Our goal is to understand how genetic variations relate to human health and disease. We have collected genetic information on over 6,000 twins (both MZ and DZ) using both state of the art genotyping (Illumina platform) and sequencing (whole genome sequencing) techniques.
In the last 5 years we lead/collaborated with the major international teams to identify genes causing the most common (and sometimes lethal) diseases (cardiovascular, diabetes, obesity, fractures, and osteoarthritis just to mention the most common).
With the advent of the new sequencing method, we were able to analyse every single variant on the individual genome in more than 2,000 samples as part of UK10K project. This information will be freely available to the whole scientific community as soon as the project terminates at the end of this year.