJ. Heritability of intraocular pressure: a classical twin study. Br J Ophthalmol. 2008 Aug;92(8):1125-8 [PDF File]
Cherkas LF, Hunkin JL, Kato B, Richards B, Gardner JP, Surdulescu GL, Kimura M, Lu X, Spector TD, Aviv A. The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med 2008; 168 (2):154-158 [PDF File]
Chinappen-Horsley U, Blake GM, Fogelman I, Kato B, Ahmadi KR, Spector TD. Quantitative trait loci for bone lengths on chromosome 5 using dual energy X ray absorptiometry imaging in the twins UK cohort. PLOS One 2008; 3 (3):e1752 [PDF File]
Dalageorgou C, Ge D, Jamshidi Y, Nolte IM, Riese H, Savelieva I, Carter ND, Spector TD, Snieder H. Heritability of QT Interval: How Much Is Explained by Genes for Resting Heart Rate? J Cardiovasc Electrophysiol. 2008; 19 (4):386-91 [PDF File]
Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, Mychaleckyj JC, Todd JA, Bonella P, Fear AL, Lavant E, Louey A, Moonsamy P; Type 1 Diabetes Genetics Consortium. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes. 2008 Apr;57(4):1084-92 [PDF File]
Falchi M. Analysis of quantitative trait loci. Methods Mol Biol. 2008;453:297-326.PMID: 18712311
Falchi M, Wilson SG, Paximadas D, Swaminathan R, Spector TD. Quantitative Linkage Analysis for Pancreatic B-cell Function and Insulin Resistance in a Large Twin Cohort. Diabetes. 2008;57 (4):1120-4 [PDF File]
Falchi M, Fuchsberger C. Jenti: An efficient tool for mining complex inbred genealogies.Bioinformatics. 2008 Mar 1;24(5):724-6 [PDF File]
Fogelman I, Fordham JN, Fraser WD, Spector TD, Christiansen C, Morris SA, Fox J. Parathyroid hormone(1-84) treatment of postmenopausal women with low bone mass receiving hormone replacement therapy. Calcif Tissue Int. 2008 Aug;83(2):85-92 [PDF File]
Fuchsberger C, Falchi M, Forer L, Pramstaller PP. PedVizApi: a Java API for the interactive, visual analysis of extended pedigrees.Bioinformatics. 2008 Jan 15;24(2):279-81 [PDF File]
Ge D, Gooljar SB, Kyriakou T, Collins LJ, Swaminathan R, Snieder H, Spector TD, O'Dell SD. Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile. Obesity Research 2008 Feb; 16 (2):492-6 [PDF File]
Goyenechea E, Collins LJ, Parra D, Liu G, Snieder H, Swaminathan R, Spector TD, Martínez JA, and O’Dell SD CD36 gene promoter polymorphisms are associated with low density lipoprotein-cholesterol in normal twins and after a low-calorie diet in obese subjects. Twin Research and Human Genetics 2008 Dec;11(6):621-8 [PDF File]
Harris JM, Cherkas LF, Kato BS, Spector TD, Heiman JR. Normal Variations in Personality are Associated with Coital Orgasmic Infrequency in Heterosexual Women: A Population-Based Study. J Sex Med. 2008 May;5(5):1177-83 [PDF File]
Healey P, Carbonaro F, Taylor B, Spector TD, Mitchell P, Hammond CJ. The heritability of optic disc parameters: a classic twin study. Invest Ophthalmol Vis Sci. 2008 Jan;49(1):77-80 [PDF File]
Healy DG, Falchi M, O'Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S, Ferreira JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Schapira AH, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW; International LRRK2. Consortium. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol. 2008 Jul;7(7):583-90 [PDF File]
Kerkhof JM, Uitterlinden AG, Valdes AM, Hart DJ, Rivadeneira F, Jhamai M, Hofman A, Pols HA, Bierma-Zeinstra SM, Spector TD, van Meurs JB. Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. Osteoarthritis Cartilage. 2008 Oct;16(10):1141-9 [PDF File]
Keskitalo K, Tuorila H, Spector TD, Cherkas LF, Knaapila A, Kaprio J, Silventoinen K, Perola M. Three-factor eating questionnaire, body mass index, and responses to sweet and salty fatty foods: a twin study of genetic and environmental associations. American Journal of Clinical Nutrition 2008; 88:263-271 [PDF File]
Kimura M, Cherkas LF, Kato BS, Demissie S, Hjelmborg JB, Brimacombe M, Cupples A, Hunkin JL, Gardner JP, Lu X, Cao X, Sastrasinh M, Province MA, Hunt SC, Christensen K, Levy D, Spector TD, Aviv A. Offspring's leukocyte telomere length, pPaternal age, and telomere elongation in sperm. PLoS Genet. 2008 Feb 15;4(2):e37 [PDF File]
Kyriakou T, Collins LJ, Spencer-Jones NJ, Malcolm C, Wang X, Snieder H, Swaminathan R, Burling KA, Hart DJ, Spector TD, O'Dell SD. Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity. J Hum Genet. 2008;53:718-727 [PDF File]
Liu YZ, Wilson SG, Wang L, Liu XG, Guo YF, Li J, Yan H, Deloukas P, Soranzo N, Chinnapen-Horsley U, Cervino A, Williams FM, Xiong DH, Zhang YP, Jin TB, Levy S, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Spector TD, Deng HW. Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. PLoS ONE. 2008 Sep 8;3(9):e3160 [PDF File]
Lundmark PE, Liljedahl U, Boomsma DI, Mannila H, Martin NG, Palotie A, Peltonen L, Perola M, Spector TD, Syvänen C. Evaluation of HapMap data in six populations of European Descent. European Journal of Human Genetics 2008 Sep;16(9):1142-50 [PDF File]
Mullin BH, Prince RL, Dick IM, Islam FM, Hart DJ, Spector TD, Devine A, Dudbridge F, Wilson SG. Bone structural effects of variation in the TNFRSF1B gene encoding the tumor necrosis factor receptor 2. Osteoporos Int. 2008 Jul; 19 (7):961-8 [PDF File]
Mullin BH, Prince RL, Dick IM, Hart DJ, Spector TD, Dudbridge F, Wilson SG. Identification of a Role for the ARHGEF3 Gene in Postmenopausal Osteoporosis.Am J Hum Genet. 2008 June; 82 (6):1262-9 [PDF File]
Nicolaou N, Shane S, Cherkas L, Hunkin J, Spector TD. Is the tendency to engage in entrepreneurship genetic? Management Science 2008;54 (1):167-179 [PDF File]
Nicolau N, Shane S, Cherkas L, Spector TD. The influence of sensation seeking in the heritability of entrepreneurship. Strat. Entrepreneurship J 2008; 2: 7-21
Olano-Martin E, Abraham EC, Gill-Garrison R, Valdes AM, Grimaldi K, Tang F, Jackson KG, Williams CM, Minihane AM. Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender. J Lipid Res. 2008 May;49(5):945-53 [PDF File]
Panicker V, Wilson SG, Spector TD, Brown SJ, Falchi M, Richards JB, Surdulescu GL, Lim EM, Fletcher SJ, Walsh JP. Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort. Clin Endocrinol (Oxf). 2008;68(4):652-9 [PDF File]
Panicker V, Wilson SG, Spector TD, Brown SJ, Kato BS, Reed PW, Falchi M, Richards JB, Surdulescu GL, Lim EM, Fletcher SJ, Walsh JP. Genetic Loci linked to pituitary-thyroid axis set points: a genome-wide scan of a large twin cohort. J Clin Endocrinol Metab. 2008 Sep;93(9):3519-2 [PDF File]
Prainsack B., Reardon J. and etc. Misdirected precaution. Nature Vol456|6 2008 Nov 6;456(7218):34-5 [PDF File]
Reginster JY, Felsenberg D, Boonen S, Diez-Perez A, Rizzoli R, Brandi ML, Spector TD, Brixen K, Goemaere S, Cormier C, Balogh A, Delmas PD, Meunier PJ. Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial. Arthritis Rheum. 2008 May 31;58(6):1687-1695 [PDF File]
Richards JB, Rivadeneira F, Inouye M, Pastinen TM, Soranzo N, Wilson SG, Andrew T, Falchi M, Gwilliam R, Ahmadi KR, Valdes AM, Arp P, Whittaker P, Verlaan DJ, Jhamai M, Kumanduri V, Moorhouse M, van Meurs JB, Hofman A, Pols HAP, Hart D, Zhai G, Kato BS, Mullin BH, Zhang F, Deloukas P, Uitterlinden AG, Spector TD. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. The Lancet 2008 May 3; 371(9623):1505-12 [PDF File] [Suppl PDF]
Richards JB, Valdes AM, Gardner JP, Kato BS, Siva A, Kimura M, Lu X, Brown MJ, Aviv A, Spector TD. Homocysteine levels and leukocyte telomere length. Atherosclerosis 2008 Oct; 200(2):271-7 [PDF File]
Richards JB, Yuan X, Geller F, Waterworth D, Bataille V, Glass D, Song K, Waeber G, Vollenweider P, Aben KK, Kiemeney LA, Walters B, Soranzo N, Thorsteinsdottir U, Kong A, Rafnar T, Deloukas P, Sulem P, Stefansson H, Stefansson K, Spector TD, Mooser V.Male-pattern baldness susceptibility locus at 20p11. Nature Genetics 2008, Nov; 40(11): 1282-1284 [PDF File]
Rodriguez-Lopez J, Pombo-Suarez M, Loughlin J, Tsezou A, Blanco FJ, Meulenbelt I, Slagboom PE, Valdes AM, Spector TD, Gomez-Reino JJ, Gonzalez A. Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. Osteoarthritis Cartilage. 2008 2009 Mar;17(3):321-7 [PDF File]
Seeman E, Devogelaer JP, Lorenc R, Spector T, Brixen K, Balogh A, Stucki G, Reginster JY. Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia. J Bone Miner Res. 2008 Mar;23(3):433-8 [PDF File]
Skidmore PM, Cassidy A, Swaminathan R, Richards JB, Spector TD, Macgregor AJ. Relation of birth weight, BMI and change in size from birth to adulthood to insulin resistance in a female twin cohort. J Clin Endocrinol Metab. 2008; 93(2):516-20 [PDF File]
Snieder H, Wang X, Shiri-Sverdlov R, van Vliet-Ostaptchouk JV, Hofker MH, Perks U, Spector TD, O'Dell SD. TUB is a candidate gene for late-onset obesity in women. Diabetologia. 2008 Jan;51(1):54-61 [PDF File]
Spector TD, Calomme MR, Anderson SH, Clement G, Bevan L, Demeester N, Swaminathan R, Jugdaohsingh R, Vanden Berghe DA, Powell JJ. Choline-stabilized orthosilicic acid supplementation as an adjunct to Calcium/Vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. BMC Musculoskelet Disord. 2008 Jun 11;9(1):85 [PDF File]
Thomson G, Barcellos LF, Valdes AM. Searching for additional disease loci in a genomic region. Adv Genet. 2008;60:253-92.
Valdes AM, Doherty M, Spector TD. The additive effect of individual genes in predicting risk of knee osteoarthritis. Annals of Rheumatic Diseas 2008 Jan; 67 (1):124-7 [PDF File]
Valdes AM, Loughlin J, Timms KM, van Meurs JJB, Southam L, Wilson SG, Doherty S, Lories RJ, Luyten FP, Gutin A, Abkevich V, Dongliang G, Hofman A, Uitterlinden AG, Hart DJ, Zhang F, Zhai G, Egli RJ, Doherty M, Lanchbury J, Spector TD. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. The American Journal of Human Genetics 2008; 82:1-10 [PDF File]
Valdes AM, Spector TD, Doherty S, Wheeler M, Hart DJ, Doherty M. Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. Ann Rheum Dis. 2008 Dec 3 [PDF File]
Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Rheum Dis Clin North Am. 2008 Aug;34(3):581-603 [PDF File]
Vernon PA, Martin RA, Schermer JA, Cherkas LF, Spector TD. Genetic and environmental contributions to humor replication study. Twin Research and Human Genetics 2008; 11 (1): 44-47 [PDF File]
Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, Ahmadi KR et al. Genome-wide association study identifies novel genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. American Journal of Human Genetics 2008 Jan 10;82(1):139-149 [PDF File]
Whitehouse AJ, Spector TD, Cherkas LF. No clear genetic influences on the association between dyslexia and anxiety in a population-based sample of female twins. Dyslexia. 2008 Nov 24. [PDF File]
Williams F, Cherkas L, Bertolaccini M, Murru V, Surdulescu G, Hughes G, Khamashta M, Spector T, Macgregor A. Migraine and antiphospholipid antibodies: no association found in migraine-discordant monozygotic twins. Cephalalgia. 2008 Oct; 28(10): 1048-52 [PDF File]
Williams FM, Kato BS, Livshits G, Sambrook PN, Spector TD, Macgregor AJ. Lumbar disc disease shows linkage to chromosome 19 overlapping with a QTL for hand OA. Ann Rheum Dis. 2008 Jan; 67 (1):117-9 [PDF File]
Williams FM, Spector TD. Biomarkers in osteoarthritis. Arthritis Res Ther. 2008 Jan 16;10(1):101 [PDF File]
Williams FM, Spector TD. Are intra-articular injections of hylan more effective than injections of hyaluronic acid for knee osteoarthritis? Nat Clin Pract Rheumatol. 2008 Aug;4(8):400-1 [PDF File]
Zhai G, Andrew T, Kato BS, Blake GM, Spector TD. Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin study. Osteoporos Int. 2009 Jun;20(6):949-53 [PDF File]
Zhai G, Hart DJ, Valdes AM, Kato BS, Richards JB, Hakim A , Spector TD. Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population based study. Osteoporosis International 2008 Aug;19(8):1211-7 [PDF File]
2007
Cherkas LF, Williams FMK, Carter L, Howell K, Black CM, Spector TD, MacGregor AJ. The heritability of raynaud's phenomenon and vascular responsiveness to cold: a study of adult female twins. Arthritis Care & Research 2007; 57 (3):524-8[PDF File]
De Moor MH, Spector TD, Cherkas LF, Falchi M, Hottenga JJ, Boomsma DI & De Geus EJ. Genome-wide linkage scan for athlete status in 700 British female DZ twin pairs. Twin Res Hum Genet 2007 Dec;10(6):812-20.
Keskitalo K, Tuorila H, Spector TD, Cherkas LF, Knaapila A, Silventoinen K, Perola M. Same genetic components underlie different measures of sweet taste preference. Am J Clin Nutr. 2007 Dec;86(6):1663-9 [PDF File]
Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr 2007; 86: 1420-5 [PDF File]
Valdes AM, Loughlin J, VanOene M, Chapman K, Surdulescu GL, Doherty M, Spector TD. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis & Rheumatism 2007; 56(1):137-146 [PDF File]
Gosden RG, Treloar SA, Martin NG, Cherkas LF, Spector TD, Faddy MJ, Silber SJ. Prevalence of premature ovarian failure in monozygotic and dizygotic twins. Human Reproduction 2007; Feb 22(2):610-5 [PDF File]
Richards JB, Cherkas LF, Spector TD. An analysis of which anti-osteoporosis therapeutic regimen would improve compliance in a population of elderly adults. Current Medical Research Opinions 2007; 23(2):293-299 [PDF File]
Zhai G, Hart DJ, Kato BS, MacGregor A, Spector TD. Genetic influence on the progression of radiographic knee osteoarthritis: a longitudinal twin study. Osteoarthritis & Cartilage 2007;15:222-225 [PDF File]
Zhang F, Zhai G, Kato BS, Hart DJ, Hunter D, Spector TD, Ahmadi K. Association between KLOTHO gene and hand osteoarthritis in a female Caucasian population. Osteoarthritis & Cartilage 2007 June; 15 (6):624-9 [PDF File]
Steer SE, Williams FMK, Kato B, Gardner JP, Norman PJ, Hall MA, Kimura M, Vaughan R, Aviv A, Spector TD. Reduced telomere length in rheumatoid arthritis is independent of disease activity and duration. Ann Rheum Dis. 2007 Apr; 66 (4):476-480 [PDF File]
Ioannidis JP, Ng MY, Sham PC, Zintzaras E, Lewis C, Deng H, Econs MJ, Karasik D, Devoto M, Kammerer C, Spector TD, Andrew T, Cupples A, Foroud T, Keil D, Koller DL, Langdahl BL, Mitchell B, Peacock M, Recker R, Hui S, Katia S, Spotila L, Uitterlinden AG, Wilson S, Kung AW, Ralston SH. Meta-analysis of genome wide scans provides evidence for gender and site specific regulation of bone mass. JBMR 2007;22 (2):173-183 [PDF File]
Jamshidi Y, Gooljar SB, Snieder H, Wang X, Ge D, Swaminathan R, Spector TD. O'dell SD. SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women. Atherosclerosis 2007 Oct;194 (2):e26-33
Valdes AM, Richards JB, Gardner JP, Swaminathan R, Kimura M, Lu X, Aviv A, Spector TD. Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis. Osteoporosis Int 2007 Sep; 18 (9):1203-10 [PDF File]
Richards JB, Valdes AM, Burling K, Perks UC,Spector TD. Serum adiponectin and bone mineral density in women . Journal of Clinical Endocrinology & Metabolism 2007; 92(4):1517-1523 [PDF File]
Jamshidi Y, Snieder H, Ge D, Spector TD, O'Dell SD. The SH2B gene is associated with serum leptin and body fat in normal female twins. Obesity (Silver Spring) 2007 Jan; 15(1):5-9 [PDF File]
Zhai G, Ding C, Cicuttine F, Jones G. A longitudinal study of the association between knee alignment and change in cartilage volume and chondral defects in a largely non-osteoarthritic population. Journal of Rheumatology 2007 Jan; 34 (1):181-6 [PDF File]
Livshits G, Kato BS, Zhai G, Hart DJ, Hunter D, MacGregor AJ, Williams FMK, Spector TD. Genomewide linkage scan of hand osteoarthritis in female twin pairs showing replication of quantitative trait loci on chromosome 2 and 19. Ann Rheum Dis 2007; 66 (5):623-7 [PDF File]
Knaapila A, Tuorila H, Silventoinen K, Keskitalo K, Kallela M, Wessman M, peltonen L, Cherkas LF, Spector TD, Perola M. Food neophobia shows heritable variation in humans. Physiol Behav 2007 Aug 15;91(5):573-8[PDF File]
Williams FM, Manek NJ, Sambrook PN, Spector TD, MacGregor AJ. Schmorl's nodes: Common, highly heritable, and related to lumbar disc disease. Arthritis Care & Research 2007; 57 (5):855-860 [PDF File]
Healey PR, Mitchell P, Gilbert CE, Lee AJ, Ge D, Snieder H, Spector TD, Hammond CJ. The inheritance of peripapillary atrophy. Invest Ophthalmol Vis Sci. 2007 Jun; 48 (6):2529-34 [PDF File]
Mullin BH, Spector TD, Curtis CC, Ong GN, Hart DJ, Hakim AJ, Worthy T, Wilson SG. Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women. Calcif Tissue Int. 2007 Jul; 81 (1): 10-7 [PDF File]
Majava M, Bishop PN, Hagg P, Scott PG, Rice A, Inglehearn C, Hammond CJ, Spector TD, Ala-Kokko L, Mannikko M. Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopia. Hum Mutat 2007; 28 (4):336-44 [PDF File]
Menzel S, Garner C, Gut I, Matsuda F, Yamaguchi M, Heath S, Foglio M, Zelenika D, Boland A, Rooks H, Best S, Spector TD, Farrall M, Lathrop M, Thein SL. A QTL influencing F cell production maps to a gene encoding a Zinc-finger protein on chromososme 2p15. Nature Genetics 2007 Oct;39(10):1197-9 [PDF File]
Bataille V, Kato BS, Falchi M, Gardner J, Kimura M, Lens M, Perks U, Valdes AM, Bennett DC, Aviv A, Spector TD. Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo. Cancer Epidemiol Biomarkers Prev 2007;16(7):1499-502 [PDF File]
Thein SL, Menzel S, Peng X, Best S, Jiang J, Close J, Silver N, Gerovasilli A,Ping C, Yamaguchi M, Wahlberg K, Ulug P, Spector TD, Garner C, Matsuda F, Farrall M, Lathrop M. Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11346-51 [PDF File]
Jamshidi Y, Kyriakou T, Gooljar SB, Collins LJ, Lane CA, Snieder H, Wang X, Spector TD, O'dell SD. Common STAT3 Variants Are Not Associated With Obesity or Insulin Resistance in Female Twins. Obesity (Silver Spring). 2007 Jul;15(7):1634-1639 [PDF File]
Prainsack B, Cherkas LF, Spector TD. Attitudes towards human reproductive cloning, assisted reproduction and gene selection: a survey of 4600 British twins. Hum Reprod. 2007 Aug;22 (8):2302-8 [PDF File]
Bruyere O, Roux C, Detilleux J, Slosman DO, Spector TD, Fardellone P, Brixen K, Devogelaer JP, Diaz-Curiel M, Albanese C, Kaufman JM, Pors-Nielsen S, Reginster JY. Relationship between bone mineral density changes and fracture risk reduction in patients treated with strontium ranelate. J Clin Endocrinol Metab. 2007 Aug; 92(8):3076-81 [PDF File]
Perola M, Sammalisto S, Hiekkalinna T, Martin NG, Visscher PM, Montgomery GW, Benyamin B, Harris JR, Boomsma D, Willemsen G, Hottenga JJ, Christensen K, Kyvik KO, Sorensen TI, Pedersen NL, Magnusson PK, Spector TD, Widen E, Silventoinen K, Kaprio J, Palotie A, Peltonen L; GenomEUtwin Project. Combined Genome Scans for Body Stature in 6,602 European Twins: Evidence for Common Caucasian Loci. PLoS Genet. 2007 Jun 8;3(6):e97 [PDF File]
Livshits G, Kato BS, Wilson SG, Spector TD. Linkage of genes to total lean body mass in normal women. J Clin Endocrinol Metab. 2007 Aug; 92(8):3171-6 [PDF File]
Zhang F, Kato BS, Gardner JP, Kimura M, Spector TD, Ahmadi KR. Lack of association between leukocyte telomere length and genetic variants in two ageing-related candidate genes. Mech Ageing Dev. 2007 Jul-Aug; 128 (7-8):415-22 [PDF File]
Zhai G, Valdes AM, Cherkas L, Clement G, Strachan D, Spector TD.The Interaction of Genes and Smoking on Forced Expiratory Volume: A Classic Twin Study. Chest 2007 Dec; 132 (6):1772-7 [PDF File]
Teucher B, Skinner J, Skidmore PM, Cassidy A, Fairweather-Tait SJ, Hooper L, Roe MA, Foxall R, Oyston SL, Cherkas LF, Perks UC, Spector TD, MacGregor AJ. Dietary patterns and heritability of food choice in a UK female twin cohort. Twin Res Hum Genet. 2007 Oct; 10 (5):734-48 [PDF File]
Siva A, De Lange M, Clayton D, Monteith S, Spector TD, Brown MJ. The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway. QJ Med. 2007 Aug;100 (8):495-9
Chinappen-Horsley U, Blake GM, Fogelman I, Spector TD. A Method for Determining Skeletal Lengths from DXA Images. BMC Musculoskelet Disord. 2007 Nov 16;8(1):113
Barwell J, Pangon L, Georgiou A, Docherty Z, Kesterton I, Ball J, Camplejohn R, Berg J, Aviv A, Gardner J, Kato BS, Carter N, Paximadas D, Spector TD, Hodgson S. Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity? Br J Cancer. 2007 Dec 17; 97 (12):1696-700 [PDF File]
Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr. 2007 Nov;86(5):1420-1425. [PDF File]
Krzeski P, Buckland-Wright C, Balint G, Cline GA, Stoner K, Lyon R, Beary J, Aronstein WS, Spector TD. Development of musculoskeletal toxicity without clear benefit after administration of PG 116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12 month, double-blind, placebo-controlled study. Arthritis Res Ther. 2007 Oct 24;9(5):R109 [PDF File]
Williams FM, Spector TD. The genetics of osteoporosis. Acta Reumatol Port. 2007 Jul-Sep;32(3):231-40.[PDF File]
Carter AM, Cymbalista CM, Spector TD, Grant PJ; EuroCLOT Investigators. Heritability of clot formation, morphology, and lysis: the EuroCLOT study. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2783-9. [PDF File]
Norbury TA, MacGregor AJ, Urwin J, Spector TD, McMahon SB. Heritability of responses to painful stimuli in women: a classical twin study. Brain. 2007 Nov;130(Pt 11):3041-9. [PDF File]
Ring HZ, Valdes AM, Nishita DM, Prasad S, Jacob P 3rd, Tyndale RF, Swan GE, Benowitz NL. Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism. Pharmacogenet Genomics. 2007 Dec;17(12):1007-15
Arkadianos I, Valdes AM, Marinos E, Florou A, Gill RD, Grimaldi KA. .Improved weight management using genetic information to personalize a calorie controlled diet. Nutr J. 2007 Oct 18;6:29
Thomson G, Valdes AM, Noble JA, Kockum I, Grote MN, Najman J, Erlich HA, Cucca F, Pugliese A, Steenkiste A, Dorman JS, Caillat-Zucman S, Hermann R, Ilonen J, Lambert AP, Bingley PJ, Gillespie KM, Lernmark A, Sanjeevi CB, Rønningen KS, Undlien DE, Thorsby E, Petrone A, Buzzetti R, Koeleman BP, Roep BO, Saruhan-Direskeneli G, Uyar FA, Günoz H, Gorodezky C, Alaez C, Boehm BO, Mlynarski W, Ikegami H, Berrino M, Fasano ME, Dametto E, Israel S, Brautbar C, Santiago-Cortes A, Frazer de Llado T, She JX, Bugawan TL, Rotter JI, Raffel L, Zeidler A, Leyva-Cobian F, Hawkins BR, Chan SH, Castano L, Pociot F, Nerup J. Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis. Tissue Antigens. 2007 Aug;70(2):110-27 [PDF File]
Swan GE, Jack LM, Valdes AM, Ring HZ, Ton CC, Curry SJ, McAfee T. Joint effect of dopaminergic genes on likelihood of smoking following treatment with bupropion SR. Health Psychol. 2007 May;26(3):361-8
Steenkiste A, Valdes AM, Feolo M, Hoffman D, Concannon P, Noble J, Schoch G, Hansen J, Helmberg W, Dorman JS, Thomson G, Pugliese A; 13th IHWS 1 Diabetes Component participating investigators. 14th International HLA and Immunogenetics Workshop: report on the HLA component of type 1 diabetes. Tissue Antigens. 2007 Apr;69 Suppl 1:214-25.
2006
De Lange M, Andrew T, Snieder H, Ge D, Futers TS, Standeven K, Spector TD, Grant PJ, Ariens RAS. Joint linkage and association of 6 single nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus . Arterioscler Thromb Vasc Biol 2006 Aug; 26 (8):1914-9
Reavley CM, Golding JF, Cherkas LF, Spector TD, MacGregor AJ. Genetic influences on motion sickness susceptibility in adult women: a classical twin study. Aviat Space Environ Med 2006 Nov; 77 (11): 1148-52
Spector TD, Williams FM.The UK Adult Twin Registry (TwinsUK). Twin Reserch and Human Genetics 2006; 9 (6): 899-906 [PDF]
Majava M, Bishop PN, Hagg P, Scott PG, Rice A, Inglehearn C, Hammond CJ, Spector TD, Ala -Kokko L, Mannikko M. Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopia . Hum Mutat 2006 Nov 20; 28 (4):336-344
Harding B, Curley AJ, Hannan FM, Christie PT, Bowl MR, Turner JJO, Barber M, Gillham-Nasenya I, Hampson G, Spector TD, Thakker RV. Functional characterization of calcium sensing receptor polymorphisms and absence of association with indices of calcium homeostasis and bone mineral density. Clinical Endocrinology 2006;65:598-605 [PDF File]
Williams FMK, Spector TD. Osteoarthritis. Medicine 2006; 34 (9): 364-368 [PDF File]
Falchi M, Spector TD, Perks U, Kato BS, Bataille V. Genome-wide search for nevus density shows linkage to two melanoma loci on chromosome 9 and identifies a new QTL on 5q31 in an adult twin cohort. Human Molecular Genetics 2006; 15 (20):2975-9 [PDF File]
Zhai G, Aviv A, Hunter DJ, Hart DJ, Gardner JP, Kimura M, Lu X, Valdes AM, Spector TD. Reduction of leukocyte telomere length in radiographic hand osteoarthritis: a population based study. Ann Rheum Disease 2006; 65 (11):1444-1448 [PDF File]
Skidmore PML, Cassidy A, Swaminathan R, Falchi M, Spector TD, MacGregor AJ. Intrauterine, environmental, and genetic influences in the relationship between birth weight and lipids in a female twin cohort. Arterioscler. Thromb. Vasc. Biol 2006; 26(10):2373-9 [PDF File]
Camplejohn RS, Hodgson S, Carter N, Kao BS, Spector TD. Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins. British Journal of Cancer 2006; 95:520-524.[PDF File]
Aviv A, Valdes A, Spector TD. Human telomere biology: pitfalls of moving from the laboratory to epidemiology. International Journal of Epidemiology 2006 Dec; 35:1424-1429 [PDF File]
Bingham CO, Buckland-Wright JC, Garnero P, Cohen SB, Dougados M, Adami S, Clauw DJ, Spector TD, Pelletier JP, Raynauld JP, Strand V, Simon LS, Meyer JM, Cline GA, Beary JF. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow x-ray progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee OA structural arthritis (KOSTAR) study. Arthritis & Rheumatism 2006 Nov; 54(11):3494-507 [PDF File]
Jamshidi Y, Snieder H, Wang X, Pavitt MJ, Spector TD, Carter ND, O'Dell SD. Phosphatidylinositol 3-kinase p85 alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population. Diabetology 2006 Nov;49 (11):2659-2667 [PDF File]
Spencer-Jones NJ, Ge D, Snieder H, Perks U, Swaminathan R, Spector TD, Carter ND, O'Dell SD. AMP-Kinase ALPHA2 subunit gene PRKAA2 variants are associated with total LDL and HDL-cholesterol normal females. J Med Genet 2006; 43 (12): 936-42 [PDF File]
Cherkas LF, Aviv A, Valdes AM, Hunkin JL, Gardner JP, Surdulescu GL, Kimura M, Spector TD. The effects of social status on biological ageing as measured by white cell telomere length. Aging Cell 2006; 5 (5): 361-365 [PDF File]
Prainsack B, Spector TD, Cherkas L. The cloning experience: twins and human reproductive cloning. Social Science and Medicine 2006;63:2739-2752 [PDF File]
Williams FM, Spector TD. Recent advances in the genetics of osteoporosis. J Musculoskelet Neuronal Interact 2006; 6(1): 27-35 [PDF File]
Need AC, Ahmadi KR, Spector TD, Goldstein DB. Obesity is associated with genetic variants that alter dopamine availability . Ann Hum Genet 2006;70 (Pt3): 293-303
Hasset G, Hart DJ, Doyle D, March L, Spector TD. The relationship of progressive osteoarthritis of the knee and long-term progression of osteoarthritis of the hand, hip and lumbar spine. Ann Rheum Dis 2006;65(5): 623-8. [PDF File]
Jiang J, Best S, Menzel S, Silver N, Lai MI, Surdulescu Gl, Spector TD, Thein SL. cMYB is involved in the regulation of fetal hemoglobin production in adults. Blood 2006; 108 (3):1077-1083. [PDF File]
De Lange M, Andrew T, Snieder H, Ge D, Futers TS, Standeven K, Spector TD, Grant PJ, Ariens RAS. Joint linkage and association of 6 single nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus. Arterioscler Thromb Vasc Biol 2006; 26: 1914-1919. [PDF File]
Spector TD, Ahmadi KR, Valdes AM. When is a replication not a replication? Or how to spot a good genetic association study. Arthritis & Rheumatism 2006; 54 (4): 1051-1054. [PDF File]
Paul SN, Kato BS, Cherkas LF, Andrew T, Spector TD. Heritability of the second to fourth digit ratio (2d:4d): A twin study. Twin Research and Human Genetics 2006; 9 (2): 215-219 [PDF File]
Valdes A, Van Oene M, Hart DJ, Surdulescu GL, Loughlin J, Doherty M, Spector TD. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis & Rheumatism 2006; 54 (2): 533-539 [PDF File]
Wilson S, Adam G, Langdown M, Reneland R, Braun A, Andrew T, Surdulescu GL, Norberg M, Dudbridge F, Reed PW, Sambrook P, Kleyn PW, Spector TD. Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in female dizygous twin cohort. European Journal of Human Genetics 2006; 14: 340-348. [PDF File]
Garner C, Best S, Menzel S, Rooks H, Spector TD, Thein SL. Two candidate genes for low platelet count identified in an Asian indian kindred by genome-wide linkage analysis: glycoprotein IX and thrombopoietin. European Journal of Human Genetics 2006 ; 14 (1): 101-8.
Andrew T, Aviv A, Falchi M, Surdulescu GL, Gardner JP, LU X, Kimura M, Kato BS, Valdes AM, Spector TD. Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sib-pairs. American Journal of Human Genetics. January 2006; 78 (3):480-6. [PDF File]
Sutcliffe A, Spoudeas HA, Devaki N, Bouloux P, Oliver T, Sambrook P, Bannister W, Lambalk CB, Spector TD. Comparison of serum FSH and inhibin B levels between adult male dizygotic and monozygotic twins. Human Reproduction 2006; 21: 447-450.[PDF File]
Jamshidi Y, Snieder H, Wang X, Spector TD. Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins. Diabetologia 2006; 49 (2): 306-310. [PDF File]
Singer JJ, MacGregor AJ, Cherkas LF, Spector TD. Genetic influences on cognitive function using The Cambridge Neuropsychological Test Automated Battery. Intelligence 2006; 34:421-428 [PDF File]
Liew SH, Gilbert CE, Spector TD, Mellerio M, Kuijk FJ, Beatty S, Fitzke F, Marshall J, Hammond CJ. Central retinal thickness is positively correlated with macular pigment optical density. Exp Eye Res. 2006; 82 (5): 915-20. [PDF File]
Aviv A, Valdes AM, Gardner JP, Swaminatahan R, Kimura M, Spector TD. Menopause modifies the association of telomere length in white blood cells with insulin resistance in normal females. The Journal of Clinical Endocrinology & Metabolism 2006; 91 (2): 635-40. [PDF File]
Spector TD. Doxycycline and osteoarthritis: what does it show us? Nature Clinical Practice Rheumatology 2006; 2 (2):66-7 [PDF File]
Spector TD, Reneland RH, Mah S, Valdes AM, Hart DJ, Kammerer S, Langdown M, Hoyal CR, Atienza J, Doherty M, Rahman P, Nelson MR, Braun A. Association between a variation in LRCH1 and knee osteoarthritis: A genome-wide SNP association study using DVA pooling. Arthritis & Rheumatism 2006; 54 (2): 524-32. [PDF File]
Stubbe JH, Boomsma DI, Vink JM, Cornes BK, Martin NG, Skytthe A, Kyvik KO, Rose RJ, Kujala UM, Kaprio J, Harris JR, Pedersen NL, Hunkin J, Spector TD, de Geus EJ. Genetic influences on exercise participation in 37,051 twin pairs from seven countries. PLoS ONE. 2006 Dec 20;1:e22. [PDF File]
Blake GM, Knapp KM, Spector TD, Fogelman I. Predicting the risk of fracture at any site in the skeleton: are all bone mineral density measurement sites equally effective? Calcif Tissue Int. 2006; 78 (1): 9-17. [PDF File]
Williams FMK, Andrew T, Saxne T, Heinegard D, Spector TD, MacGregor AJ. The heritable determinants of cartilage oligomeric matrix protein (COMP). Arthritis & Rheumatism 2006;54 (7):2147-51 [PDF File]
Maheu E, Altman RD, Bloch DA, Doherty M, Hochberg M, Mannoni A, Punzi L, Spector TD, Verbruggen G, Carr A, Cicuttini F, Dreiser RL, Haraoui BP, Hart D, Pelletier JP, Ramonda R, Rovati L. Design and conduct of clinical trials in patients with osteoarthritis of the hand: recommendations from a task force of the Osteoarthritis Research Society International. Osteoarthritis & Cartilage 2006; 14: 303-322. [PDF File]
Paul SN, Kato BS, Hunkin JL, Vivekanandan S, Spector TD. The big finger: the second to fourth digit ratio is a predictor of sporting ability in women. British Journal of Sports Medicine 2006 Dec; 40 (12):981-3 [PDF File]
Cohen RM, Snieder H, Lindsell CJ, Beyan H, Hawa MI, Blinko S, Edwards R, Spector TD, Leslie RDG. Evidence for independent heritability of the glycation gap (glycosylation gap) fraction of HbA1c in nondiabetic twins. Diabetes Care 2006; 29 (8):1739-1743 [PDF File]
Singer JJ, Falchi M, MacGregor AJ, Cherkas LF, Spector TD. Genome-wide scan for prospective memory suggests linkage to chromosome 12q22. Behav Genet 2006 Jan; 36 (1):18-28. [PDF File]
Back to Top2005
Williams FM, Cherkas LF, Spector TD, MacGregor AJ. The effect of moderate alcohol consumption on bone mineral density: a study of female twins. Ann Rheum Dis. 2005 Feb;64 (2):309-10 [PDF File]
Garner C, Menzel S, Martin N, Best S, Spector TD, Thein SL. Interacion between two quantitatie trait loci affects fetal haemoglobin expression. Annals of Human Genetics 2005; 69: 707-714. [PDF File]
Spector TD. Strontium Ranelate (Protelos): new option in osteoporosis. Prescriber 2005; 16 (21): 21-27. [PDF File]
Hassett G, Hart DJ, Doyle D, March L, Spector TD. The realtionship of progressive osteoarthritis of the knee and long-term progression of osteoarthritis of the hand, hip and lumbar spine. Ann Rheum Dis 2005 [PDF File]
Mohammed I, Cherkas LF, Riley SA, Spector TD, Trudgill NJ. Genetic influences in irritable bowel syndrome: a twin study. American Journal of Gastroenterology 2005 Jun;100 (6):1340-4
Maheu E, Cadet C, Marty M, Dougados M, Ghabri S, Kerloch I, Mazieres B, Spector TD, Vignon E, Lequesne MG. Reproducibility and sensibility to change of various methods to measure joint space width in osteoarthritis of the hip: a double reading of three different radiographic views taken with a three-year interval. Arthritis Research & Therapy 2005; 7 (6): R1375-85. [PDF File]
Toh TY, Liew SHM, Mackinnon JR, Hewitt AW, Poulsen JL, Spector TD, Gilbert CE, Craig JE, Hammond CJ, Mackey DA. Central corneal thickness is highly heritable: The twin eye study. Investigative Ophthalmology & Visual Science 2005; 46 (10): 3718-3722. [PDF File]
Sutcliffe A, Spoudeas HA, Devaki N, Bouloux P, Oliver T, Sambrook P, Bannister W, Lambalk CB, Spector TD. Comparison of serum FSH and inhibin B levels between adult male dizygotic and monozygotic twins. Human Reproduction 2005. [PDF File]
Falchi M, Andrew T, Snieder H, Swaminathan R, Surdulescu G, Spector TD. The identification of QTLs for serum lipid levels in a female sib-pair cohort. A novel application to improve the power of two-locus linkage analysis. Hum Mol Genet 2005; 14 (20): 2971-9 [PDF File]
Roberts SC, Gosling LM, Spector TD, Miller P, Penn DJ, Petrie M. Body odour similarity in noncohabiting twins. Chemical Senses 2005; 30 (8): 651-6. [PDF File]
Liew SHM, Gilbery CE, Spector TD, Mellerio J, Marshall J, Van Kuijk FJGM, Beatty S, Fitzke F, Hammond CJ. Heritability of macular pigment: a twin study. Investigative Ophthalmology & Visual Science 2005; 46 (12): 4430-4436 [PDF File]
Spencer-Jones NJ, Snieder H, Wang X, Miller CSA, Spector TD, Carter ND, O'Dell SD. Protein tyrosine phosphatase-1B gene PTPN1: Selection of tagging SNPs and association with body fat, insulin sensitivity and the metabolic syndrome in a normal female population. Diabetes 2005; 54: 3296-3304. [PDF File]
Smith AJ, Gidley J, Sandy JR, Perry MJ, Elson CJ, Kirwan JR, Spector TD, Doherty M, Bidwell JL, Mansell JP. Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene: Are they a risk factor in osteoarthritis? Osteoarthritis Cartilage 2005 Jul; 13 (7): 608-13. [PDF File]
Andrew T, Antoniades L, Scurrah KJ, MacGregor AJ, Spector TD. The risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing bone mineral density. Journal of Bone and Mineral Research. 2005, 20 (1): 67-74. [PDF File]
Spector TD, Conaghan PG, Buckland-Wright JC, Garnero P, Cline GA, Beary JF, Valent DJ, Meyer JM. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomised controlled trial. Arthritis Research & Therapy 2005.; 7 (3): R625-33. [PDF File]
Martin F, Hart DJ, Spector TD, doyle DV, Hararai D. Fear of Falling Limiting Activity in Young-Old Women is Associated with Reduced Functional Mobility rather than Psychological Factors. Age and Ageing 2005 May; 34 (3): 281-7. [PDF File]
Williams FM, Cherkas LF, Spector TD, MacGregor AJ. The effect of moderate alcohol consumption on bone mineral density: a study of female twins. Ann Rheum Dis. Feb 2005; 64(2):309-310. [PDF File]
Reneland RH, Mah S, Kammerer S, Hoyal CR, Marnellos G, Wilson SG, Sambrook PN, Spector TD, Nelson MR, Braun A. Association between a variation in the phosphodiesteraseD gene and bone mineral density. BMC Medical Genetics 2005,Mar 7; 6 (1): 9. [PDF File]
NG MYM, Andrew T, Spector TD, Jeffery S. Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. J Med Genet 2005; 42:235-239 [PDF File]
Dunn KM, Cherkas LF, Spector TD. Genetic influences on variation in female sexual function. A twin study. Biology Letters (The Royal Society) 2005;1 (3): 260-263. [PDF File]
Liew SH, Elsner H, Spector TD, Hammond CJ. The first "Classical" Twin Study? Analysis of refractive error using monozygotic and dizygotic twins published in 1922. Twin Research Hum Genet 2005; Jun 8 (3): 198-200. [PDF File]
Chen Y, Snieder H, Wang X, Kaviya B, McCaffrey C, Spector TD, Carter ND, O'Dell SD. Proopiomelanocortin gene variants are associated with serum leptin and body fat in a normal female population. Eur J Hum Genet. 2005 Jun; 13 (6): 772-80. [PDF File]
Valdes A, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas L, Aviv A, Spector TD. Increased body mass and cigarette smoking are associated with short telomeres in women. The Lancet 2005; 366 (9486): 662-4 [PDF File]
Mohamed I Cherkas LF, Riley SA, Spector TD, Trudgill NJ. Genetic influences in irritable bowel syndrome: a twin study. Am J Gastroenterol. 2005 June; 100 (6): 1340-4. [PDF File]
Singer JJ, MacGregor AJ, Cherkas LF, Spector TD. Where did I leave my keys? A twin study of self-reported memory ratings using the multifactorial memory questionnaire. Twin Res Hum Genet 2005 Apr; 8 (2): 108-12. [PDF File]
Valdes A, Hassett G, Hart DJ, Spector TD. Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes: a candidate SNP association study in the chingford cohort. Spine 2005;30 (21): 2445-2451. [PDF File]
Fraga M, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu Y, Plass C, Esteller M. Epigenetic differences arise during the lifetime of monozygotic twins. PNAS 2005; 102 (30): 10604-9. [PDF File]
2004
Altman RD, Bloch D.A, Dougados M, Hochberg M, Lohmander S, Pavelka K, Spector TD, Vignon E. Measurement of structural progression in osteoarthritis of the hip: the Barcelona consensus group. Osteoarthritis and Cartilage 2004, 12: 515-524. [PDF File]
Spector TD. Strontium Ranelate: the first drug in a new class for osteoporosis. Future Prescriber 2004, 5 (2): 13-16
Spector TD, Ralston SH. Genetic factors in osteoporosis. Medicographia 2004 3 (26): 221-226.
Cherkas LF, Oelsner E, Mak YT, Valdes A, Spector TD. Genetic influences on female infidelity and number of sexual partners in humans: A linkage and association study of the role of the vasopreswsin receptor gene (AVPR1A). Twin Research 2004, 7 (6): 649-58 [PDF File]
de Lange M, Spector TD, Andrew T. Genome-Wide Scan for Blood Pressure Suggests Linkage to Chromosome 11, andReplication of Loci on 16, 17, and 22. Hypertension 2004 Dec;44 (6):872-7 [PDF File]
Williams MK, Cherkas LF, Spector TD, MacGregor AJ. A common genetic factor underlies hypertension and other cardiovascular disorders. BMC Cardiovascular Disorders 2004 Nov 1;4 (1):20 [PDF File]
Spector TD. Osteoporosis - NICE sets new challenges for London. Capital Doctor Sept 2004, 36:22.
Greenfield JR, Samaras K, Jenkins AB, Kelly PJ, Spector TD, and Campbel LV. Do gene-environment interactions influence fasting plasma lipids? A study of twins.Eur J Clin Invest, Sep 1, 2004; 34(9): 590-8.
Hammond CJ, Andrew T, Tat Mak Y, Spector TD. A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins. Am J Hum Genet. Aug 2004; 75(2):294-304. [PDF File]
Hakim AJ, Cherkas LF, Grahame R, Spector TD, MacGregor AJ. The genetic epidemiology of joint hypermobility: a population study of female twins. Arthritis Rheum. Aug 2004; 50(8):2640-4.
Valdes AM, Hart DJ, Jones KA, Surdulescu G, Swarbrick P, Doyle DV, Schafer AJ, Spector TD. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Arthritis Rheum. Aug 2004; 50(8):2497-507. [PDF File]
Dong Y, Zhu H, Wang X, Dalageorgou C, Carter N, Spector TD, Snieder H. Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: a study of female dizygotic twins. Pharmacogenetics Jul 2004; 14(7): 419-427. [PDF File]
Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD, Cannata J, Balogh A, Lemmel EM, Pors-Nielsen S, Rizzoli R, Genant HK, Reginster JY. The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women With Postmenopausal Osteoporosis. Obstet Gynecol Surv. Jul 2004; 59(7):526-527. [PDF File]
Garner C, Silver N, Best S, Menzel S, Martin C, Spector TD, Thein SL. A Quantitative Trait Locus on Chromosome 8q Influences the Switch From Fetal to Adult Hemoglobin. Blood 2004 Oct 1;104 (7):2184-6 [PDF File]
Smith AJ, Keen LJ, Billingham MJ, Perry MJ, Elson CJ, Kirwan JR, Sims JE,Doherty M, Spector TD, Bidwell JL. Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: association with knee osteoarthritis.Genes Immun. Jun 10, 2004. [PDF File]
Greenfield JR, Samaras K, Jenkins AB, Kelly PJ, Spector TD, Gallimore JR, Pepys MB, Campbell LV. Obesity Is an Important Determinant of Baseline Serum C-Reactive Protein Concentration in Monozygotic Twins, Independent of Genetic Influences. Circulation. Jun 2004; 109(24):3022-8
Mak YT, Hampson G, Beresford JD, Spector TD. Variations in genome-wide gene expression in identical twins - a study of primary osteoblast-like culture from female twins discordant for osteoporosis.BMC Genet. Jun 4, 2004. [PDF File]
Knapp KM, Blake GM, Spector TD, Fogelman I. Can the WHO definition of osteoporosis be applied to multi-site axial transmission quantitative ultrasound? Osteoporos Int. May 2004;15(5):367-74.
Spector TD, Selby PL. Strontium ranelate: a new treatment for osteoporosis. Osteoporosis review 2004, 12 (4): 08-10. [PDF File]
Desai Anup V, Cherkas Lynn F, Spector Tim D, Williams Adrian J. Genetic Influences in Self-Reported Symptoms of Obstructive Sleep Apnoea and Restless Legs: A Twin Study. Twin Research 2004; 7(6):589-595.[PDF File]
MacGregor AJ, Andrew T, Sambrook PN, Spector TD. Structural, Psychological, and genetic influences on low back and neck pain: A study of adult female twins. Arthritis Rheum. Apr 15, 2004; 51(2):160-7. [PDF File]
Spector TD, MacGregor AJ. Risk factors for osteoarthritis: Genetics. Osteoarthritis and Cartilage. 2004, 12 Suppl A: S39-44.[PDF File]
Dunn EJ, Ariens RA, De Lange M, Snieder H, Turney JH, Spector TD, Grant PJ. Genetics of fibrin clot structure: A twin study. Blood Mar 1, 2004; 103(5):1735-40 [PDF File]
Van Den Oord EJ, MacGregor AJ, Snieder H, Spector TD. Modeling with measured genotypes: effects of the vitamin d receptor gene, age,and latent genetic and environmental factors on bone mineral density. Behav Genet. Mar 2004; 34(2):197-206. [PDF File]
Wilson SG, Reed PW, Andrew T, Barber MJ, Lindersson M, Langdown M, Thompson D, Thompson E, Bailey M, Chiano M, Kleyn PW, Spector TD. A genome-screen of a large twin cohort reveals linkage for quantitative ultrasound of the calcaneus to 2q33-37 and 4q12-21. J Bone Miner Res. Feb 2004; 19(2):270-7
Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD, Cannata J, Balogh A, Lemmel EM, Pors-Nielsen S, Rizzoli R, Genant HK, Reginster JY. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med. Jan 29, 2004; 350(5):459-68.[PDF File]
MacGregor AJ, Gallimore JR, Spector TD, Pepys MB. Genetic Effects on Baseline Values of C-Reactive Protein and Serum Amyloid A Protein: A Comparison of Monozygotic and Dizygotic. Twins.Clin Chem. Jan 2004; 50(1):130-4
2003
Ahmadi KU, Lanchbury JS, Reed P, Chiano M, Thompson D, Galley M, LineA, Lank E, Wong HJ, Strachan D, Spector TD. Novel association suggest multiple independent QTLs within chromosome 5q21-33 region control variation in total humans IgE levels. Genes Immun 2003; 4 (4): 289-97
Antoniades L, MacGregor AJ, Andrew T, Spector TD. Association of Birth Weight with Osteoporosis and Osteoarthritis in Adult twins.Rheumatology 2003;42(6):791-796 [PDF File]
Dolan AL, Hart DJ, Doyle DV, Grahame R, Spector TD. The relationship of joint hypermobility, bone mineral density and osteoarthritis in the general population: the Chingford Study. Journal of Rheumatology 2003;30(4):799-803
Greenfield JR, Samaras K, Jenkins AB, Kelly PJ, Spector TD, Campbell LV. Moderate alcohol consumption, estrogen replacement therapy, and physical activity are associated with increased insulin sensitivity: Is abdominal adiposity the mediator? Diabetes Care 2003; 26 (10): 2734-2740.[PDF File]
Greenfield JR, Samaras K, Campbell LV, Jenkins AB, Kelly PJ, Spector TD, Hayward CS. Physical activity reduces genetic susceptibility to increased central systolic pressure augmentation: A study of female twins. J Am Coll Cardiol 2003; 42 (2): 264-70.
Hakim AJ, Cherkas LF, Spector TD, MacGregor AJ. Genetic Associations between Frozen Shoulder and Tennis Elbow: A Female Twin Study. Rheumatology 2003;42(6):739-742 [PDF File]
Hart DJ, Spector TD. Kellgren & Lawrence grade 1 osteophytes in the knee -doubtful or definite? Osteo Cartilage 2003 11(2):149-150 [PDF File]
Hunter DJ, Hart DJ, Snieder H, Bettica P, Swaminathan R, Spector TD. Evidence of Altered Bone Turnover, Vitamin D and Calcium Regulation with Knee Osteoarthritis in Female Twins. Rheumatology 2003; 42 (11): 1311-6.
Knapp KM, Andrew T, MacGregor AJ, Blake GM, Fogelman I, Spector TD. An investigation of unique and shared gene effects on speed of sound and bone density using axial transmission quantitative ultrasound and DXA in twins. Journal and Bone and Mineral Research, 2003,18 (8): 1525-1530 [PDF File]
Knapp KM, Blake GM, Spector TD, Fogelman I. Differential effects of hormone replacement therapy on bone mineral density and axial transmission ultrasound measurements in cortical bone. Osteoporosis International 2003; 14 (4): 289-94
Leslie RD, Beyan H, Sawtell P, Boehm BO, Spector TD, Snieder H. Level of an advanced glycated end product is genetically determined. A study of normal twins. Diabetes, 2003, 52: 2441-2444 [PDF File]
Manek NJ, Spector TD, Hart D, MacGregor AJ. The association of body mass index and osteoarthritis of the knee joint: an examination of genetic and environmental influences. Arthritis & Rheumatism 2003,48(4):1024-9 [PDF File]
Mohammed I, Cherkas LF, Riley SA, Spector TD, Trudgill NJ. Genetic influences in gastro-oesophageas reflux disease: A twin study GUT 2003; 52: 1085-1089.
Rijsdijk FV, Snieder H, Ormel J, Sham P, Goldberg DP, Spector TD. Genetic and environmental influences on psychological distress in the population: General Health Questionnaire analyses in UK twins. Psychological Medicine, 2003; 33, 793-801 [PDF File]
Smyth AE, MacGregor AJ, Mukerjee D, Brough GM, Black CM, Denton CP.. A cross-sectional comparison of three self-reported functional indices in scleroderma. Rheumatology 2003; 42:732-738 [PDF File]
Wilson SG, Reed PW, Bansal A, Chiano M, Lindersson M, Langdown M, Prince RL, Thompson D, Thompson E, Bailey M, Kleyn PW, Sambrook P, Shi MM, Spector TD. Comparisons of Genome Screens for two independent cohorts provides replication of suggestive linkage of bone mineral density to 3p21 and 1p36. American Journal of Human genetics, 2003;72:144-155. [PDF File]
Mulder EJ, Van Baal C, Gaist D, Kallela M, Kaprio J, Svensson DA, Nyholt DR, Martin NG, MacGregor AJ, Cherkas LF, Boomsma DI, Palotie A. Genetic and enviromental influences on migraine: a twin study across six countries. Twin Research 2003; 6 (5): 422-431 [PDF File]
Bonjour D, Cherkas L, Haskel J, Hawkes K, Spector T. Retuns to education: Evidence from UK twins. Centre for the Economics of Education 2003 December;93 (5):1799-1812. [PDF File]
2002
Andrew T, Mak YT, Reed P, MacGregor AJ, Spector TD. Association of Heel Ultrasound Measurements, Bone Mineral Density and Bone Turnover Markers with the Osteocalcin Gene in Female Dizygotic Twins. Osteoporosis International 2002 Sep;13(9):745-54 [PDF File]
Arden NK, Major P, Poole JR, Keen RW, Vaja S, Swaminathan R, Cooper C, Spector TD. Size at birth, adult intestinal calcium absorption and 1,25(OH)(2) vitamin D. QJM 2002 Jan;95(1):15-21 [PDF File]
Ariens RA, de Lange M, Snieder H, Boothby M, Spector TD, Grant PJ. Activation markers of coagulation and fibrinolysis in twins: Heritability of the prethrombotic state. Lancet 2002 Feb 23;359(9307):667-71 [PDF File]
Bettica, Cline, Hart, Meyer, Spector. Evidence for Increased Bone Resorption in Patients with Progressive Knee OA: Longitudinal Results from the Chingford Study. Arthritis & Rheumatism 2002 Dec;46(12):3178-84 [PDF File]
Chan LYS, Lam CW, Mak YT, Tomlinson B, Tsang MW, Baum L, Masarei JRL and Pang CP. Genotype-phenotype studies of six novel LPL mutations in Chinese patients with hypertriglyceridemia. Hum Mutation, 2002; 20:232-3.
Edwards CJ, Spector TD. Statins as modulators of bone formation. Arthritis Research 2002;4(3):151-3 [PDF File]
Gillaspy, Spreckley, Doherty, Spector, Wallis. Investigation of linkage between chromosome 2q and osteoarthritis. Arthritis Rheum 2002 Dec;46(12):3386-7 [PDF File]
Hakim A, Cherkas L, El Zayat S, MacGregor AJ, Spector TD. The genetic contribution to carpal tunnel syndrome in women: A twin study. Arthritis & Rheumatism 2002 Jun 15;47(3):275-9 [PDF File]
Hammond CJ, Webster AR, Snieder H, Bird AC, Gilbert CE, Spector TD. Genetic influence on early age-related maculopathy: A twin study. Ophthalmology. 2002 Apr;109(4):730-736 [PDF File]
Hart D J, Cronin C, Daniels M, Worthy T, Doyle DV, Spector TD. The relationship of bone density and fracture to incident and progressive radiographic knee osteoarthritis: The Chingford Study. Arthritis & Rheumatism 2002;46: 92-99 [PDF File]
Hunter, de Lange, Snieder, MacGregor, Swaminathan, Thakker, Spector. Genetic contribution of renal function and electrolyte balance: a twin study. Clinical Science 2002 Sep 1;103(3):259-65 [PDF File]
Kawano, Ogata, Chiano, Molloy, Kleyn, Spector, Uchida, Hosoi, Suzuki, Orimo, Inoue, Nabeshima, Nakamura, Kuro-o, Kawaguchi. Klotho Gene Polymorphisms Associated with Bone Density of Aged Postmenopausal Women. Journal of Bone and Mineral Research 2002 Oct;17(10):1744-51 [PDF File]
Knapp KM, Blake GM, Fogelman I, Doyle DV, Spector TD. Multisite Quantitative Ultrasound: Colles' Fracture Discrimination in Postmenopausal Women. Osteoporosis International 2002;13(6):474-9 [PDF File]
Lee RL, Dacre JE, Hart DJ, Spector TD. Femoral neck trabecular patterns predict osteoporotic fractures. Med Phys. 2002 Jul;29(7):1391-6
Middelberg RP, Spector TD, Swaminathan R, Snieder H. Genetic and environmental influences on lipids, lipoproteins and apolipoproteins: effects of menopause. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1142-7 [PDF File]
Naganathan V, MacGregor AJ, Snieder H, Nguyen T, Spector T, Sambrook P. Gender differences in the genetic influences on bone density and bone quality. Journal of Bone Mineral Research J Bone Miner Res 2002 Apr;17(4):725-33 [PDF File]
Spector, MacGregor. The St Thomas' UK Adult Twin Registry. Twin Research 2002;5(5):440-443 [PDF File]
2001
Ahmadi KR, Hall MA, Norman P, Vaughan RW, Snieder H, Spector TD, Lanchbury JS. Genetic determinism in the relationship between human CD4 (+) and CD8 (+) T lymphocyte populations? Genes Immun 2001;2(7):381-7.
Andrew T, Hart DJ, Snieder H, de Lange M, Spector TD, MacGregor AJ. Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Research 2001 Dec;4(6):464-77 [PDF File]
Antoniades L, Spector TD, MacGregor AJ. The genetic contribution to hip joint morphometry and relationship to hip cartilage thickness. Osteoarthritis Cartilage 2001;9(6):593-5. [PDF File]
Baird J, Osmond C, MacGregor A, Snieder H, Hales CN, Phillips DIW. Testing the tetal origins hypothesis in twins: the Birmingham twin study. Diabetologia 2001;44:33-39 [PubMed].
Bataille V, Snieder H, MacGregor AJ, Sasieni P, Spector TD. The influence of genetics and environmental factors in the pathogenesis of acne: A twin study of acne in women. J Invest Dermatol. 2002 Dec;119(6):1317-22[PDF File]
Cherkas LF, Howell K, Carter L, Black CM, MacGregor AJ The use of portable radiometry to assess Raynaud's phenomenon: a practical alternative to thermal imaging. Rheumatology (Oxford)2001 Dec;40 (12):1384-7 [PDF File]
Czarny-Ratajczak M, Lohiniva J, Rogala P, Kozlowski K, Perala M, Carter L, Spector TD, Kolodziej L, Seppanen U, Glazar R, et al. A mutation in col9a1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity. Am J Hum Genet 2001;69(5):969-80. [PDF File]
de Lange M, Snieder H, Ariens RA, Spector TD, Grant PJ. The genetics of haemostasis: A twin study. Lancet 2001;357(9250):101-105. [PDF File]
Dennison EM, Arden NK, Keen RW, Syddall H, Day IN, Spector TD, Cooper C. Birthweight, vitamin D receptor genotype and the programming of osteoporosis. Paediatric & Perinatal Epidemiology 2001 Jul;15(3):207 [PDF File]
Drake WM, Rodriguez-Arnao J, Weaver JU, James IT, Coyte D, Spector TD, Besser GM, Monson JP. The influence of gender on the short and long-term effects of growth hormonal replacement on bone metabolism and bone mineral density in hypopituitar adults: a 5-year study. Clin Endocrinol (Oxf). 2001;54 (4):525-532. [PDF File]
Drayna D, Manichaikul A, de Lange M, Snieder H, Spector TD. Genetic correlates of musical pitch recognition in humans. Science 2001;291:1969-72 [PDF File]
Edwards CJ, Russell RG, Spector TD. Statins and bone: myth or reality? Calcif Tissue Int 2001;69(2):63-6. [PDF File]
Hammond CJ, Duncan DD, Snieder H, de Lange M, West SK, Spector TD, Gilbert CE. The heritability of age-related cortical cataract: The twin eye study. Invest. Ophthalmol. Vis. Sci. 200142(3):601-605. [PDF File]
Hammond CJ, Snieder H, Gilbert CE, Spector TD. Genes and environment in refractive error: the twin eye study. Invest Ophthalmol Vis Sci. 2001; 42 (6):1232-1236. [PDF File]
Hunter D, de Lange M, Snieder H, MacGregor AJ, Swaminathan R, Thakker RV, Spector TD. Genetic contribution to bone metabolism, calcium excretion and vitamin D and parathyroid hormone regulation Journal of Bone and Mineral Research 2001;16(2):371-378. [PDF File]
Hunter DJ, de Lange M, Andrew T, Snieder H, MacGregor AJ, Spector TD. Genetic Variation in Bone Mineral Density (BMD) and Calcaneal Ultrasound: A Study of the Influence of Menopause using Female Twins. Osteoporosis International 2001;12(5):406-11.[PDF File]
Jenkins AB, Samaras K, Gordon MS, Snieder H, Spector TD, Campbell LV. Lack of heritability of circulating leptin concentration in humans after adjustment for body size and adiposity using a psychological approach. Int J Obes Relat Metab Disord 2001 Nov;25(11):1625-32
Keen RW, Snieder H, Molloy H, Daniels J, Chiano M, Gibson F, Fairbairn L, Smith P, MacGregor AJ, Gewert D, Spector TD. Evidence of association and linkage disequilibrium between a novel polymorphism in the transforming growth factor b1 gene and hip bone mineral density: a study of female twins. Rheumatology 2001;40:48-54 [PDF File]
Knapp KM, Blake GM, Spector TD, Fogelman I. Multisite quantative ultrasound: precision, age- and menopause-related changes, fracture discrimination, and T-score equivalence with dual-enery X-ray absorptiometry. Osteoporosis International 2001; 12 (6): 456-464.
Millard TP, Antoniades L, Evans AV, Smith HR, Spector TD, Barker JN. Bone mineral density of patients with chronic plaque psoriasis. Clin Exp Dermatol 2001;26(5):446-8. [PDF File]
Snieder H, Sawtell PA, Ross L, Walker J, Spector TD, Leslie RD. HbA(1c) Levels Are Genetically Determined Even in Type 1 Diabetes: Evidence From Healthy and Diabetic Twins. Diabetes 2001;50(12):2858-63. [PDF File]
Snieder H, van den Oord EJC, Chiano M, MacGregor AJ, Spector TD. Sib-TDT analysis of human TGF-beta1 gene single nucleotide polymorphisms in female twins: evidence for linkage and association with blood pressure at the codon 263 polymorphism. Genescreen. 2001; 1(2): 89-92
Strachan DP, Wong HJ, Spector TD. Concordance and interrelationship of atopic diseases and markers of allergic sensitization among adult emale twins. J Allergy Clin Immunol 2001;108(6):901-7.
Vickers MA, McLeod E, Spector TD, Wilson IJ. Assessment of mechanism of acquired skewed X inactivation by analysis of twins. Blood 2001;97(5):1274-1281. [PDF File]
Vignon E, Garnero P, Delmas P, Avouac B, Bettica P, Boers M, Ehrich E, MacKillop N, Rovati L, Serni U, Spector TD, Reginster JY. Recommendations for the registration of drugs used in the treatment of osteoarthritis: an update on biochemical markers. Osteoarthritis & Cartilage 2001;9, 289-293
White KE, Jonsson KB, Carn G, Hampson G, Spector TD, Mannstadt M, Lorenz-Depiereux B, Miyauchi A, Yang IM, Ljunggren O, Meitinger T, Strom TM, Juppner H, Econs MJ. The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting. Journal of Clinical Endocrinology & Metabolism 2001;86(2):497-500. [PDF File]
2000
Alavi A, Arden N, Spector TD, Axford JS. Immunoglobulin G glycosylation and clinical outcome in rheumatoid arthritis during pregnancy. J Rheumatol 2000;27(6):1379-85.
Andrew T, Moriarty J, Levin E, Webb S. Outcome of referral to social services departments for people with cognitive impairment. Int. J. Geriat. Psychiatry 2000;15:406-414.
Antoniades L, MacGregor AJ, Matson M, Spector TD. A co-twin control study of the relationship between hip osteoarthritis and bone mineral density. Arthritis & Rheumatism 2000;43(7):1450-5. [PDF File]
Bataille V, Snieder H, MacGregor A, Spector T. Hereditary factors in basal cell carcinoma of the skin: a population-based cohort study in twins [letter; comment]. Br J Cancer 2000;82(1):247-9. [PDF File]
Bataille V, Snieder H, MacGregor AJ, Sasieni P, Spector TD. Genetics of risk factors for melanoma: an adult twin study of nevi and freckles. J Natl Cancer Inst 2000;92(6):457-63. [PDF File]
Carter N, Snieder H, Jeffery S, Saumarez R, Varma C, Antoniades L, Spector TD. QT interval in twins. J Hum Hypertens 2000;14(6):389-90.
Chan L, Mak Y, Tomlinson B, Baum L, Wu X, Masarei J and Pang C. Compound heterozygosity of Leu252Val and Leu252Arg causing lipoprotein lipase deficiency in a Chinese patient with hypertriglyceridemia. Eur J Clin Invest, 2000; 30:33-40.
Cherkas L, Hochberg F, MacGregor AJ, Snieder H, Spector TD. Happy families: a twin study of humour. Twin Res 2000;3(1):17-22. [PDF File]
Doherty M, Spector TD, Serni U. Epidemiology and genetics of hand osteoarthritis. Osteoarthritis Cartilage. 2000;Suppl A:S14-S15.
Edwards CJ, Hart DJ, Spector TD. Oral Statins and increased bone mineral density in postmenopausal women. Lancet 2000;355(9222):2218-9. [PDF File]
Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, JOrdan JM, Kington RS, Lane NE, Nevitt MC, Zhang Y, Soweres M, McAlindon T, Spector TD, Poole AR, Yanovski SZ, Ateshian G, Sharma L, Buckwalter JA, Brandt K, Fries JF. Osteoarthritis - New insights. Part 1: The disease and its risk factors. Annals of Internal Medicine 2000;133(8):635-46. [PDF File]
Garner C, Tatu T, Carne L, Cardon L, Spector TD, Farrall M, Thein SL. A candidate gene study of F cell levels in sibling pairs using a joint linkage and association analysis. GeneScreen 2000;1:9-14. [PDF File]
Garner C, Tatu T, Reittie JE, Littlewood T, Darley J, Cervino S, Farrall M, Kelly P, Spector TD, Thein SL. Genetic influences on F cells and other hematologic variables: a twin heritability study. Blood 2000;95(1):342-6. [PDF File]
Hall MA, Ahmadi KR, Norman P, Snieder H, MacGregor AJ, Vaughan RW, Spector TD, Lanchbury JS. Genetic influence on peripheral blood T lymphocyte levels. Genes and immunity 2000;1:423-427. [PDF File]
Hammond CJ, Snieder H, Spector TD, Gilbert CE. Genetic and environmental factors in age-related nuclear cataracts in monozygotic and dizygotic twins. N Engl J Med 2000;342(24):1786-90. [PDF File]
Hammond CJ, Snieder H, Spector TD, Gilbert CE. Factors affecting pupil size after dilatation: the twin eye study. British Journal of Ophthalmology 2000;84:1173-1176. [PDF File]
Hunter D, Major P, Arden N, Swaminathan R, Andrew T, MacGregor AJ, Keen R, Snieder H, Spector TD. A randomized controlled trial of vitamin D supplementation on preventing bone loss and modifying bone metabolism using identical twin pairs. J Bone Miner Res 2000;15(11):2276-83 [PubMed].
Lam CW, Mak YT, Lo YMD, Tong SF, To KF, Lai FMM. Molecular genetic analysis of a Chinese patient with Fabry disease. Chin Med J, 2000; 113:186-188.
Lloyd ME, Spector TD, Howard R. Osteoporosis in neurological disorders [In Process Citation]. J Neurol Neurosurg Psychiatry 2000;68(5):543-7. [PDF File]
MacGregor AJ, Snieder H, Schork NJ, Spector TD. Twins. Novel uses to study complex traits and genetic diseases. Trends Genet 2000;16(3):131-4. [PDF File]
MacGregor AJ, Snieder H, Spector TD. Genetic factors and osteoporotic fractures in elderly people. BMJ 2000;320:1669-70.
MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, Silman AJ. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 2000;43(1):30-7. [PDF File]
MacGregor AJ, Antoniades L, Matson M, Andrew T, Spector TD. The genetic contribution to radiographic hip osteoarthritis in women: results of a classic twin study. Arthritis & Rheumatism 2000;43(11):2410-2416. [PDF File]
Millard TP, Bataille V, Snieder H, Spector TD, McGregor JM. The Heritability of polymorphic light eruption. JID 2000;115(3):467-70. [PDF File]
Snieder H, Hayward CS, Perks U, Kelly RP, Kelly PJ, Spector TD. Heritability of central systolic pressure augmentation: a twin study. Hypertension 2000;35(2):574-9. [PDF File]
Spector TD. Osteoporosis: Genetics, prevention and treatment. New England Journal of Medicine 2000;342(22);1683.
Susol E, MacGregor AJ, Barrett JH, Wilson H, Black C, Welsh K, Silman A, Ollier B, Worthington J. A two-stage, genome-wide screen for susceptibility loci in primary Raynaud's phenomenon. Arthritis & Rheumatism 2000;43(7):1641-6.
Swaminathan R, Major P, Snieder H, Spector TD. Serum creatinine and fat free mass (lean body mass). Clin Chem 2000; 46 (10): 1695-6. [PDF File]
Wluka AE, Cicuttini FM, Spector TD. Menopause, Oestrogens and Arthritis. Maturitas 2000;35(3):183-99. [PDF File]
1999
Etherington J, Keeling J, Bramley R, Swaminathan R, McCurdie I, Spector TD. The effects of 10 weeks military training on heel ultrasound and bone turnover. Calcif Tissue Int 1999;64(5):389-93. [PDF File]
George GH, MacGregor AJ, Spector TD. Influence of current and past hormone replacement therapy on bone mineral density: a study of discordant postmenopausal twins. Osteoporos Int 1999;9(2):158-62. [PDF File]
Grainger DJ, Percival J, Chiano M, Spector TD. The role of serum TGF-beta isoforms as potential markers of osteoporosis. Osteoporos Int 1999;9(5):398-404. [PDF File]
Grainger DJ, Heathcote K, Chiano M, Snieder H, Kemp PR, Metcalfe JC, Carter ND, Spector TD. Genetic control of the circulating concentration of transforming growth factor type beta1. Hum Mol Genet 1999;8(1):93-7. [PDF File]
Hart DJ, Doyle DV, Spector TD. Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. Arthritis Rheum 1999;42(1):17-24. [PDF File]
Kanis JA, McCloskey EV, Powles T, Paterson AH, Ashley S, Spector T. A high incidence of vertebral fracture in women with breast cancer. Br J Cancer 1999;79(7-8):1179-81. [PDF File]
Keen RW, Woodford-Richens KL, Grant SF, Ralston SH, Lanchbury JS, Spector TD. Association of polymorphism at the type I collagen (COL1A1) locus with reduced bone mineral density, increased fracture risk, and increased collagen turnover. Arthritis Rheum 1999;42(2):285-90. [PDF File]
Keen RW, Hart DJ, Arden NK, Doyle DV, Spector TD. Family history of appendicular fracture and risk of osteoporosis: a population-based study. Osteoporos Int 1999;10(2):161-6. [PDF File]
Lloyd ME, Hunt S, Spector TD. Imaging of pelvic fracture in a patient with psoriatic arthritis [letter]. Rheumatology (Oxford) 1999;38(9):902-4. [PDF File]
Macdonald A, Chatrath P, Spector T, Ellis H. Level of termination of he spinal cord and the dural sac: a magnetic resonance study. Clin Anat 1999;12(3):149-52 [PubMed].
MacGregor AJ, Spector TD. Twins and the genetic architecture of osteoarthritis [editorial]. Rheumatology (Oxford) 1999;38(7):583-8 [PubMed].
Poulter NR, Chang CL, MacGregor AJ, Snieder H, Spector TD. Association between birth weight and adult blood pressure in twins: historical cohort study [see comments]. BMJ 1999;319(7221):1330-3 [PubMed].
Samaras K, Kelly PJ, Chiano MN, Spector TD, Campbell LV. Genetic and environmental influences on total-body and central abdominal fat: the effect of physical activity in female twins [see comments]. Ann Intern Med 1999;130(11):873-82. [PDF File]
Sambrook PN, MacGregor AJ, Spector TD. Genetic influences on cervical and lumbar disc degeneration: a magnetic resonance imaging study in twins. Arthritis Rheum 1999;42(2):366-72. [PDF File]
Snieder H, Boomsma DI, van Doornen LJ, Neale MC. Bivariate genetic analysis of fasting insulin and glucose levels. Genet Epidemiol 1999;16(4):426-46.
Snieder H, van Doornen LJ, Boomsma DI. Dissecting the genetic architecture of lipids, lipoproteins, and apolipoproteins: lessons from twin studies. Arterioscler Thromb Vasc Biol 1999;19(12):2826-34 [PubMed].
Snieder H, Hayward CS, Perks U, Kelly RP, Kely PJ, Spector TD. Heritability of central systolic pressure augmentation. A twin study. Hypertension 1999. [PDF File]
Spector TD, Snieder H, Keen R, Lewis C, MacGregor A. Interpreting the results of a segregation analysis of generalized radiographic osteoarthritis: comment on the article by Felson et al [letter; comment]. Arthritis Rheum 1999;42(5):1068-70.
1998
Boomsma DI, Snieder H, de Geus EJ, van Doornen LJ. Heritability of blood pressure increases during mental stress. Twin Res 1998;1(1):15-24.
Cicuttini FM, Baker J, Hart DJ, Spector TD. Relation between Heberden's nodes and distal interphalangeal joint osteophytes and their role as markers of generalised disease. Ann Rheum Dis 1998;57(4):246-8. [PDF File]
Dolan AL, Arden NK, Grahame R, Spector TD. Assessment of bone in Ehlers Danlos syndrome by ultrasound and densitometry. Ann Rheum Dis 1998;57(10):630-3. [PDF File]
Havenaar EC, Axford JS, Brinkman-van der Linden EC, Alavi A, Van Ommen EC, Van Het Hof B, Spector TD, Mackiewicz A, Van Dijk W. Severe rheumatoid arthritis predicts the pregnacy-induced clearease in Alpha3- Tycosylation of AlphaL-Acid Glycoprotein. Glycoconj. J 1998; 15(7): 723-729.
Hoffer MJ, Bredie SJ, Snieder H, Reymer PW, Demacker PN, Havekes LM, Boomsma DI, Stalenhoef AF, Frants RR, Kastelein JJ. Gender-related association between the -93T-->G/D9N haplotype of the lipoprotein lipase gene and elevated lipid levels in familial combined hyperlipidemia. Atherosclerosis 1998;138(1):91-9.
Keen RW, Woodford-Richens KL, Lanchbury JS, Spector TD. Allelic variation at the interleukin-1 receptor antagonist gene is associated with early postmenopausal bone loss at the spine. Bone 1998;23(4):367-71. [PDF File]
Masud T, Mulcahy B, Thompson AV, Donnelly S, Keen RW, Doyle DV, Spector TD. Effects of cyclical etidronate combined with calcitriol versus cyclical etidronate alone on spine and femoral neck bone mineral density in postmenopausal osteoporotic women. Ann Rheum Dis 1998;57(6):346-9. [PDF File]
Rigby AS, MacGregor AJ, Thomson G. HLA haplotype sharing in rheumatoid arthritis sibships: risk estimates subdivided by proband genotype. Genet Epidemiol 1998;15(4):403-18.
Samaras K, Kelly PJ, Spector TD, Chiano MN, Campbell LV. Tobacco smoking and oestrogen replacement are associated with lower total and central fat in monozygotic twins. Int J Obes Relat Metab Disord 1998;22(2):149-56.
Samaras K, Kelly PJ, Chiano MN, Arden N, Spector TD, Campbell LV. Genes versus environment. The relationship between dietary fat and total and central abdominal fat. Diabetes Care 1998;21(12):2069-76. [PDF File]
Snieder H, MacGregor AJ, Spector TD. Genes control the cessation of a woman's reproductive life: a twin study of hysterectomy and age at menopause. J Clin Endocrinol Metab 1998;83(6):1875-80 . [PDF File]
Swale VJ, Spector TD, Bataille VA. Sarcoidosis in monozygotic twins [letter]. Br J Dermatol 1998;139(2):350-2.
1997
van Doornen LJ, Snieder H, Boomsma DI. Serum lipids and cardiovascular reactivity to stress. Biol Psychol 1998;47(3):279-97.
Arden NK, Spector TD. Genetic influences on muscle strength, lean body mass, and bone mineral density: a twin study. J Bone Miner Res 1997;12(12):2076-81. [PDF File]
Brown MA, Kennedy LG, MacGregor AJ, Darke C, Duncan E, Shatford JL, Taylor A, Calin A, Wordsworth P. Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment [see comments]. Arthritis Rheum 1997;40(10):1823-8.
Cicuttini FM, Spector TD. What is the evidence that osteoarthritis is genetically determined? Baillieres Clin Rheumatol 1997;11(4):657-69.
Keen RW, Egger P, Fall C, Major PJ, Lanchbury JS, Spector TD, Cooper C. Polymorphisms of the vitamin D receptor, infant growth, and adult bone mass. Calcif Tissue Int 1997;60(3):233-5. [PDF File]
Keen RW, Samaras K, Richens KL, Spector TD, Campbell LV, Kelly PJ. Beta 3-adrenergic receptor gene polymorphisms and determination of adiposity and fat distribution in normal female twins [letter]. Diabetologia 1997;40(1):122-3.
Keen RW, Hart DJ, Lanchbury JS, Spector TD. Association of early osteoarthritis of the knee with a Taq I polymorphism of the vitamin D receptor gene. Arthritis Rheum 1997;40(8):1444-9. [PDF File]
MacGregor AJ, Griffiths GO, Baker J, Spector TD. Determinants of pressure pain threshold in adult twins: evidence that shared environmental influences predominate. Pain 1997;73(2):253-7. [PDF File]
Samaras K, Spector TD, Nguyen TV, Baan K, Campbell LV, Kelly PJ. Independent genetic factors determine the amount and distribution of fat in women after the menopause. J Clin Endocrinol Metab 1997;82(3):781-5. [PDF File]
Snieder H, Boomsma DI, van Doornen LJ, de Geus EJ. Heritability of respiratory sinus arrhythmia: dependency on task and respiration rate. Psychophysiology 1997;34(3):317-28.
Snieder H, van Doornen LJ, Boomsma DI. The age dependency of gene expression for plasma lipids, lipoproteins, and apolipoproteins. Am J Hum Genet 1997;60(3):638-50.
Spector TD, Hart DJ, Nandra D, Doyle DV, Mackillop N, Gallimore JR, Pepys MB. Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum 1997;40(4):723-7. [PDF File]
Spector TD, Nandra D, Hart DJ, Doyle DV. Is hormone replacement therapy protective for hand and knee osteoarthritis in women?: The Chingford Study. Ann Rheum Dis 1997;56(7):432-4. [PDF File]
Vogler GP, McClearn GE, Snieder H, Boomsma DI, Palmer R, de Knijff P, Slagboom PE. Genetics and behavioral medicine: risk factors for cardiovascular disease [see comments]. Behav Med 1997;22(4):141-9.
1996
Arden NK, Baker J, Hogg C, Baan K, Spector TD. The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res 1996;11(4):530-4. [PDF File]
Arden NK, Keen RW, Lanchbury JS, Spector TD. Polymorphisms of the vitamin D receptor gene do not predict quantitative ultrasound of the calcaneus or hip axis length. Osteoporos Int 1996;6(4):334-7. [PDF File]
Arden NK, Griffiths GO, Hart DJ, Doyle DV, Spector TD. The association between osteoarthritis and osteoporotic fracture: the Chingford Study. Br J Rheumatol 1996;35(12):1299-304. [PDF File]
Bendall KE, Macaulay VA, Baker JR, Sykes BC. Heteroplasmic point mutations in the human mtDNA control region. Am J Hum Genet 1996;59(6):1276-87.
Cicuttini FM, Baker J, Hart DJ, Spector TD. Association of pain with radiological changes in different compartments and views of the knee joint. Osteoarthritis Cartilage 1996;4(2):143-7. [PDF File]
Cicuttini FM, Baker JR, Spector TD. The association of obesity with osteoarthritis of the hand and knee in women: a twin study. J Rheumatol 1996;23(7):1221-6. [PDF File]
Cicuttini FM, Spector TD. Genetics of osteoarthritis. Ann Rheum Dis 1996;55(9):665-7.
Cicuttini FM, Baker J, Hart DJ, Spector TD. Choosing the best method for radiological assessment of patellofemoral osteoarthritis. Ann Rheum Dis 1996;55(2):134-6.
Cicuttini FM, Spector TD. The genetics of osteoarthritis [editorial]. J Clin Pathol 1996;49(8):617-9 [PubMed].
Cooper C, Egger P, Coggon D, Hart DJ, Masud T, Cicuttini F, Doyle DV, Spector TD. Generalized osteoarthritis in women: pattern of joint involvement and approaches to definition for epidemiological studies. J Rheumatol 1996;23(11):1938-42. [PDF File].
Donnelly S, Hart DJ, Doyle DV, Spector TD. Spiking of the tibial tubercles--a radiological feature of osteoarthritis? Ann Rheum Dis 1996;55(2):105-8. [PDF File]
Etherington J, Harris PA, Nandra D, Hart DJ, Wolman RL, Doyle DV, Spector TD. The effect of weight-bearing exercise on bone mineral density: a study of female ex-elite athletes and the general population. J Bone Miner Res 1996;11(9):1333-8. [PDF File]
Garnero P, Arden NK, Griffiths G, Delmas PD, Spector TD. Genetic influence on bone turnover in postmenopausal twins. J Clin Endocrinol Metab 1996;81(1):140-6. [PDF File]
Hall GM, Larbre JP, Spector TD, Perry LA, Da Silva JA. A randomized trial of testosterone therapy in males with rheumatoid arthritis. Br J Rheumatol 1996;35(6):568-73. [PDF File]
Jawaheer D, MacGregor AJ, Gregersen PK, Silman AJ, Ollier WE. Unexpected HLA haplotype sharing in dizygotic twin pairs discordant for rheumatoid arthritis. J Med Genet 1996;33(12):1015-8.
Keen RW, Spector TD. Role and evolution of therapeutic options. Osteoporos Int 1996;6 Suppl 2:16-20. [PDF File]
Keen RW, Spector TD. Alendronate: a new bisphosphonate for the treatment of osteoporosis. Br J Clin Pract 1996;50(4):211-7.
Keen RW, Griffiths GO, Spector TD. Patients who have had fractures of the distal forearm do not lose bone as expected [letter]. BMJ 1996;313(7060):821.
Keen RW, Nguyen T, Sobnack R, Perry LA, Thompson PW, Spector TD. Can biochemical markers predict bone loss at the hip and spine?: a 4-year prospective study of 141 early postmenopausal women. Osteoporos Int 1996;6(5):399-406. [PDF File]
Lloyd ME, Hart DJ, Nandra D, McAlindon TE, Wheeler M, Doyle DV, Spector TD. Relation between insulin-like growth factor-I concentrations, osteoarthritis, bone density, and fractures in the general population: the Chingford study. Ann Rheum Dis 1996;55(12):870-4. [PDF File]
Masud T, Mootoosamy I, McCloskey EV, O'Sullivan MP, Whitby EP, King D, Matson MB, Doyle DV, Spector TD. Assessment of osteopenia from spine radiographs using two different methods: the Chingford Study. Br J Radiol 1996;69(821):451-6. [PDF File]
O'Neill TW, Grazio S, Spector TD, Silman AJ. Geometric measurements of the proximal femur in UK women: secular increase between the late 1950s and early 1990s. Osteoporos Int 1996;6(2):136-40. [PDF File]
Silman AJ, Newman J, MacGregor AJ. Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins [see comments]. Arthritis Rheum 1996;39(5):732-5 [PubMed].
Spector TD, Hart DJ. [Radiological evaluation of osteoarthritis]. Rev Prat 1996;46(19 Spec No):S15-S21 [PubMed].
Spector TD, Cicuttini F, Baker J, Loughlin J, Hart D. Genetic influences on osteoarthritis in women: a twin study [see comments]. BMJ 1996;312(7036):940-3 [PubMed].
Spector TD, Harris PA, Hart DJ, Cicuttini FM, Nandra D, Etherington J, Wolman RL, Doyle DV. Risk of osteoarthritis associated with long-term weight-bearing sports: a radiologic survey of the hips and knees in female ex-athletes and population controls. Arthritis Rheum 1996;39(6):988-95. [PDF File]
1995
Cicuttini FM, Spector TD. The epidemiology of osteoarthritis of the hand [see comments]. Rev Rhum Engl Ed 1995;62(6 Suppl 1):3S-8S.
Cicuttini FM, Spector TD. Osteoarthritis in the aged. Epidemiological issues and optimal management. Drugs Aging 1995;6(5):409-20.
Egger P, Cooper C, Hart DJ, Doyle DV, Coggon D, Spector TD. Patterns of joint involvement in osteoarthritis of the hand: the Chingford Study. J Rheumatol 1995;22(8):1509-13.
Etherington J, Spector TD. Asymmetrical nodular osteoarthritis in a patient with a hemiparesis [letter] [see comments]. Ann Rheum Dis 1995;54(11):936-7.
Hall GM, Spector TD, Delmas PD. Markers of bone metabolism in postmenopausal women with rheumatoid arthritis. Effects of corticosteroids and hormone replacement therapy. Arthritis Rheum 1995;38(7):902-6. [PDF File]
Hart DJ, Spector TD. Radiographic criteria for epidemiologic studies of osteoarthritis. J Rheumatol Suppl 1995;43:46-8. [PDF File]
Hart DJ, Doyle DV, Spector TD. Association between metabolic factors and knee osteoarthritis in women: the Chingford Study. J Rheumatol 1995;22(6):1118-23. [PDF File]
Hart DJ, Spector TD. The classification and assessment of osteoarthritis. Baillieres Clin Rheumatol 1995;9(2):407-32.
Keen RW, Major PJ, Lanchbury JS, Spector TD. Vitamin-D-receptor-gene polymorphism and bone loss [letter; comment]. Lancet 1995;345(8955):990.
MacGregor AJ, Bamber S, Carthy D, Vencovsky J, Mageed RA, Ollier WE, Silman AJ. Heterogeneity of disease phenotype in monozygotic twins concordant for rheumatoid arthritis. Br J Rheumatol 1995;34(3):215-20.
MacGregor AJ. Classification criteria for rheumatoid arthritis. Baillieres Clin Rheumatol 1995;9(2):287-304.
MacGregor AJ, Ollier WE, Venkovsky J, Mageed RA, Carthy D, Silman AJ. Rheumatoid factor isotypes in monozygotic and dizygotic twins discordant for rheumatoid arthritis. J Rheumatol 1995;22(12):2203-7 .
Masud T, Jawed S, Doyle DV, Spector TD. A population study of the screening potential of assessment of trabecular pattern of the femoral neck (Singh index): the Chingford Study. Br J Radiol 1995;68(808):389-93. [PDF File]
Sambrook PN, Spector TD, Seeman E, Bellamy N, Buchanan RR, Duffy DL, Martin NG, Prince R, Owen E, Silman AJ. Osteoporosis in rheumatoid arthritis. A monozygotic co-twin control study. Arthritis Rheum 1995;38(6):806-9. [PDF File]
Spector TD, Keen RW, Arden NK, Morrison NA, Major PJ, Nguyen TV, Kelly PJ, Baker JR, Sambrook PN, Lanchbury JS. Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain [see comments]. BMJ 1995;310(6991):1357-60. [PDF File]
1994
Arden NK, Lloyd ME, Spector TD, Hughes GR. Safety of hormone replacement therapy (HRT) in systemic lupus erythematosus (SLE). Lupus 1994;3(1):11-3. [PDF File]
Bansal AS, MacGregor AJ, Pumphrey RS, Silman AJ, Ollier WE, Wilson PB. Increased levels of sCD23 in rheumatoid arthritis are related to disease status. Clin Exp Rheumatol 1994;12(3):281-5.
Donnelly S, Doyle DV, Denton A, Rolfe I, McCloskey EV, Spector TD. Bone mineral density and vertebral compression fracture rates in ankylosing spondylitis. Ann Rheum Dis 1994;53(2):117-21. [PDF File]
Hajeer AH, MacGregor AJ, Rigby AS, Ollier WE, Carthy D, Silman AJ. Influence of previous exposure to human parvovirus B19 infection in explaining susceptibility to rheumatoid arthritis: an analysis of disease discordant twin pairs. Ann Rheum Dis 1994;53(2):137-9.
Hall GM, Daniels M, Doyle DV, Spector TD. Effect of hormone replacement therapy on bone mass in rheumatoid arthritis patients treated with and without steroids. Arthritis Rheum 1994;37(10):1499-505. [PDF File]
Hall GM, Daniels M, Huskisson EC, Spector TD. A randomised controlled trial of the effect of hormone replacement therapy on disease activity in postmenopausal rheumatoid arthritis. Ann Rheum Dis 1994;53(2):112-6. [PDF File]
Hart DJ, Mootoosamy I, Doyle DV, Spector TD. The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study. Ann Rheum Dis 1994;53(3):158-62. [PDF File]
Hart DJ, Spector TD, Egger P, Coggon D, Cooper C. Defining osteoarthritis of the hand for epidemiological studies: The chingford study. Annals of Rheumatic Diseases 1994;53:220-223. [PDF File]
Jawaheer D, Thomson W, MacGregor AJ, Carthy D, Davidson J, Dyer PA, Silman AJ, Ollier WE. Homozygosity for the HLA-DR shared epitope contributes the highest risk for rheumatoid arthritis concordance in identical twins. Arthritis Rheum 1994;37(5):681-6.
MacGregor AJ, Bamber S, Silman AJ. A comparison of the performance of different methods of disease classification for rheumatoid arthritis. Results of an analysis from a nationwide twin study. J Rheumatol 1994;21(8):1420-6.
MacGregor AJ, Isenberg DA. Association of steroid treatment and anticardiolipin antibodies with atherosclerosis in systemic lupus erythematosus: comment on the article by Lahita et al [letter; comment]. Arthritis Rheum 1994;37(9):1413-4.
MacGregor AJ, Riste LK, Hazes JM, Silman AJ. Low prevalence of rheumatoid arthritis in black-Caribbeans compared with whites in inner city Manchester [see comments]. Ann Rheum Dis 1994;53(5):293-7.
Spector TD, Hochberg MC. Methodological problems in the epidemiological study of osteoarthritis. Ann Rheum Dis 1994;53(2):143-6.
Spector TD, Hart DJ, Doyle DV. Incidence and progression of osteoarthritis in women with unilateral knee disease in the general population: the effect of obesity. Ann Rheum Dis 1994;53(9):565-8. [PDF File]
Spotila LD, Colige A, Sereda L, Constantinou-Deltas CD, Whyte MP, Riggs BL, Shaker JL, Spector TD, Hume E, Olsen N. Mutation analysis of coding sequences for type I procollagen in individuals with low bone density. J Bone Miner Res 1994;9(6):923-32.
1993
Arden NK, Spector TD. Oestrogens, bones and systemic lupus erythematosus. Lupus 1993;2(6):381-2.
Spector TD, Hart DJ, Byrne J, Harris PA, Dacre JE, Doyle DV. Definition of osteoarthritis of the knee for epidemiological studies. Ann Rheum Dis. 1993;52(11):790-4.[PDF File]
Hall GM, Spector TD, Griffin AJ, Jawad AS, Hall ML, Doyle DV. The effect of rheumatoid arthritis and steroid therapy on bone density in postmenopausal women. Arthritis Rheum. 1993;36(11):1510-6. [PDF File]
Spector TD, Sambrook PN. Steroid osteoporosis. BMJ 1993;307(6903):519-20.
Masud T, Langley S, Wiltshire P, Doyle DV, Spector TD. Effect of spinal osteophytosis on bone mineral density measurements in vertebral osteoporosis. BMJ 1993;307(6897):172-3. [PDF File]
Spector TD, McCloskey EV, Doyle DV, Kanis JA. Prevalence of vertebral fracture in women and the relationship with bone density and symptoms: the Chingford study. J Bone Miner Res. 1993;8(7):817-22. [PDF File]
da Silva JA, Colville-Nash EV, Doyle DV, Kanis JA. Inflammation-induced cartilage degradation in female rodents. Protective role of sex hormones. Arthritis Rheum. 1993;36(7):1007-13. [PDF File]
Spector TD, James IT, Hall GM, Thompson PW, Perrett D, Hart DJ. Increased levels of urinary collagen crosslinks in females with rheumatoid arthritis. Clin Rheumatol. 1993;12(2):240-4.
McCloskey EV, Spector TD, Eyres KS, Fern ED, O'Rourke N, Vasikaran S, Kanis JA. The assessment of vertebral deformity: a method for use in population studies and clinical trials. Osteoporos. Int. 1993;3(3):138-47. [PDF File]
da Silva JA, Larbre JP, Spector TD, Perry LA, Scott DL, Willoughby DA. Protective effect of androgens against inflammation induced cartilage degradation in male rodents.Ann Rheum Dis. 1993;52(4):285-91. PDF File]
Spector TD, Hart DJ, Powell RJ. Prevalence of rheumatoid arthritis and rheumatoid factor in women: evidence for a secular decline. Ann. Rheum. Dis.1993;52(4):254-7. [PDF File]
Hall GM, Perry LA, Spector TD. Depressed levels of dehydroepiandrosterone sulphate in postemenopausal women with rheumatoid arthritis but no relation with axial bone density. Ann Rheum Dis 1993;52(3):211-4.
Spector TD. Epidemiology of the rheumatic diseases. Curr Opin Rheumatol 1993;5(2):132-7. [PDF File]
Spector TD, Hall GM, McCloskey EV, Kanis JA. Risk of vertebral fracture in women with rheumatoid arthritis. BMJ 1993;306(6877):558.
Hart DJ, Spector TD. The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. J Rheumatol. 1993;20(2):331-5.
Hart DJ, Spector TD. Cigarette smoking and risk of osteoarthritis in women in the general population: the Chingford study. Ann Rheum Dis. 1993;52(2):93-6. [PDF File]
MacGregor AJ, Fox H, Ollier WE, Snaith ML, Silman AJ. An identical twin pair discordant for rheumatoid arthritis and ankylosing spondylitis. Clin Exp Rheumatol 1993;11(4):425-8 .
MacGregor AJ, Silman AJ. Epidemiological approaches to the immunogenetics of autoimmune rheumatic disease. Ann Rheum Dis 1993;52(4):310-3.
Silman AJ, MacGregor AJ, Thomson W, Holligan S, Carthy D, Farhan A, Ollier WE. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br J Rheumatol 1993;32(10):903-7.
Spector TD, Hart DJ, Byrne J, Harris PA, Dacre JE, Doyle DV. Definition of osteoarthritis of the knee for epidemiological studies. Ann Rheum Dis 1993;52(11):790-4. [PDF File]
Worthington J, Rigby AS, MacGregor AJ, Silman AJ, Carthy D, Ollier WE. Lack of association of increased antibody levels to mycobacterial hsp65 with rheumatoid arthritis: results from a study of disease discordant twin pairs. Ann Rheum Dis 1993;52(7):542-4.
1992
Spector TD, Edwards AC, Thompson PW. Use of a risk factor and dietary calcium questionnaire in predicting bone density and subsequent bone loss at the menopause. Ann Rheum Dis 1992;51(11):1252-3.
Spector TD, Silman AJ. Sibship size does not increase the risk of developing rheumatoid arthritis. Br J Rheumatol 1992;31(11):763-6. [PDF File]
Thompson PW, Spector TD, James IT, Henderson E, Hart DJ. Urinary collagen crosslinks reflect the radiographic severity of knee osteoarthritis. Br J Rheumatol 1992;31(11):759-61.
Spector TD, Woodward L, Hall GM, Hammond A, Williams A, Butler MG, James IT, Hart DJ, Thompson PW, Scott DL. Keratan sulphate in rheumatoid arthritis, osteoarthritis and inflammatory diseases. Ann Rheum Dis 1992;51(10):1134-7. [PDF File]
Spector TD, Dacre JE, Harris PA, Huskisson EC. Radiological progression of osteoarthritis: an 11 year follow-up study of the knee. Ann Rheum Dis 1992;51(10):1107-10. [PDF File]
Spector TD, Hart DJ. How serious is knee osteoarthritis? Ann Rheum Dis. 1992;51(10):1105-6.
Da Silva JA, Spector TD. The role of pregnancy in the course and aetiology of rheumatoid arthritis. Clin Rheumatol 1992;11(2):189-94. [PDF File]
Hall GM, Spector TD, Studd JW. Carpal tunnel syndrome and hormone replacement therapy [letter]. BMJ 1992;304(6823):382.
MacGregor AJ, Silman AJ. A reappraisal of the measurement of disease occurrence in rheumatoid arthritis [editorial]. J Rheumatol 1992;19(8):1163-5.
MacGregor AJ, Dhillon VB, Binder A, Forte CA, Knight BC, Betteridge DJ, Isenberg DA. Fasting lipids and anticardiolipin antibodies as risk factors for vascular disease in systemic lupus erythematosus. Ann Rheum Dis 1992;51(2):152-5.
Spector TD, Hochberg MC. An epidemiological approach to the study of outcome in rheumatoid arthritis. Baillieres Clin Rheumatol 1992;6(1):235-46.
Spector TD, Brennan P, Harris PA, Studd JW, Silman AJ. Do current regimes of hormone replacement therapy protect against subsequent fractures? Osteoporos Int 1992;2(5):219-24. [PDF File]
Spector TD, Da Silva JA. Pregnancy and rheumatoid arthritis: an overview. Am J Reprod Immunol 1992;28(3-4):222-5. [PDF File]
1991
Chander CL, Spector TD. Oestrogens, joint disease, and cartilage. Ann Rheum Dis 1991;50(3):139-40 [PubMed].
Hart DJ, Spector TD, Brown P, Wilson P, Doyle DV, Silman AJ. Clinical signs of early osteoarthritis: reproducibility and relation to x ray changes in 541 women in the general population. Ann Rheum Dis 1991;50(7):467-70 [PubMed].
Scott DL, Spector TD. The case for preventive rheumatology [editorial]. Eur J Rheumatol Inflamm 1991;11(2):1-3 [PubMed].
Spector TD, Hart DJ, Brown P, Almeyda J, Dacre JE, Doyle DV, Silman AJ. Frequency of osteoarthritis in hysterectomized women. J Rheumatol 1991;18(12):1877-83 [PubMed].
Spector TD, Brennan P, Harris P, Studd JW, Silman AJ. Does estrogen replacement therapy protect against rheumatoid arthritis? J Rheumatol 1991;18(10):1473-6 [PubMed].
Spector TD, Thompson PW, Perry LA, McGarrigle HH, Edwards AC. The relationship between sex steroids and bone mineral content in women soon after the menopause. Clin Endocrinol (Oxf) 1991;34(1):37-41 [PubMed].
Spector TD, Hochberg MC. Comment on the article by Hernandez-Avila et al [letter; comment]. Arthritis Rheum 1991;34(3):373-4 [PubMed].
Spector TD. The epidemiology of rheumatic diseases. Curr Opin Rheumatol 1991;3(2):266-71 [PubMed].
Spector TD, Hart DJ, Huskisson EC. The use of radiographs in assessing the severity of knee osteoarthritis. J Rheumatol Suppl 1991;27:38-9 [PubMed].
Spector TD, Thompson SG. The potential and limitations of meta-analysis. J Epidemiol Community Health 1991;45(2):89-92 [PubMed].
Spector TD, Perry LA, Jubb RW. Endogenous sex steroid levels in women with generalised osteoarthritis. Clin Rheumatol 1991;10(3):316-9 [PubMed].
Thompson PW, Hart LE, Goldsmith CH, Spector TD, Bell MJ, Ramsden MF. Comparison of four articular indices for use in clinical trials in rheumatoid arthritis: patient, order and observer variation [see comments]. J Rheumatol 1991;18(5):661-5 [PubMed].
1990
Hazes JM, Silman AJ, Brand R, Spector TD, Walker DJ, Vandenbroucke JP. Influence of oral contraception on the occurrence of rheumatoid arthritis in female sibs. Scand J Rheumatol 1990;19(4):306-10 [PubMed].
Hochberg MC, Spector TD. Epidemiology of rheumatoid arthritis: update. Epidemiol Rev 1990;12:247-52 [PubMed].
Spector TD. Rheumatoid arthritis. Rheum Dis Clin North Am 1990;16(3):513-37 [PubMed].
Spector TD, Roman E, Silman AJ. The pill, parity, and rheumatoid arthritis. Arthritis Rheum 1990;33(6):782-9 [PubMed].
Spector TD, Silman AJ. Rheumatoid arthritis, diabetes, and schizophrenia [letter; comment]. Lancet 1990;335(8683):228-9 [PubMed].
Spector TD, Hochberg MC. The protective effect of the oral contraceptive pill on rheumatoid arthritis: an overview of the analytic epidemiological studies using meta-analysis. J Clin Epidemiol 1990;43(11):1221-30 [PubMed].
Spector TD, Silman AJ. Is poor pregnancy outcome a risk factor in rheumatoid arthritis? Ann Rheum Dis 1990;49(1):12-4 [PubMed].
Spector TD, Cooper C, Lewis AF. Trends in admissions for hip fracture in England and Wales, 1968-85. BMJ 1990;300(6733):1173-4 [PubMed].
Spector TD. The fat on the joint: osteoarthritis and obesity [editorial] [see comments]. J Rheumatol 1990;17(3):283-4 [PubMed].
1989
Hazes JM, Silman AJ, Brand R, Spector TD, Walker DJ, Vandenbroucke JP. A case-control study of oral contraceptive use in women with rheumatoid arthritis and their unaffected sisters. Br J Rheumatol 1989;28 Suppl 1:35- [PubMed].
Scott DL, Spector TD, Pullar T, McConkey B. What should we hope to achieve when treating rheumatoid arthritis? [see comments]. Ann Rheum Dis 1989;48(3):256-61 [PubMed].
Sharma P, Webb M, Levy J, Crombie J, Sadheura M, Stapleton C, Spector TD. Medical students and AIDS [letter]. Med Educ 1989;23(3):310 [PubMed].
Spector TD, Campion GD. Generalised osteoarthritis: a hormonally mediated disease. Ann Rheum Dis 1989;48(6):523-7 [PubMed].
Spector TD. Use of oestrogen replacement therapy in high risk groups in the United Kingdom. BMJ 1989;299(6713):1434-5 [PubMed].
Spector TD, Hochberg MC. The protective effect of the oral contraceptive pill on rheumatoid arthritis: an overview of the analytical epidemiological studies using meta-analysis. Br J Rheumatol 1989;28 Suppl 1:11-2 [PubMed].
Spector TD, Roman E, Silman AJ. A UK case-control study on the effect of parity and the oral contraceptive pill on the development of rheumatoid arthritis. Br J Rheumatol 1989;28 Suppl 1:32-5 [PubMed].
Spector TD, Huskisson EC. A rational approach to the prevention and treatment of postmenopausal osteoporosis. Drugs 1989;37(2):205-11 [PubMed].
Spector TD. Sex hormone measurements in rheumatoid arthritis. Br J Rheumatol 1989;28 Suppl 1:62-8 [PubMed].
Spector TD, Ollier W, Perry LA, Silman AJ, Thompson PW, Edwards A. Free and serum testosterone levels in 276 males: a comparative study of rheumatoid arthritis, ankylosing spondylitis and healthy controls. Clin Rheumatol 1989;8(1):37-41 [PubMed].
1988
Spector TD, Thompson PW, Evans SJ, Scott PL. Are slow-acting antirheumatic drugs being given earlier in rheumatoid arthritis? [letter]. Br J Rheumatol 1988;27(6):498-9 [PubMed].
Spector TD, Scott DL. What happens to patients with rheumatoid arthritis? The long-term outcome of treatment. Clin Rheumatol 1988;7(3):315-30 [PubMed].
Spector TD, Brown GC, Silman AJ. Increased rates of previous hysterectomy and gynaecological operations in women with osteoarthritis. BMJ 1988;297(6653):899-900 [PubMed].
Spector TD, Blake DR. Effect of cigarette smoking on Langerhans' cells [letter]. Lancet 1988;2(8618):1028 [PubMed].
Spector TD, Silman AJ. Parental mortality and rheumatoid arthritis [letter]. J Rheumatol 1988;15(1):150-1 [PubMed].
Spector TD, Ollier WE, Perry LA, Silman AJ. Evidence for similarity in testosterone levels in haplotype identical brothers. Dis Markers 1988;6(2):119-2 [PubMed].
Spector TD, Perry LA, Tubb G, Silman AJ, Huskisson EC. Low free testosterone levels in rheumatoid arthritis. Ann Rheum Dis 1988;47(1):65-8 [PubMed].
Spector TD. Epidemiological aspects of studying outcome in rheumatoid arthritis. Br J Rheumatol 1988;27 Suppl 1:5-11 [PubMed].
1987
Spector TD, Silman AJ. Oral contraceptives and rheumatoid arthritis. Bias in observational studies of cause-effect relationships [letter]. J Chronic Dis 1987;40(11):1063-7 [PubMed].
Spector TD, Silman AJ. Does the negative association between rheumatoid arthritis and schizophrenia provide clues to the aetiology of rheumatoid arthritis? Br J Rheumatol 1987;26(4):307-10 [PubMed].
Spector TD, Perry LA, Tubb G, Huskisson EC. Androgen status of females with RA [letter]. Br J Rheumatol 1987;26(4):316-8 [PubMed]
Spector TD. Osteoporosis - NICE sets new challenges for London. Capital Doctor 2004 Sept, 36:22.